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Gene Review

TNFRSF17  -  tumor necrosis factor receptor superfamily...

Homo sapiens

Synonyms: B-cell maturation protein, BCM, BCMA, CD269, TNFRSF13A, ...
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Disease relevance of TNFRSF17


Psychiatry related information on TNFRSF17

  • BACKGROUND: Body cell mass (BCM) may be estimated in clinical practice to assess functional nutritional status, eg, in patients with anorexia nervosa [6].
  • The average time spent weekly doing physical activity resulted in T1DM group directly correlated to BCM (P < 0.001) and inversely correlated with BMDspine (P < 0.05) and L2L4BMDvol (P < 0.01) [7].
  • The objectives of this observational study were as follows: 1) to compare minimal observable energy expenditure (MOEE) between 2 subgroups of breast-fed infants, a BM group in which breast milk was the only source of milk and a BCM group given cow's milk in addition to breast milk; and 2) to identify potential mediators of a feeding pattern effect [8].

High impact information on TNFRSF17

  • Thus, the precursor cells that monoclonally expand to produce a lymphoid crisis are capable of immunoglobulin-gene rearrangements and represent discrete steps in early B-cell maturation [9].
  • Here we determine the crystal structures of sTALL-1 complexed with the extracellular domains of BCMA and BAFF-R at 2.6 and 2.5 A, respectively [10].
  • Depletion of circulating immunoglobulins or of individual Fc-gamma receptors had no effect on scrapie pathogenesis if B-cell maturation was unaffected [11].
  • In vivo, ICOS is highly expressed on tonsillar T cells, which are closely associated with B cells in the apical light zone of germinal centres, the site of terminal B-cell maturation [12].
  • Signalling by membrane immunoglobulin, the B-lymphocyte antigen receptor, regulates B-cell maturation and activation [13].

Chemical compound and disease context of TNFRSF17

  • PURPOSE: To compare the sensitivity and specificity of an automated microparticle enzyme immunoassay (MEIA) for breast cancer mucin (IMx BCM; Abbott Laboratories, North Chicago, IL) to that of CA15-3 and carcinoembryonic antigen (CEA) for detecting and monitoring breast cancer [14].
  • Comparison of these results with published data for young adults indicates that obligatory urinary N losses in elderly women are similar to those for young women when expressed per unit body weight but higher than young women and men when expressed per unit creatinine excretion and per unit BCM [15].
  • Dronabinol and megestrol acetate may promote weight gain; however, dronabinol may have adverse effects, and most of the gain with megestrol acetate is in fat rather than BCM [16].
  • AIMS: To verify whether fluorouracil (FU) clearance (CL) and volume of distribution (V(ss)) are better correlated with specific body compartments, such as body cell mass (BCM), total body water (TBW) or fat free mass (FFM), rather than with body surface area (BSA) or total body weight (BW) [17].
  • We used a sensitive whole body counter which measures potassium-40 (40K) to determine total body potassium and to estimate body cell mass (BCM) in 104 previously untreated patients with upper gastrointestinal malignancies, 233 normal volunteers, and 18 patients with anorexia nervosa [18].

Biological context of TNFRSF17


Anatomical context of TNFRSF17

  • Thus, APRIL-TALL-I and BCMA-TACI form a two ligands-two receptors pathway involved in stimulation of B and T cell function [19].
  • Previously, we reported in a human malignant myeloma cell line that BCMA is not primarily present on the cell surface but lies in a perinuclear structure that partially overlaps the Golgi apparatus [23].
  • BAFF-R expression increased initially and then decreased with a corresponding induction of TACI and BCMA expression during differentiation to plasma cells (PCs) [24].
  • However, GCs in B cell maturation Ag-Fc-treated mice dissipated more rapidly than those of control mice and did not form a mature follicular dendritic cell reticulum [25].
  • Unlike their putative germinal center B-cell precursors, HRS cells lacked BAFF-R, but expressed TACI and BCMA, a phenotype similar to that of plasmacytoid B cells [26].

Associations of TNFRSF17 with chemical compounds

  • Second, shotgun alanine scanning of BCMA was used to map critical residues for either APRIL or BAFF binding [21].
  • The single cysteine-rich domain of BCMA and BAFF-R both have saddle-like architectures, which sit on the horseback-like surface formed by four coil regions on each individual sTALL-1 monomer [10].
  • In agreement, mutation of three lysines in a putative heparin sulfate-binding motif, which is not part of the TNF fold, destroys interaction with HSPG, while binding to BCMA is unaffected [27].
  • Regulation of B cell maturation and differentiation. I. Suppression of pokeweed mitogen-induced B cell differentiation by tumor necrosis factor (TNF) [28].
  • Moreover, PGE2(+) T lymphocytes did exert a strong suppressor activity on mitogen- or allogeneic cell-induced lymphocyte proliferation as well as on pokeweed mitogen-driven B cell maturation into Ig-containing cells [29].

