Disease relevance of SLC10A7

• Plasmid-partition functions of the P7 prophage [1].
• Comparison of the P1 and P7 sequences, and the nature of the junctions between similar and different sequences, suggest that the phages could have evolved by the pickup of divergent cassettes by recombination [1].
• Chemically synthesised human immunodeficiency virus P7 nucleocapsid protein can self-assemble into particles and binds to a specific site on the tRNA(Lys,3) primer [2].

High impact information on SLC10A7

• Each mutation blocked plasmid partition and both were complemented when the P7 ParA and ParB proteins were supplied in trans [1].
• Downstream from the P7 parB open reading frame is a sequence that conserves 27 of the 34 base-pairs of the P1 partition site parS [1].
• The DNA sequence of the P7 region was determined [1].
• The amino acid sequences of the P7 proteins show strong similarities to the P1 ParA and ParB proteins [1].
• The heptamer sequences that define ParB binding sites within P1 parS are represented in P7 but differ from it by one base [1].

Biological context of SLC10A7

• By large-scale sequencing analysis of a human fetal brain cDNA library, we isolated a novel human cDNA (C4orf13) [3].
• Human C4orf13 is mapped to chromosome 4q31.2 and contains 12 exons [3].
• In a previous paper we have characterized five plant peroxidases, P1, P2, P3 and P7 of turnip and horseradish isoperoxidase C by peptide mapping studies, and only found two highly homologous sequences present in all [4].

Anatomical context of SLC10A7

• RT-PCR analysis shows that human C4orf13 is widely expressed in human tissues, and the expression levels in liver and lung are relatively high, expression levels in placenta, kidney, spleen, and thymus are moderate, low levels of expression are detected in heart, prostate, and testis [3].
• The contralateral internal jugular vein was punctured retrogradely and the calibrated P7 sensor was introduced [5].

Associations of SLC10A7 with chemical compounds

• Bromodeoxyuridine-positive cells were detected in the retrolental tissues of postnatal day (P)1, P7, and P14 mice [6].
• Intracellular levels of the P7 protein (a component of the methoxylation system involved in cephamycin biosynthesis) were increased by diaminopropane, as shown by immunoblotting studies [7].
• In P7, however, residue 40 is phenylalanine, a substitution presumably important to its abnormal physio-chemical and enzymic properties [4].
• The P7 provides continuous graphical display of pH, pCO2, and pO2, while temperature, oxygen saturation, HCO3 concentration and base excess are displayed numerically [5].

Analytical, diagnostic and therapeutic context of SLC10A7

• Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family [3].
• Gel filtration profiles of tryptic digests of the turnip isoperoxidases confirm their previous classification into a P1, and P3 group and a distinct P7 enzyme, but further prove the presence of several sites of carbohydrate attachment in P1, P2 and P3 peroxidases, like in horeseradish peroxidase C which has eight sites [4].
• CONCLUSIONS: P7 is useful during carotid endarterectomy providing continuous and "on-line" information on brain metabolism [5].
• In one case, P7 was diagnostic for unsuccessful endarterectomy [5].
• BACKGROUND: The aim of this study is to evaluate the intravascular multiparameter sensor Paratrend 7 (P7) for continuous acid-base and blood gas monitoring after retrograde jugular catheterization during carotid endarterectomy [5].

References