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Gene Review

TRAPPC9  -  trafficking protein particle complex 9

Homo sapiens

Synonyms: IBP, IKBKBBP, KIAA1882, MRT13, NIBP, ...
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Disease relevance of NIBP

  • Early detection rates of hypotension were 60% for invasive methods, 40% for automated non-invasive (NIBP) devices and 30% for manual sphygmomanometry [1].
  • Further characterization of phage T1 DNA clones [2].
  • Inflammatory back pain without AS (IBP) was found in 18% of the patients [3].
  • Typical features of SpA were rare, while fibromyalgia was common in IBP, indicating that IBP is not a precursor or manifestation of SpA in patients with IBD [3].
  • There was no effect of homozygous GST M1 or T1 deletions on melanoma risk [4].

Psychiatry related information on NIBP

  • In contrast, within the CG, paternal parenting stress was negatively associated with adaptive parenting at T1 but showed no enduring negative effects in longitudinal analyses [5].
  • For both groups, there was a direct positive association between T1 use utility and T2 alcohol consumption and an indirect association with T2 alcohol problems via alcohol consumption [6].

High impact information on NIBP

  • As a result, we identified a novel NIK and IKK(beta) binding protein designated NIBP that is mainly expressed in brain, muscle, heart, and kidney [7].
  • Our data demonstrate that NIBP, by interacting with NIK and IKK(beta), is a new enhancer of the cytokine-induced NF-(kappa)B signaling pathway [7].
  • Because of its neuronal expression, we propose that NIBP may be a potential target for modulating the NF-(kappa)B signaling cascade in neuronal pathologies dependent upon abnormal activation of this pathway [7].
  • This IBP is composed of two Ig-like C2 domains, has a molecular mass of 27 kDa, binds human insulin with an affinity of 70 pm, and inhibits insulin signaling through the insulin receptor [8].
  • This binding profile suggests that IBP recognizes a region that is highly conserved in the insulin superfamily but distinct from the classical insulin receptor binding site [8].

Biological context of NIBP

  • The performance of five units of the A&D UA-767 NIBP monitor and five units of the Welch Allyn Spot Vital Signs noninvasive blood pressure monitor was evaluated with the Biotek BP Pump blood pressure simulator under a variety of conditions [9].
  • The results indicate that T1 and T2 share a common leader exon indicative of alternative splicing, and that the genes are uninterrupted by introns in their respective coding sequences [10].
  • Database interrogations also reveal a combined 297 hits of Rtdpoz-like sequences on 7 chromosomes; however, the bulk of the hits (264) and 26 putative TDPOZ-encoding genes, including T1 and T2, are found in a approximately 2.5 Mb cluster in the Rn2_2148 supercontig on chromosome 2 [10].
  • Quantitative analyses indicated that taurine conjugation represents a minor biotransformation pathway for IBP (1.52 +/- 0.43% of the dose over 24 h, n = 4), but it is nonetheless one of mechanistic significance in that it requires the prior formation of the coenzyme A thioester of IBP (IBP-CoA) [11].
  • None of the GST M1 or GST T1 genotypes were significantly associated with the presence of RP among studied VCM workers [12].

Anatomical context of NIBP

  • These findings, together with the results of in vitro experiments with rat liver mitochondrial preparations and isolated rat hepatocytes, demonstrate that although activation of IBP to its CoA thioester favors the R enantiomer over its antipode, S-IBP also participates in CoA-dependent reactions, including metabolic chiral inversion [11].
  • Our results show that exposure to a whole-body average specific absorption rate (SAR) of 2 W/kg, 2 h/day for 4 consecutive weeks does not affect the frequencies of differentiating transitional 1 (T1) and T2 B cells or those of mature follicular B and marginal zone B cells in the spleen [13].

Associations of NIBP with chemical compounds

  • They were monitored with ECG, SPO2, NIBP, expired CO(2), sevoflurane analyzer, and airway pressure [14].
  • Continuous SEF monitoring was added to the standard monitors (SpO2, ETCO2, ECG, NIBP, O2 and isoflurane concentration), but the EEG monitor screen was hidden from the anaesthesiologist's sight [15].
  • HR, NIBP and O2 saturation observed on Datex-Ohmeda multimonitor [16].
  • Following administration of a single oral dose (400 mg) or RS-ibuprofen (RS-IBP) to humans, a novel metabolite was isolated from urine and identified by tandem mass spectrometry as the taurine conjugate of IBP (IBP-Tau) [11].
  • A reversed-phase liquid chromatographic method was developed for 2-(4-isobutylphenyl)propionic acid (IBPP) in bulk drug and compressed tablets containing 100-600 mg of drug per tablet [17].

Analytical, diagnostic and therapeutic context of NIBP

  • We demonstrated by immunohistochemistry that NIBP expression in the brain is localized to neurons [7].
  • All patients were monitored with EKG, NIBP and pulse oximetry (SPO2) during the operation [18].
  • Here we report the molecular cloning of human IBP (IRF-4 binding protein), a new member of this novel family of GEFs [19].
  • The decreases in total lathosterol and methylsterols were more extensive in the IBP group than in the control group [20].
  • We have conducted a case-control study of 58 subjects with RP along with 247 subjects without RP, from a population of 305 French workers exposed or formerly exposed to VCM, to assess any association between GST M1 and GST T1 gene polymorphisms, either separately or in combination, and the presence of RP [12].


