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Gene Review

ARID1A  -  AT rich interactive domain 1A (SWI-like)

Homo sapiens

Synonyms: ARID domain-containing protein 1A, AT-rich interactive domain-containing protein 1A, B120, BAF250, BAF250A, ...
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Disease relevance of ARID1A


High impact information on ARID1A


Biological context of ARID1A

  • B120 appeared to be encoded by 17 exons in more than 20-kbp genomic DNA [2].
  • The Osa1 gene was localized to mouse chromosome 4, within the region syntenic to chromosomal position 1p35-p36 of its human counterpart [6].
  • These findings suggested that B120 gene expression is associated with lipid metabolism, and that overexpression of B120 may result in lipid deposition in various cells, including those of fibroblastic cell lines [7].
  • Hydrophilicity plot analysis of the deduced amino acid sequence of the recombinant protein predicted the hexapeptide sequence DREGRD as the antigenic determinant of P270 [8].
  • Iron modulates phenotypic variation and phosphorylation of P270 in double-stranded RNA virus-infected Trichomonas vaginalis [3].

Anatomical context of ARID1A

  • The other neuroblastomas expressed B120 gene product in the nucleus; however, the intensity of staining was much weaker and equivalent to that in developing human brain stem cells in the subventricular region [2].
  • RNase protection analysis indicates a widespread expression of the Osa1 gene during mouse development, in adult tissues, and in cultured cell lines [6].
  • Schnyder crystalline corneal dystrophy is thought to be a primary abnormality of corneal lipid metabolism, resulting in opacification secondary to lipid accumulation.In order to examine the function of B120, we introduced B120 cDNA with an expression vector into various cell lines including Cos1, C3H/10T1/2 and NIH/3T3 cells [7].

Associations of ARID1A with chemical compounds

  • This difference could all be accounted for by increased accident rate in OSA patients with the highest AHI (OSA3) (MVA/yr: 0.11+/-0.15, 0.08+/-0.12, 0.06+/-0.14 for OSA groups 3,2,1 respectively) as there was no differences among Control, OSA1 and OSA2 accident rates [9].
  • The ED50S of E-4695 and ciprofloxacin were 33.0 and 145.5 mg/kg against P. aeruginosa HS-116 and 9.6 and 18.9 mg/kg against P. aeruginosa B-120, respectively [10].

Physical interactions of ARID1A


Other interactions of ARID1A

  • Here we report the isolation of two related but distinct cDNA clones, hOsa1 and hOsa2, that encode the largest subunits of human SWI/SNF. hOsa1 is identical to previously reported BAF250, and hOsa2 shares a high degree of sequence similarity with hOsa1 [11].
  • We previously reported a novel human cDNA, designated B120, containing a CAG repeat length polymorphism and many repeat units, loosely identified as YXQQP which is found in several human RNA binding proteins [7].
  • Since the cornea is composed of fibroblastic cells, overfunction of B120 could be related to the pathogenesis of Schnyder crystalline corneal dystrophy [7].
  • Skeletrophin is an actin-binding cytoskeleton-related molecule, which is induced by the overexpression of truncated human SWI1 (SMARCF1) [12].

Analytical, diagnostic and therapeutic context of ARID1A

  • A novel human cDNA containing CAG repeats, designated B120, was cloned by PCR amplification [13].
  • In the present study, the B120 gene was mapped to human chromosome 1p35-36.1 by fluorescence in situ hybridization (FISH) [7].
  • Examination of batch cultures by flow cytofluorometry with monoclonal antibody (MAb) to P270 yields both fluorescent and nonfluorescent trichomonads [3].
  • Some strains within a cluster showed identical ribotype patterns with both endonucleases (A. naeslundii B120 and A. naeslundii B102 from cluster 3), while others showed the same pattern with BamHI but a different pattern with PvuII (A. naeslundii ATCC 12104 and 398A from cluster 5) [14].
  • After a period of restricted diet, the selected 16 children were recalled; 12 AD-free children (8 males and 14 females, aged 12 months-4.33 years (mean age 2.21 +/- 1.05 years) were evaluated by SPT and radioallergosorbent test (RAST) for the following allergens: bovine meat, ovine meat, BSA 1 mg/ml, OSA 1 mg/ml [15].


  1. Monoclonal antibodies to human osteosarcoma-associated antigen(s). Tsang, K.Y., Warren, R.Q., Bishop, L., Pathak, S., Koger, B., LaVia, M.F. J. Natl. Cancer Inst. (1986) [Pubmed]
  2. Expression of SMARCF1, a truncated form of SWI1, in neuroblastoma. Takeuchi, T., Nicole, S., Misaki, A., Furihata, M., Iwata, J., Sonobe, H., Ohtsuki, Y. Am. J. Pathol. (2001) [Pubmed]
  3. Iron modulates phenotypic variation and phosphorylation of P270 in double-stranded RNA virus-infected Trichomonas vaginalis. Alderete, J.F. Infect. Immun. (1999) [Pubmed]
  4. Induction of immunity to a human osteosarcoma-associated antigen in mice using anti-idiotypic antibodies. Warren, R.Q., Tsang, K.Y. Clin. Immunol. Immunopathol. (1990) [Pubmed]
  5. A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex. Nie, Z., Xue, Y., Yang, D., Zhou, S., Deroo, B.J., Archer, T.K., Wang, W. Mol. Cell. Biol. (2000) [Pubmed]
  6. Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex. Kozmik, Z., Machon, O., Králová, J., Kreslová, J., Paces, J., Vlcek, C. Genomics (2001) [Pubmed]
  7. Chromosomal mapping and expression of the human B120 gene. Takeuchi, T., Furihata, M., Heng, H.H., Sonobe, H., Ohtsuki, Y. Gene (1998) [Pubmed]
  8. The phenotypically variable surface protein of Trichomonas vaginalis has a single, tandemly repeated immunodominant epitope. Dailey, D.C., Alderete, J.F. Infect. Immun. (1991) [Pubmed]
  9. Sleep apnea & automobile crashes. George, C.F., Smiley, A. Sleep. (1999) [Pubmed]
  10. E-4695, a new C-7 azetidinyl fluoronaphthyridine with enhanced activity against gram-positive and anaerobic pathogens. Guinea, J., Gargallo-Viola, D., Robert, M., Tudela, E., Xicota, M.A., Garcia, J., Esteve, M., Coll, R., Pares, M., Roser, R. Antimicrob. Agents Chemother. (1995) [Pubmed]
  11. Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors. Inoue, H., Furukawa, T., Giannakopoulos, S., Zhou, S., King, D.S., Tanese, N. J. Biol. Chem. (2002) [Pubmed]
  12. Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma. Takeuchi, T., Adachi, Y., Ohtsuki, Y. DNA Cell Biol. (2005) [Pubmed]
  13. Molecular cloning and expression of a novel human cDNA containing CAG repeats. Takeuchi, T., Chen, B.K., Qiu, Y., Sonobe, H., Ohtsuki, Y. Gene (1997) [Pubmed]
  14. Characterization of Actinomyces with genomic DNA fingerprints and rRNA gene probes. Bowden, G., Johnson, J., Schachtele, C. J. Dent. Res. (1993) [Pubmed]
  15. Meat allergy: I--Specific IgE to BSA and OSA in atopic, beef sensitive children. Fiocchi, A., Restani, P., Riva, E., Qualizza, R., Bruni, P., Restelli, A.R., Galli, C.L. Journal of the American College of Nutrition. (1995) [Pubmed]
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