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Gene Review:

FCRL5 - Fc receptor-like 5

Homo sapiens

Synonyms: BXMAS1, CD307, CD307e, FCRH5, Fc receptor homolog 5, ...

Hatzivassiliou, G. et al., Ise, T. et al., Ise, T. et al., Inoue, J. et al., Miller, I. et al., et al.

Nakayama, Weissman, Bothwell,

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Disease relevance of FCRL5

CONCLUSIONS: Our results provide the first evidence that IRTA2 is expressed on the surface of human lymphoma cell lines and HCL cells [1].
In a FACS analysis, MAbs F56 and F119 detected IRTA2 expression in six of seven B cell non-Hodgkin's lymphoma and one of six Burkitt's lymphoma cell lines [1].
Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma [2].

High impact information on FCRL5

Both genes are selectively expressed in mature B cells: IRTA1 in marginal zone B cells and IRTA2 in centrocytes, marginal zone B cells, and immunoblasts [3].
By cloning the breakpoints of a (1;14) (q21;q32) chromosomal translocation in a myeloma cell line, we have identified two novel genes, IRTA1 and IRTA2, encoding cell surface receptors homologous to the Fc and inhibitory receptor families [3].
IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy [3].
In tumor cell lines with 1q21 abnormalities, IRTA2 expression is deregulated [3].
A corresponding transcriptional mapping using oligonucleotide arrays extracted three up-regulated genes (IRTA2, PDZK1, and S100A6) within the smallest region of overlapping in amplifications [4].

Biological context of FCRL5

The IRTA1 and IRTA2 genes encode immunoglobulinlike cell surface receptors expressed in B cells and involved in chromosome 1q21 translocations in B-cell malignancy [5].
Because of the restricted expression of mRNA in B cell-lineage cells, IRTA2 is a new potential target for the immunotherapy of B cell malignancies [1].
EXPERIMENTAL DESIGN: A mouse used for cell fusion was DNA-immunized with an expression plasmid encoding the IRTA2 cDNA [1].
A search of the human genome revealed 5 additional closely linked homologous genes many of which contain BXMAS1 domains as well [6].

Anatomical context of FCRL5

Soluble CD307 levels correlated with plasma cell percentages in bone marrow aspirates in MM and total white blood cells in CLL [2].
CD307 on the cell membrane was detected by flow cytometry in 8/8 MM, 23/29 CLL and 4/5 MCL samples [2].

Other interactions of FCRL5

Three of these new CDs, CD267, CD269, and CD307 presented a B cell-restricted expression pattern [7].

Analytical, diagnostic and therapeutic context of FCRL5

IRTA2 could be useful as a new target for immunotherapy [1].
One soluble and two membrane-bound forms have been predicted and an enzyme-linked immunosorbent assay (ELISA) for soluble CD307 established [2].
This study aimed to develop immunoassays for soluble IRTA2/FcRH5 proteins in human serum [8].

References

Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies. Ise, T., Maeda, H., Santora, K., Xiang, L., Kreitman, R.J., Pastan, I., Nagata, S. Clin. Cancer Res. (2005) [Pubmed]
Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma. Ise, T., Nagata, S., Kreitman, R.J., Wilson, W.H., Wayne, A.S., Stetler-Stevenson, M., Bishop, M.R., Scheinberg, D.A., Rassenti, L., Kipps, T.J., Kyle, R.A., Jelinek, D.F., Pastan, I. Leukemia (2007) [Pubmed]
IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. Hatzivassiliou, G., Miller, I., Takizawa, J., Palanisamy, N., Rao, P.H., Iida, S., Tagawa, S., Taniwaki, M., Russo, J., Neri, A., Cattoretti, G., Clynes, R., Mendelsohn, C., Chaganti, R.S., Dalla-Favera, R. Immunity (2001) [Pubmed]
Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma. Inoue, J., Otsuki, T., Hirasawa, A., Imoto, I., Matsuo, Y., Shimizu, S., Taniwaki, M., Inazawa, J. Am. J. Pathol. (2004) [Pubmed]
IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. Miller, I., Hatzivassiliou, G., Cattoretti, G., Mendelsohn, C., Dalla-Favera, R. Blood (2002) [Pubmed]
BXMAS1 identifies a cluster of homologous genes differentially expressed in B cells. Nakayama, Y., Weissman, S.M., Bothwell, A.L. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry. Vidal-Laliena, M., Romero, X., March, S., Requena, V., Petriz, J., Engel, P. Cell. Immunol. (2005) [Pubmed]
Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera. Ise, T., Kreitman, R.J., Pastan, I., Nagata, S. Clin. Chem. Lab. Med. (2006) [Pubmed]

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