  1. The Australian Incident Monitoring Study. Blood pressure monitoring--applications and limitations: an analysis of 2000 incident reports. Cockings, J.G., Webb, R.K., Klepper, I.D., Currie, M., Morgan, C. Anaesthesia and intensive care. (1993) [Pubmed]
  2. Further characterization of phage T1 DNA clones. Liebeschuetz, J., Harris, R.D., Ritchie, D.A. J. Gen. Virol. (1987) [Pubmed]
  3. Prevalence of ankylosing spondylitis and other spondyloarthropathies among patients with inflammatory bowel disease: a population study (the IBSEN study). Palm, O., Moum, B., Ongre, A., Gran, J.T. J. Rheumatol. (2002) [Pubmed]
  4. Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma. M??ssner, R., Anders, N., K??nig, I.R., Kr??ger, U., Schmidt, D., Berking, C., Ziegler, A., Brockm??ller, J., Kaiser, R., Volkenandt, M., Westphal, G.A., Reich, K. Arch. Dermatol. Res. (2007) [Pubmed]
  5. Predictors of Parenting Behavior Trajectories Among Families of Young Adolescents with and without Spina Bifida. Greenley, R.N., Holmbeck, G.N., Rose, B.M. Journal of pediatric psychology (2006) [Pubmed]
  6. An affective and cognitive model of marijuana and alcohol problems. Simons, J.S., Carey, K.B. Addictive behaviors. (2006) [Pubmed]
  7. NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation. Hu, W.H., Pendergast, J.S., Mo, X.M., Brambilla, R., Bracchi-Ricard, V., Li, F., Walters, W.M., Blits, B., He, L., Schaal, S.M., Bethea, J.R. J. Biol. Chem. (2005) [Pubmed]
  8. A new secreted insect protein belonging to the immunoglobulin superfamily binds insulin and related peptides and inhibits their activities. Sloth Andersen, A., Hertz Hansen, P., Schaffer, L., Kristensen, C. J. Biol. Chem. (2000) [Pubmed]
  9. Evaluation of the A&D UA-767 and Welch Allyn Spot Vital Signs noninvasive blood pressure monitors using a blood pressure simulator. Davis, P.D., Dennis, J.L., Railton, R. Journal of human hypertension. (2005) [Pubmed]
  10. Testis-specific expression and genomic multiplicity of the rat Rtdpoz genes that encode bipartite TRAF- and POZ/BTB-domain proteins. Choo, K.B., Hsu, M.C., Chong, K.Y., Huang, C.J. Gene (2007) [Pubmed]
  11. Taurine conjugation of ibuprofen in humans and in rat liver in vitro. Relationship to metabolic chiral inversion. Shirley, M.A., Guan, X., Kaiser, D.G., Halstead, G.W., Baillie, T.A. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  12. Glutathione S-transferase M1 and GST T1 genetic polymorphisms and Raynaud's phenomenon in French vinyl chloride monomer-exposed workers. Fontana, L., Marion, M.J., Ughetto, S., Catilina, P. J. Hum. Genet. (2006) [Pubmed]
  13. Effects of GSM-modulated radiofrequency electromagnetic fields on B-cell peripheral differentiation and antibody production. Nasta, F., Prisco, M.G., Pinto, R., Lovisolo, G.A., Marino, C., Pioli, C. Radiat. Res. (2006) [Pubmed]
  14. Fast track endoscopic thoracic sympathicotomy. Duarte, J.B., Kux, P., Castro, C.H., Cruvinel, M.G., Costa, J.R. Clin. Auton. Res. (2003) [Pubmed]
  15. Influence of the cortical electrical activity level during general anaesthesia on the severity of immediate postoperative pain in the morbidly obese. Gurman, G.M., Popescu, M., Weksler, N., Steiner, O., Avinoah, E., Porath, A. Acta anaesthesiologica Scandinavica. (2003) [Pubmed]
  16. Pain response of neonates to venipuncture. Taksande, A.M., Vilhekar, K.Y., Jain, M., Chitre, D. Indian journal of pediatrics. (2005) [Pubmed]
  17. Determination of 2-(4-isobutylphenyl)propionic acid in bulk drug and compressed tablets by reversed-phase high-performance liquid chromatography. Asmus, P.A. J. Chromatogr. (1985) [Pubmed]
  18. Experience of anesthesia for transthoracic endoscopic sympathectomy in palmar hyperhidrosis--110 cases. Chen, Y.P., Ting, M.C., Hwang, Y.S., Chow, T.C., Lin, J.C. Acta Anaesthesiol. Sin. (1994) [Pubmed]
  19. Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system. Gupta, S., Lee, A., Hu, C., Fanzo, J., Goldberg, I., Cattoretti, G., Pernis, A.B. Hum. Immunol. (2003) [Pubmed]
  20. Pravastatin lowers serum cholesterol, cholesterol-precursor sterols, fecal steroids, and cholesterol absorption in man. Vanhanen, H., Kesäniemi, Y.A., Miettinen, T.A. Metab. Clin. Exp. (1992) [Pubmed]
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