Gene Review:
GNPAT - glyceronephosphate O-acyltransferase
Homo sapiens
Synonyms:
Acyl-CoA:dihydroxyacetonephosphateacyltransferase, DAP-AT, DAPAT, DHAP-AT, DHAPAT, ...
- Abnormal myelin formation in rhizomelic chondrodysplasia punctata type 2 (DHAPAT-deficiency). Sztriha, L., Al-Gazali, L.I., Wanders, R.J., Ofman, R., Nork, M., Lestringant, G.G. Developmental medicine and child neurology. (2000)
- HMG-CoA reductase inhibitors perturb fatty acid metabolism and induce peroxisomes in keratinocytes. Williams, M.L., Menon, G.K., Hanley, K.P. J. Lipid Res. (1992)
- Lipid composition of hepatitis B virus surface antigen particles and the particle-producing human hepatoma cell lines. Satoh, O., Umeda, M., Imai, H., Tunoo, H., Inoue, K. J. Lipid Res. (1990)
- Congenital rubella syndrome associated with calcific epiphyseal stippling and peroxisomal dysfunction. Pike, M.G., Applegarth, D.A., Dunn, H.G., Bamforth, S.J., Tingle, A.J., Wood, B.J., Dimmick, J.E., Harris, H., Chantler, J.K., Hall, J.G. J. Pediatr. (1990)
- Deficiency of acyl-CoA: dihydroxyacetone phosphate acyltransferase in patients with Zellweger (cerebro-hepato-renal) syndrome. Schutgens, R.B., Romeyn, G.J., Wanders, R.J., van den Bosch, H., Schrakamp, G., Heymans, H.S. Biochem. Biophys. Res. Commun. (1984)
- Acyl-CoA:dihydroxyacetonephosphate acyltransferase: cloning of the human cDNA and resolution of the molecular basis in rhizomelic chondrodysplasia punctata type 2. Ofman, R., Hettema, E.H., Hogenhout, E.M., Caruso, U., Muijsers, A.O., Wanders, R.J. Hum. Mol. Genet. (1998)
- Leishmania major expresses a single dihydroxyacetone phosphate acyltransferase localized in the glycosome, important for rapid growth and survival at high cell density and essential for virulence. Zufferey, R., Ben Mamoun, C. J. Biol. Chem. (2006)
- A Single Nucleotide Polymorphism Fine Mapping Study of Chromosome 1q42.1 Reveals the Vulnerability Genes for Schizophrenia, GNPAT and DISC1: Association with Impairment of Sustained Attention. Liu, Y.L., Fann, C.S., Liu, C.M., Chen, W.J., Wu, J.Y., Hung, S.I., Chen, C.H., Jou, Y.S., Liu, S.K., Hwang, T.J., Hsieh, M.H., Ouyang, W.C., Chan, H.Y., Chen, J.J., Yang, W.C., Lin, C.Y., Lee, S.F., Hwu, H.G. Biol. Psychiatry (2006)
- Effect of hypoxia-reoxygenation on peroxisomal functions in cultured human skin fibroblasts from control and Zellweger syndrome patients. Kremser, K., Kremser-Jezik, M., Singh, I. Free Radic. Res. (1995)
- The cerebro-hepato-renal (Zellweger) syndrome: prenatal detection based on impaired biosynthesis of plasmalogens. Schutgens, R.B., Schrakamp, G., Wanders, R.J., Heymans, H.S., Moser, H.W., Moser, A.E., Tager, J.M., Bosch, H.V., Aubourg, P. Prenat. Diagn. (1985)
- Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids. Liu, D., Nagan, N., Just, W.W., Rodemer, C., Thai, T.P., Zoeller, R.A. J. Lipid Res. (2005)
- Biochemical markers predicting survival in peroxisome biogenesis disorders. Gootjes, J., Mooijer, P.A., Dekker, C., Barth, P.G., Poll-The, B.T., Waterham, H.R., Wanders, R.J. Neurology (2002)
- Novel mutations in the PEX12 gene of patients with a peroxisome biogenesis disorder. Gootjes, J., Schmohl, F., Waterham, H.R., Wanders, R.J. Eur. J. Hum. Genet. (2004)
- Prenatal diagnosis of rhizomelic chondrodysplasia punctata due to isolated alkyldihydroacetonephosphate acyltransferase synthase deficiency. Brookhyser, K.M., Lipson, M.H., Moser, A.B., Moser, H.W., Lachman, R.S., Rimoin, D.L. Prenat. Diagn. (1999)
- Measurement of dihydroxyacetone-phosphate acyltransferase (DHAPAT) in chorionic villous samples, blood cells and cultured cells. Wanders, R.J., Ofman, R., Romeijn, G.J., Schutgens, R.B., Mooijer, P.A., Dekker, C., van den Bosch, H. J. Inherit. Metab. Dis. (1995)
- Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes. Biermann, J., Just, W.W., Wanders, R.J., Van Den Bosch, H. Eur. J. Biochem. (1999)
- Purification of peroxisomal acyl-CoA: dihydroxyacetonephosphate acyltransferase from human placenta. Ofman, R., Wanders, R.J. Biochim. Biophys. Acta (1994)
- The dihydroxyacetonephosphate pathway for biosynthesis of ether lipids in Leishmania mexicana promastigotes. Heise, N., Opperdoes, F.R. Mol. Biochem. Parasitol. (1997)
- Topography of ether phospholipid biosynthesis. Hardeman, D., van den Bosch, H. Biochim. Biophys. Acta (1989)
- Transformation and characterization of mutant human fibroblasts defective in peroxisome assembly. Okamoto, H., Suzuki, Y., Shimozawa, N., Yajima, S., Masuno, M., Orii, T. Exp. Cell Res. (1992)
- Properties of the enzymes catalyzing the biosynthesis of lysophosphatidate and its ether analog in cultured fibroblasts from Zellweger syndrome patients and normal controls. Webber, K.O., Datta, N.S., Hajra, A.K. Arch. Biochem. Biophys. (1987)
- X-linked dominant chondrodysplasia punctata with decreased dihydroxyacetone phosphate acyltransferase activity. Sato, M., Ishikawa, O., Miyachi, Y. Dermatology (Basel) (1996)
- Peroxisomal function is altered during leishmania infection. Raychaudhury, B., Banerjee, S., Datta, S.C. Med. Sci. Monit. (2003)
- Plasmalogens in the retina: In situ hybridization of dihydroxyacetone phosphate acyltransferase (DHAP-AT) - the first enzyme involved in their biosynthesis - and comparative study of retinal and retinal pigment epithelial lipid composition. Acar, N., Gregoire, S., Andre, A., Juaneda, P., Joffre, C., Bron, A.M., Creuzot-Garcher, C.P., Bretillon, L. Exp. Eye Res. (2007)