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PLDALPHA1  -  phospholipase D alpha 1

Arabidopsis thaliana

Synonyms: PHOSPHOLIPASE D, PLD
 
 
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Disease relevance of PLDALPHA1

 

High impact information on PLDALPHA1

 

Biological context of PLDALPHA1

 

Anatomical context of PLDALPHA1

 

Associations of PLDALPHA1 with chemical compounds

 

Other interactions of PLDALPHA1

  • These results indicate that PA produced by PLD alpha 1 inhibits the function of the negative regulator ABI1, thus promoting ABA signaling [7].
 

Analytical, diagnostic and therapeutic context of PLDALPHA1

  • Anti-PLDalpha plants recovered fully following rehydration after 10 d of stress. qRT-PCR revealed up to 18-fold lower values for PLDalpha transcripts in stressed anti-PLDalpha plants when compared with stressed Col-0 [1].
  • In contrast, isothermal titration calorimetry data of PLDalpha C2 were consistent with 1-3 low affinity Ca(2+)-binding sites with K(d) in the range of 590-470 micrometer [9].
  • Sequence analysis reveals that PLDbeta is evolutionarily divergent from PLDalpha and that its N terminus contains a regulatory Ca2+-dependent phospholipid-binding (C2) domain that is found in a number of signal transducing and membrane trafficking proteins [10].

References

  1. Early PLD{alpha}-mediated events in response to progressive drought stress in Arabidopsis: a transcriptome analysis. Mane, S.P., Vasquez-Robinet, C., Sioson, A.A., Heath, L.S., Grene, R. J. Exp. Bot. (2007) [Pubmed]
  2. A novel phospholipase D of Arabidopsis that is activated by oleic acid and associated with the plasma membrane. Wang, C., Wang, X. Plant Physiol. (2001) [Pubmed]
  3. The oleate-stimulated phospholipase D, PLDdelta, and phosphatidic acid decrease H2O2-induced cell death in Arabidopsis. Zhang, W., Wang, C., Qin, C., Wood, T., Olafsdottir, G., Welti, R., Wang, X. Plant Cell (2003) [Pubmed]
  4. Antisense suppression of phospholipase D alpha retards abscisic acid- and ethylene-promoted senescence of postharvest Arabidopsis leaves. Fan, L., Zheng, S., Wang, X. Plant Cell (1997) [Pubmed]
  5. Molecular heterogeneity of phospholipase D (PLD). Cloning of PLDgamma and regulation of plant PLDgamma, -beta, and -alpha by polyphosphoinositides and calcium. Qin, W., Pappan, K., Wang, X. J. Biol. Chem. (1997) [Pubmed]
  6. Rice phospholipase D isoforms show differential cellular location and gene induction. McGee, J.D., Roe, J.L., Sweat, T.A., Wang, X., Guikema, J.A., Leach, J.E. Plant Cell Physiol. (2003) [Pubmed]
  7. Phospholipase D alpha 1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling. Zhang, W., Qin, C., Zhao, J., Wang, X. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. Subcellular distribution and tissue expression of phospholipase Dalpha, Dbeta, and Dgamma in Arabidopsis. Fan, L., Zheng, S., Cui, D., Wang, X. Plant Physiol. (1999) [Pubmed]
  9. Distinct Ca2+ binding properties of novel C2 domains of plant phospholipase dalpha and beta. Zheng, L., Krishnamoorthi, R., Zolkiewski, M., Wang, X. J. Biol. Chem. (2000) [Pubmed]
  10. Molecular cloning and functional analysis of polyphosphoinositide-dependent phospholipase D, PLDbeta, from Arabidopsis. Pappan, K., Qin, W., Dyer, J.H., Zheng, L., Wang, X. J. Biol. Chem. (1997) [Pubmed]
 
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