The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1L989R     (3R)-10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12...

Synonyms: C03072, 3alpha-Hydroxysteroid
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C03072

  • Molecular cloning, overexpression, and characterization of steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. A novel member of the short-chain dehydrogenase/reductase superfamily [1].
  • Total serum bile acids were estimated by an enzymic (3alpha-hydroxysteroid dehydrogenase) method in 173 fasting patients with different liver diseases, classified into 17 groups by morphological criteria [2].
  • 3Alpha-hydroxysteroid dehydrogenase and delta4-3-ketosteroid-5beta-reductase, both liver-specific enzymes, were reduced in amount in all hepatomas investigated, independent of their mode of induction [3].
  • The culture shares many characteristics with Eubacterium lentum, the neotype strain of which elaborated both 21-dehydroxylase and 3alpha-hydroxysteroid dehydrogenase [4].
  • The dual nucleotide cofactor-specific enzyme, 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) from Pseudomonas sp. B-0831, is a member of the short-chain dehydrogenase/reductase (SDR) superfamily [5].

High impact information on C03072


Chemical compound and disease context of C03072


Biological context of C03072


Anatomical context of C03072


Associations of C03072 with other chemical compounds


Gene context of C03072


Analytical, diagnostic and therapeutic context of C03072


  1. Molecular cloning, overexpression, and characterization of steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. A novel member of the short-chain dehydrogenase/reductase superfamily. Möbus, E., Maser, E. J. Biol. Chem. (1998) [Pubmed]
  2. Bile acids measured in serum during fasting as a test for liver disease. Skrede, S., Solberg, H.E., Blomhoff, J.P., Gjone, E. Clin. Chem. (1978) [Pubmed]
  3. Proteome analysis of rat hepatomas: carcinogen-dependent tumor-associated protein variants. Zeindl-Eberhart, E., Klugbauer, S., Dimitrijevic, N., Jungblut, P.R., Lamer, S., Rabes, H.M. Electrophoresis (2001) [Pubmed]
  4. Isolation and characterization of human fecal bacteria capable of 21-dehydroxylating corticoids. Bokkenheuser, V.D., Winter, J., Dehazya, P., Kelly, W.G. Appl. Environ. Microbiol. (1977) [Pubmed]
  5. Transient-phase kinetic studies on the nucleotide binding to 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831 using fluorescence stopped-flow procedures. Ueda, S., Oda, M., Imamura, S., Ohnishi, M. Eur. J. Biochem. (2004) [Pubmed]
  6. Mechanistic roles of Ser-114, Tyr-155, and Lys-159 in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. Hwang, C.C., Chang, Y.H., Hsu, C.N., Hsu, H.H., Li, C.W., Pon, H.I. J. Biol. Chem. (2005) [Pubmed]
  7. Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties. Chetyrkin, S.V., Belyaeva, O.V., Gough, W.H., Kedishvili, N.Y. J. Biol. Chem. (2001) [Pubmed]
  8. Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence. Jez, J.M., Schlegel, B.P., Penning, T.M. J. Biol. Chem. (1996) [Pubmed]
  9. Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity. Schüle, C., Romeo, E., Uzunov, D.P., Eser, D., di Michele, F., Baghai, T.C., Pasini, A., Schwarz, M., Kempter, H., Rupprecht, R. Mol. Psychiatry (2006) [Pubmed]
  10. Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease. Bauman, D.R., Steckelbroeck, S., Williams, M.V., Peehl, D.M., Penning, T.M. Mol. Endocrinol. (2006) [Pubmed]
  11. Regulation of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase in Comamonas testosteroni: function and relationship of two operators. Xiong, G., Markowetz, S., Maser, E. Chem. Biol. Interact. (2003) [Pubmed]
  12. Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells. Rizner, T.L., Lin, H.K., Penning, T.M. Chem. Biol. Interact. (2003) [Pubmed]
  13. Discrete analysis of bile acid in serum and bile with 3alpha-hydroxysteroid dehydrogenase and diaphorase immobilized onto alkylamine glass beads. Rani, K., Garg, P., Pundir, C.S. Indian J. Biochem. Biophys. (2006) [Pubmed]
  14. Members of the nuclear factor 1 transcription factor family regulate rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD AKR1C9) gene expression: a member of the aldo-keto reductase superfamily. Hung, C.F., Penning, T.M. Mol. Endocrinol. (1999) [Pubmed]
