Disease relevance of Radioisotope Renography

• These results indicate that furosemide-induced volume depletion may increase the diagnostic sensitivity of captopril-enhanced 99mTc-DTPA renography in the detection of unilateral renovascular hypertension [1].
• We conclude that simplified captopril renography is highly sensitive and specific in the diagnosis of renal artery stenosis in a clinically selected high-risk population and that the test accurately predicts the success or failure of therapeutic intervention [2].
• Simplified captopril renography was 91% sensitive and 94% specific in identifying or excluding renal artery stenosis in the combined group, with no difference in the diagnostic utility between groups 1 and 2, or in those with renal insufficiency (n = 38) or those with bilateral disease (n = 17) [2].
• [131I] Hippuran renography in the detection of orthostatic hypertension [3].
• Captopril-stimulated renography is widely used to screen selected groups of hypertensive patients for renal vascular disease [4].

High impact information on Radioisotope Renography

• We used captopril renography to screen for renovascular disease [5].
• This study assesses the predictive diagnostic value of furosemide-131I-hippuran renography after angiotensin-converting enzyme (ACE) inhibition in patients with and without RVH [6].
• Eleven patients with renovascular hypertension were followed prospectively with estimation of renal function by 99mTc-diethylenetriaminepentaacetic acid (DTPA) clearance (determined by computer analysis of scintillation camera renography) [7].
• Excretory profiles were assessed by furosemide-stimulated diethylenetriaminepentaacetic acid renography [8].
• The renographic evaluation was first performed after ingestion of the daily therapy of angiotensin II receptor antagonist alone (Sartan renography) and was repeated within 7 d after the acute addition of 25 mg of captopril to chronic treatment with angiotensin II receptor antagonist (captopril-Sartan renography) [9].

Chemical compound and disease context of Radioisotope Renography

• Currently, no data exist regarding the reliability of captopril renography in patients with renovascular hypertension evaluated while they are under chronic treatment with angiotensin II (AT1) receptor antagonists (Sartans) [9].
• Iodine-123 hippurate renography was at least as useful as [99mTc]DTPA renography in this respect, while [99mTc]DMSA scintigraphy can be used particularly in segmental stenosis [10].
• MR renography was performed with a T1-weighted approach by using three-dimensional fast imaging with steady-state precession, or FISP, sequences after administration of a bolus of 0.1 mmol of gadopentetate dimeglumine per kilogram of body weight [11].
• Enalaprilat-enhanced renography in a rat model of renovascular hypertension [12].
• Steady-state captopril renography (SSCR) is an original technique for assessing the captopril-induced increase in technetium-99m mercaptoacetyltriglycine (99mTc-MAG3) mean parenchymal transit time (MPTT) in kidneys affected with functional renal artery stenosis (RAS) [13].

Biological context of Radioisotope Renography

• Considering that aspirin, compared with captopril, reduces renal blood flow and, thus, tubular tracer delivery in poststenotic kidneys, aspirin renography is expected to be more useful, particularly if tubular tracers are used [14].
• Interpretation of captopril renography by nuclear medicine physicians [15].
• These medications should be stopped before captopril renography, and physicians should be aware of this possible drug interaction if bilateral symmetrical renal function deterioration is seen on a patient's captopril renogram [16].
• Radionuclide captopril renography in postpartum renal artery aneurysms [17].
• At ages 4, 12 and 24 weeks single kidney function was assessed using 99mtechnetium diethylenetriaminepentaacetic acid differential uptake on renography combined with the glomerular filtration rate estimated from the plasma clearance of 99mtechnetium diethylenetriaminepentaacetic acid [18].

Anatomical context of Radioisotope Renography

• After this, digital subtraction angiography with renal vein renins or captopril renography are appropriate steps [19].
• Extravascular chest wall technetium 99m diethylene triamine penta-acetic acid: implications for the measurement of renal function during renography [20].
• Renal, ureteral, and vesicle functions were evaluated in 209 patients with obstructive lesions of the ureter due to schistosomiasis haematobia (bilharziasis), using Hippuran I131 extended renography [21].
• Our results suggest that diuresis renography gives no conclusive information about the upper urinary tract in kidneys with a 51Cr-EDTA clearance below 25 ml/min x 1.73 m2, even when the dose of frusemide is increased to 7.5 mg/kg [22].
• Application of radioisotope renography with technetium-99m mercaptoacetyltriglycine on patients with spinal cord injuries [23].

Associations of Radioisotope Renography with chemical compounds

• After the initial urogram, sequential DTPA scanning and renography are sufficient for follow-up [24].
• The study also demonstrated that furosemide will significantly and predictably influence renography and the pertechnetate study [25].
• I-125 Hippuran renography was performed before clamping, immediately after clamp release, and at 2, 4, 6, and 14 days later [26].
• Interrupting the vasoactive action of angiotensin II alone on the efferent glomerular arteries, which can also be selectively achieved by chronic administration of angiotensin II receptor antagonists, does not fully explain the effectiveness of captopril renography in detecting renovascular hypertensive patients [9].
• Subgroup analysis of modest (50-75%) and severe (> or =75%) RAS, or of plasma creatinine greater than 120 micromol/L, also showed no difference between captopril and aspirin renography [14].

Gene context of Radioisotope Renography

• Procedure guideline for diuretic renography in children. Society of Nuclear Medicine [27].
• Reliability of captopril renography in patients under chronic therapy with angiotensin II (AT1) receptor antagonists [9].
• With further experience, renography may become a useful tool for predicting postoperative outcome in ischemic CM [28].
• 99mTc-DTPA renography and plasma renin activity measurements were performed before and after an oral dose of 50 mg captopril [29].
• Patients were excluded from review when they had bilateral ureteropelvic junction obstruction, a solitary kidney, associated vesicoureteral reflux, or other bladder or ureteral abnormalities, and when preoperative and postoperative renography studies were not available [30].

Analytical, diagnostic and therapeutic context of Radioisotope Renography

• I-131 Hippuran renography of functioning grafts was carried out 397 times, and the Tc-99m sequential scintigraphy 379 times [25].
• Group III contained 10 patients after successful percutaneous transluminal renal angioplasty (PTRA) with negative captopril renography results [31].
• RESULTS: Findings from serial follow-up CT and laboratory analysis performed in all patients and captopril renography performed in five of the patients who underwent juxtarenal stent-graft placement did not reveal impaired renal function or perfusion [32].
• The relative value of captopril renography and arteriography is similar [33].
• CONCLUSION: In this preliminary experience in an animal model, captopril MR renography provided data consistent with expectations based on conventional renographic results [11].

References