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Gene Review

COX1  -  cytochrome c oxidase subunit I

Ovis aries

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Psychiatry related information on COX1

  • The assay can be used to assess the relative selectivity of plant-derived inhibitors on COX-1 and COX-2 Assay conditions were optimized for both enzymes with respect to concentration of cofactors (l-epinephrine, reduced glutathione, and hematin), activation time (enzyme and cofactors), reaction time, and pH [1].

High impact information on COX1


Biological context of COX1


Anatomical context of COX1

  • 2. Using fluorescence microscopy and immunogold staining, COX1 appeared more abundant than COX2 in endothelial and smooth muscle cells, and this difference was greater before-term [4].
  • Inside muscle cells, COX1 and COX2 immunoreactivity was located primarily in the perinuclear region [4].
  • We conclude that the pregnancy-induced increases in prostacyclin production by uterine arteries is largely due to a dramatic increase in expression of COX-1 mRNA and associated protein predominantly occurring in the uterine artery endothelium and, to a lesser extent, in the VSM [6].
  • Further studies with the cultured cell model will enable determination of the factors that directly regulate COX-1 expression in the developing pulmonary vasculature [5].
  • Endothelial and vascular smooth muscle (VSM) COX-1 protein levels and uterine artery endothelial cell COX-1 mRNA levels were compared [7].

Associations of COX1 with chemical compounds

  • The present study was performed to test the relative roles of prostaglandin endoperoxide synthases-1 and -2 (PGHS-1 and 2, or COX-1 and 2) as potential mediators of this interaction [8].
  • METHODS: Chronically catheterized and instrumented fetal sheep were subjected to transient brachiocephalic occlusion (BCO) after intracerebroventricular injection of resveratrol (PGHS-1 or COX-1 inhibitor), nimesulide (PGHS-2 or COX-2 inhibitor), or vehicle [8].
  • 3. The COX2 inhibitor L-745,337 (1--10 microM) contracted the isolated ductus at term, the response being almost as high as that to indomethacin (dual COX1/COX2 inhibitor) over the same dose-range [4].
  • Exposure to estradiol-17beta (E2beta, 10(-)10 to 10(-)6 M) caused a dose-related increase in COX-1 mRNA expression that was evident after 48 h and maximal at 10(-)8 M (fourfold increase) [2].
  • Endothelial vasodilator production by uterine and systemic arteries. VIII. Estrogen and progesterone effects on cPLA2, COX-1, and PGIS protein expression [9].

Regulatory relationships of COX1

  • NOC7 activated the COX-1 activity but inhibited the COX-2 activity at concentrations ranging from 1 to 50 microM [10].

Other interactions of COX1

  • Aspirin revealed a similar COX-1 deleterious action, since only when both COX-1 and COX-2 were inhibited, LP was put in evidence adding functional improvement over that obtained in NP hearts treated with aspirin [11].

Analytical, diagnostic and therapeutic context of COX1


  1. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. Noreen, Y., Ringbom, T., Perera, P., Danielson, H., Bohlin, L. J. Nat. Prod. (1998) [Pubmed]
  2. Estrogen upregulates cyclooxygenase-1 gene expression in ovine fetal pulmonary artery endothelium. Jun, S.S., Chen, Z., Pace, M.C., Shaul, P.W. J. Clin. Invest. (1998) [Pubmed]
  3. Chemical and structural diversity in cyclooxygenase protein active sites. Huff, R.G., Bayram, E., Tan, H., Knutson, S.T., Knaggs, M.H., Richon, A.B., Santago, P., Fetrow, J.S. Chem. Biodivers. (2005) [Pubmed]
  4. Function of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the ductus arteriosus from foetal lamb: differential development and change by oxygen and endotoxin. Coceani, F., Ackerley, C., Seidlitz, E., Kelsey, L. Br. J. Pharmacol. (2001) [Pubmed]
  5. Developmental changes in prostacyclin synthesis are conserved in cultured pulmonary endothelium and vascular smooth muscle. Shaul, P.W., Pace, M.C., Chen, Z., Brannon, T.S. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  6. Pregnancy increases ovine uterine artery endothelial cyclooxygenase-1 expression. Janowiak, M.A., Magness, R.R., Habermehl, D.A., Bird, I.M. Endocrinology (1998) [Pubmed]
  7. Endothelial vasodilator production by uterine and systemic arteries. IV. Cyclooxygenase isoform expression during the ovarian cycle and pregnancy in sheep. Habermehl, D.A., Janowiak, M.A., Vagnoni, K.E., Bird, I.M., Magness, R.R. Biol. Reprod. (2000) [Pubmed]
  8. Differential modulation of ovine fetal ACTH secretion by PGHS-1 and PGHS-2. Reimsnider, S., Wood, C.E. Neuroendocrinology (2006) [Pubmed]
  9. Endothelial vasodilator production by uterine and systemic arteries. VIII. Estrogen and progesterone effects on cPLA2, COX-1, and PGIS protein expression. Rupnow, H.L., Phernetton, T.M., Modrick, M.L., Wiltbank, M.C., Bird, I.M., Magness, R.R. Biol. Reprod. (2002) [Pubmed]
  10. Effects of reactive oxygen and nitrogen species on cyclooxygenase-1 and -2 activities. Fujimoto, Y., Uno, E., Sakuma, S. Prostaglandins Leukot. Essent. Fatty Acids (2004) [Pubmed]
  11. Role of the cyclooxygenase pathway in the protection against postischemic stunning in conscious sheep. Lascano, E.C., Del Valle, H.F., Negroni, J.A. Mol. Cell. Biochem. (2006) [Pubmed]
  12. The role of nitric oxide and prostaglandin signaling pathways in spinal nociceptive processing in chronic inflammation. Dolan, S., Field, L.C., Nolan, A.M. Pain (2000) [Pubmed]
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