Physical interactions of TNFRSF17


Regulatory relationships of TNFRSF17


Other interactions of TNFRSF17


Analytical, diagnostic and therapeutic context of TNFRSF17


  1. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Gross, J.A., Johnston, J., Mudri, S., Enselman, R., Dillon, S.R., Madden, K., Xu, W., Parrish-Novak, J., Foster, D., Lofton-Day, C., Moore, M., Littau, A., Grossman, A., Haugen, H., Foley, K., Blumberg, H., Harrison, K., Kindsvogel, W., Clegg, C.H. Nature (2000) [Pubmed]
  2. A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma. Laâbi, Y., Gras, M.P., Carbonnel, F., Brouet, J.C., Berger, R., Larsen, C.J., Tsapis, A. EMBO J. (1992) [Pubmed]
  3. Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment. Tai, Y.T., Li, X.F., Breitkreutz, I., Song, W., Neri, P., Catley, L., Podar, K., Hideshima, T., Chauhan, D., Raje, N., Schlossman, R., Richardson, P., Munshi, N.C., Anderson, K.C. Cancer Res. (2006) [Pubmed]
  4. B cell maturation in chronic lymphocytic leukemia. III. Effect of recombinant cytokines on leukemic B cell proliferation. Nerl, C., Janssen, O., Kabelitz, D. Leukemia (1988) [Pubmed]
  5. Cytokines and the pathogenesis of myasthenia gravis. Zhang, G.X., Navikas, V., Link, H. Muscle Nerve (1997) [Pubmed]
  6. Adjusting body cell mass for size in women of differing nutritional status. Wells, J.C., Murphy, A.J., Buntain, H.M., Greer, R.M., Cleghorn, G.J., Davies, P.S. Am. J. Clin. Nutr. (2004) [Pubmed]
  7. Bone mineral density in diabetic children and adolescents: a follow-up study. Salvatoni, A., Mancassola, G., Biasoli, R., Cardani, R., Salvatore, S., Broggini, M., Nespoli, L. Bone (2004) [Pubmed]
  8. Complementary feeding with cow's milk alters sleeping metabolic rate in breast-fed infants. Haisma, H., Wells, J.C., Coward, W.A., Filho, D.D., Victora, C.G., Vonk, R.J., Wright, A., Visser, G.H. J. Nutr. (2005) [Pubmed]
  9. Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors. Bakhshi, A., Minowada, J., Arnold, A., Cossman, J., Jensen, J.P., Whang-Peng, J., Waldmann, T.A., Korsmeyer, S.J. N. Engl. J. Med. (1983) [Pubmed]
  10. Ligand-receptor binding revealed by the TNF family member TALL-1. Liu, Y., Hong, X., Kappler, J., Jiang, L., Zhang, R., Xu, L., Pan, C.H., Martin, W.E., Murphy, R.C., Shu, H.B., Dai, S., Zhang, G. Nature (2003) [Pubmed]
  11. Complement facilitates early prion pathogenesis. Klein, M.A., Kaeser, P.S., Schwarz, P., Weyd, H., Xenarios, I., Zinkernagel, R.M., Carroll, M.C., Verbeek, J.S., Botto, M., Walport, M.J., Molina, H., Kalinke, U., Acha-Orbea, H., Aguzzi, A. Nat. Med. (2001) [Pubmed]
  12. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Hutloff, A., Dittrich, A.M., Beier, K.C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., Kroczek, R.A. Nature (1999) [Pubmed]
  13. Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor. Gold, M.R., Law, D.A., DeFranco, A.L. Nature (1990) [Pubmed]
  14. Comparison of a novel assay for breast cancer mucin to CA15-3 and carcinoembryonic antigen. Daly, L., Ferguson, J., Cram, G.P., Hars, V., George, S.L., McCarty, K.S., Bast, R.C. J. Clin. Oncol. (1992) [Pubmed]
  15. Protein requirements of man: obligatory urinary and fecal nitrogen losses in elderly women. Scrimshaw, N.S., Perera, W.D., Young, V.R. J. Nutr. (1976) [Pubmed]
  16. Treatment guidelines for HIV-associated wasting. Nemechek, P.M., Polsky, B., Gottlieb, M.S. Mayo Clin. Proc. (2000) [Pubmed]
  17. Relationships between body composition parameters and fluorouracil pharmacokinetics. Gusella, M., Toso, S., Ferrazzi, E., Ferrari, M., Padrini, R. British journal of clinical pharmacology. (2002) [Pubmed]
  18. Body cell mass in cancer-bearing and anorexic patients. Moley, J.F., Aamodt, R., Rumble, W., Kaye, W., Norton, J.A. JPEN. Journal of parenteral and enteral nutrition. (1987) [Pubmed]
  19. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Yu, G., Boone, T., Delaney, J., Hawkins, N., Kelley, M., Ramakrishnan, M., McCabe, S., Qiu, W.R., Kornuc, M., Xia, X.Z., Guo, J., Stolina, M., Boyle, W.J., Sarosi, I., Hsu, H., Senaldi, G., Theill, L.E. Nat. Immunol. (2000) [Pubmed]
  20. Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. Schneider, P., Takatsuka, H., Wilson, A., Mackay, F., Tardivel, A., Lens, S., Cachero, T.G., Finke, D., Beermann, F., Tschopp, J. J. Exp. Med. (2001) [Pubmed]