  15. Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate. Jin, Y., Stayrook, S.E., Albert, R.H., Palackal, N.T., Penning, T.M., Lewis, M. Biochemistry (2001) [Pubmed]
  16. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Penning, T.M., Burczynski, M.E., Jez, J.M., Hung, C.F., Lin, H.K., Ma, H., Moore, M., Palackal, N., Ratnam, K. Biochem. J. (2000) [Pubmed]
  17. Quantitative changes in the metabolism of 20alpha-hydroxy-4-pregnen-3-one by rat hypothalamus and pituitary during proestrus. Nowak, F.V., Nuti, K.M., Karavolas, H.J. Steroids (1976) [Pubmed]
  18. Purification, crystallization and preliminary X-ray diffraction results of human 17beta-hydroxysteroid dehydrogenase type 5. Zhou, M., Qiu, W., Chang, H.J., Gangloff, A., Lin, S.X. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
  19. Estren (4-estren-3alpha,17beta-diol) is a prohormone that regulates both androgenic and estrogenic transcriptional effects through the androgen receptor. Centrella, M., McCarthy, T.L., Chang, W.Z., Labaree, D.C., Hochberg, R.B. Mol. Endocrinol. (2004) [Pubmed]
  20. Characterization of the 5alpha-reductase-3alpha-hydroxysteroid dehydrogenase complex in the human brain. Steckelbroeck, S., Watzka, M., Reichelt, R., Hans, V.H., Stoffel-Wagner, B., Heidrich, D.D., Schramm, J., Bidlingmaier, F., Klingmüller, D. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  21. Local androgen inactivation in abdominal visceral adipose tissue. Blouin, K., Richard, C., Bélanger, C., Dupont, P., Daris, M., Laberge, P., Luu-The, V., Tchernof, A. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  22. Partial characterization of the cytosol 3 alpha-hydroxysteroid: NAD(P)+oxidoreductase of rat ventral prostate. Taurog, J.D., Moore, R.J., Wilson, J.D. Biochemistry (1975) [Pubmed]
  23. Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells. Ge, R.S., Hardy, M.P. Endocrinology (1998) [Pubmed]
  24. Sebocytes are the key regulators of androgen homeostasis in human skin. Fritsch, M., Orfanos, C.E., Zouboulis, C.C. J. Invest. Dermatol. (2001) [Pubmed]
  25. Expression of 5alpha-reductase and 3alpha-hydroxisteroid oxidoreductase in the hippocampus of patients with chronic temporal lobe epilepsy. Stoffel-Wagner, B., Beyenburg, S., Watzka, M., Blümcke, I., Bauer, J., Schramm, J., Bidlingmaier, F., Elger, C.E. Epilepsia (2000) [Pubmed]
  26. 5alpha-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. Frye, C.A., Edinger, K.L., Seliga, A.M., Wawrzycki, J.M. Psychoneuroendocrinology (2004) [Pubmed]
  27. Determination of rat muscles androgen-receptor complexes with methyltrienolone. Tremblay, R.R., Dubé, J.Y., Ho-Kim, M.A., Lesage, R. Steroids (1977) [Pubmed]
  28. Characterization of the human aldehyde reductase gene and promoter. Barski, O.A., Gabbay, K.H., Bohren, K.M. Genomics (1999) [Pubmed]
  29. Genomic structure of rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD, AKR1C9). Lin, H.K., Hung, C.F., Moore, M., Penning, T.M. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  30. Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate. Lin, H.K., Steckelbroeck, S., Fung, K.M., Jones, A.N., Penning, T.M. Steroids (2004) [Pubmed]
  31. Neurosteroid metabolism in the human brain. Stoffel-Wagner, B. Eur. J. Endocrinol. (2001) [Pubmed]
  32. Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase. Chetyrkin, S.V., Hu, J., Gough, W.H., Dumaual, N., Kedishvili, N.Y. Arch. Biochem. Biophys. (2001) [Pubmed]
  33. Cloning of the human RoDH-related short chain dehydrogenase gene and analysis of its structure. Kedishvili, N.Y., Belyaeva, O.V., Gough, W.H. Chem. Biol. Interact. (2001) [Pubmed]
  34. Crystallization and preliminary X-ray analysis of the complex of NADH and 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831. Kataoka, S., Nakamura, S., Ohkubo, T., Ueda, S., Uchiyama, S., Kobayashi, Y., Oda, M. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
  35. Convenient non-chromatographic assays for the microbial deconjugation and 7alpha-OH bioconversion of taurocholate. MacDonald, I.A., Bishop, J.M., Mahony, D.E., Williams, C.N. Applied microbiology. (1975) [Pubmed]
WikiGenes - Universities