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Gene Review

Akr1c6  -  aldo-keto reductase family 1, member C6

Mus musculus

Synonyms: 17-beta-HSD 5, 3alpha-HSD, Akr1c1, Estradiol 17 beta-dehydrogenase 5, Hsd17b5, ...
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Disease relevance of Akr1c6

  • Moreover, based on the molecular weights and the co-substrate specificities microsomal mouse liver MPON reductase and Pseudomonas 3 alpha-HSD seem to be members of the short-chain alcohol dehydrogenase family [1].

High impact information on Akr1c6


Chemical compound and disease context of Akr1c6


Biological context of Akr1c6

  • The transfection of vectors expressing types 1 and 3 3 alpha-HSD in transformed human embryonic kidney (HEK-293) cells indicates that both enzymes efficiently catalyze the transformation of dihydrotestosterone into 3 alpha-diol in intact cells [3].
  • Based on enzymatic characteristics and sequence homology, it is suggested that type 1 3 alpha-HSD is an ortholog of rat 3 alpha-HSD while type 3 3 alpha-HSD, which must have diverged recently, seems unique to human and is probably more involved in intracrine activity [3].
  • In this report, we describe the isolation of a mouse 3alpha-HSD cDNA and the characterization of its substrate specificity and tissue distribution [4].

Anatomical context of Akr1c6

  • Reversely, MPON reductase purified from mouse liver microsomes and previously characterized as aldehyde reductase, was competitively inhibited by 3 alpha-HSD steroid substrates [1].

Associations of Akr1c6 with chemical compounds

  • The purified enzyme was a 36-kDa monomer, and showed both 17beta-HSD and 3alpha-HSD activities in the presence of NADP(H) as the coenzymes [5].
  • The best known 3 alpha-HSD activity is the transformation of the most potent natural androgen, dihydrotestosterone, into 5 alpha-androstan-3 alpha,17 beta-diol (3 alpha-diol), a compound having much lower activity [3].
  • The mechanism by which fluoxetine and other selective serotonin reuptake inhibitors normalize 3alpha,5alpha-TH PROG CSF levels appears to involve a direct stimulation of 3alpha-hydroxysteroidoxidoreductase (3alpha-HSD), an enzyme that catalyses the reduction of 5alpha-DH PROG into 3alpha,5alpha-TH PROG [6].
  • 5. Synthesis and inactivation of 5alpha-dihydrotestosterone occur through 5alpha-reductase and 3alpha-HSD activities, respectively [7].

Other interactions of Akr1c6

  • The properties of AKR1C20 are distinct from those of previously known mouse 17beta-HSD type 5 (AKR1C6), 3alpha-HSD (AKR1C14) and other members of the AKR1C subfamily [5].

Analytical, diagnostic and therapeutic context of Akr1c6

  • Sequence analysis indicates that m3alpha-HSD shares 87% amino acid identity with rat 3alpha-HSD [4].


  1. Functional and immunological relationships between metyrapone reductase from mouse liver microsomes and 3 alpha-hydroxysteroid dehydrogenase from Pseudomonas testosteroni. Maser, E., Oppermann, U.C., Bannenberg, G., Netter, K.J. FEBS Lett. (1992) [Pubmed]
  2. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Ag??s-Balboa, R.C., Pinna, G., Zhubi, A., Maloku, E., Veldic, M., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. Dufort, I., Labrie, F., Luu-The, V. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  4. Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues. Bellemare, V., Labrie, F., Luu-The, V. J. Steroid Biochem. Mol. Biol. (2006) [Pubmed]
  5. Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family. Matsumoto, K., Endo, S., Ishikura, S., Matsunaga, T., Tajima, K., El-Kabbani, O., Hara, A. Biol. Pharm. Bull. (2006) [Pubmed]
  6. The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders. Guidotti, A., Dong, E., Matsumoto, K., Pinna, G., Rasmusson, A.M., Costa, E. Brain Res. Brain Res. Rev. (2001) [Pubmed]
  7. Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: A marker of lung maturity. Provost, P.R., Tremblay, Y. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
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