  21. Engineering an APRIL-specific B cell maturation antigen. Patel, D.R., Wallweber, H.J., Yin, J., Shriver, S.K., Marsters, S.A., Gordon, N.C., Starovasnik, M.A., Kelley, R.F. J. Biol. Chem. (2004) [Pubmed]
  22. Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis. Kawasaki, A., Tsuchiya, N., Fukazawa, T., Hashimoto, H., Tokunaga, K. Genes Immun. (2001) [Pubmed]
  23. TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. Hatzoglou, A., Roussel, J., Bourgeade, M.F., Rogier, E., Madry, C., Inoue, J., Devergne, O., Tsapis, A. J. Immunol. (2000) [Pubmed]
  24. BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors. Zhang, X., Park, C.S., Yoon, S.O., Li, L., Hsu, Y.M., Ambrose, C., Choi, Y.S. Int. Immunol. (2005) [Pubmed]
  25. Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function. Vora, K.A., Wang, L.C., Rao, S.P., Liu, Z.Y., Majeau, G.R., Cutler, A.H., Hochman, P.S., Scott, M.L., Kalled, S.L. J. Immunol. (2003) [Pubmed]
  26. Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Chiu, A., Xu, W., He, B., Dillon, S.R., Gross, J.A., Sievers, E., Qiao, X., Santini, P., Hyjek, E., Lee, J.W., Cesarman, E., Chadburn, A., Knowles, D.M., Cerutti, A. Blood (2007) [Pubmed]
  27. Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation. Hendriks, J., Planelles, L., de Jong-Odding, J., Hardenberg, G., Pals, S.T., Hahne, M., Spaargaren, M., Medema, J.P. Cell Death Differ. (2005) [Pubmed]
  28. Regulation of B cell maturation and differentiation. I. Suppression of pokeweed mitogen-induced B cell differentiation by tumor necrosis factor (TNF). Kashiwa, H., Wright, S.C., Bonavida, B. J. Immunol. (1987) [Pubmed]
  29. Separation of a population of human T lymphocytes that bind prostaglandin E2 and exert a suppressor activity. Fischer, A., Le Deist, F., Durandy, A., Griscelli, C. J. Immunol. (1985) [Pubmed]
  30. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. Shu, H.B., Johnson, H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  31. A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. Rennert, P., Schneider, P., Cachero, T.G., Thompson, J., Trabach, L., Hertig, S., Holler, N., Qian, F., Mullen, C., Strauch, K., Browning, J.L., Ambrose, C., Tschopp, J. J. Exp. Med. (2000) [Pubmed]
  32. Selective activation of TACI by syndecan-2. Bischof, D., Elsawa, S.F., Mantchev, G., Yoon, J., Michels, G.E., Nilson, A., Sutor, S.L., Platt, J.L., Ansell, S.M., von Bulow, G., Bram, R.J. Blood (2006) [Pubmed]
  33. Potential role of CARMA1 in CD40-induced splenic B cell proliferation and marginal zone B cell maturation. Pappu, B.P., Lin, X. Eur. J. Immunol. (2006) [Pubmed]
  34. Differential effects of low and high concentrations of interleukin 6 on human B cells. Levy, Y., Fermand, J.P., Brouet, J.C. Eur. J. Immunol. (1990) [Pubmed]
  35. Cysteine protease CPP32, but not Ich1-L, is expressed in germinal center B cells and their neoplastic counterparts. Xerri, L., Devilard, E., Ayello, C., Brousset, P., Reed, J.C., Emile, J.F., Hassoun, J., Parmentier, S., Birg, F. Hum. Pathol. (1997) [Pubmed]
  36. Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry. Vidal-Laliena, M., Romero, X., March, S., Requena, V., Petriz, J., Engel, P. Cell. Immunol. (2005) [Pubmed]
  37. The structural basis of hyper IgM deficiency - CD40L mutations. Thusberg, J., Vihinen, M. Protein Eng. Des. Sel. (2007) [Pubmed]
  38. IL-15 mRNA expression is up-regulated in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis (MS). Kivisäkk, P., Matusevicius, D., He, B., Söderström, M., Fredrikson, S., Link, H. Clin. Exp. Immunol. (1998) [Pubmed]
  39. BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes. Gras, M.P., Laâbi, Y., Linares-Cruz, G., Blondel, M.O., Rigaut, J.P., Brouet, J.C., Leca, G., Haguenauer-Tsapis, R., Tsapis, A. Int. Immunol. (1995) [Pubmed]
  40. Stages of B cell differentiation in human lymphoid tissue. Bhan, A.K., Nadler, L.M., Stashenko, P., McCluskey, R.T., Schlossman, S.F. J. Exp. Med. (1981) [Pubmed]
  41. Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells. Kiyoi, H., Naoe, T., Horibe, K., Ohno, R. J. Clin. Invest. (1992) [Pubmed]
  42. Differential attachment of human neoplastic B cells to purified extracellular matrix molecules. Segat, D., Pucillo, C., Marotta, G., Perris, R., Colombatti, A. Blood (1994) [Pubmed]
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