The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TRR1  -  thioredoxin-disulfide reductase TRR1

Saccharomyces cerevisiae S288c

Synonyms: D9476.5, Thioredoxin reductase 1, YDR353W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TRR1


High impact information on TRR1


Biological context of TRR1


Anatomical context of TRR1

  • Mitochondrial thioredoxin reductase was purified from bovine adrenal cortex [10].
  • Our data clearly show that mitochondria, which might have originated from symbiotic prokaryotes, contain thioredoxin reductase similar to the cytosolic enzyme and different from the bacterial one [10].

Associations of TRR1 with chemical compounds


Other interactions of TRR1


  1. Crystallization and preliminary X-ray diffraction analysis of NADPH-dependent thioredoxin reductase I from Saccharomyces cerevisiae. Oliveira, M.A., Discola, K.F., Alves, S.V., Barbosa, J.A., Medrano, F.J., Netto, L.E., Guimarães, B.G. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]
  2. The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae. Morgan, B.A., Banks, G.R., Toone, W.M., Raitt, D., Kuge, S., Johnston, L.H. EMBO J. (1997) [Pubmed]
  3. Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks. di Bernardo, D., Thompson, M.J., Gardner, T.S., Chobot, S.E., Eastwood, E.L., Wojtovich, A.P., Elliott, S.J., Schaus, S.E., Collins, J.J. Nat. Biotechnol. (2005) [Pubmed]
  4. The human p53 negative regulatory domain mediates inhibition of reporter gene transactivation in yeast lacking thioredoxin reductase. Merrill, G.F., Dowell, P., Pearson, G.D. Cancer Res. (1999) [Pubmed]
  5. Thioredoxin reductase-dependent inhibition of MCB cell cycle box activity in Saccharomyces cerevisiae. Machado, A.K., Morgan, B.A., Merrill, G.F. J. Biol. Chem. (1997) [Pubmed]
  6. Overexpression of wild type and SeCys/Cys mutant of human thioredoxin reductase in E. coli: the role of selenocysteine in the catalytic activity. Bar-Noy, S., Gorlatov, S.N., Stadtman, T.C. Free Radic. Biol. Med. (2001) [Pubmed]
  7. Reporter gene transactivation by human p53 is inhibited in thioredoxin reductase null yeast by a mechanism associated with thioredoxin oxidation and independent of changes in the redox state of glutathione. Merwin, J.R., Mustacich, D.J., Muller, E.G., Pearson, G.D., Merrill, G.F. Carcinogenesis (2002) [Pubmed]
  8. Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae. Carmel-Harel, O., Stearman, R., Gasch, A.P., Botstein, D., Brown, P.O., Storz, G. Mol. Microbiol. (2001) [Pubmed]
  9. arsRBOCT Arsenic Resistance System Encoded by Linear Plasmid pHZ227 in Streptomyces sp. Strain FR-008. Wang, L., Chen, S., Xiao, X., Huang, X., You, D., Zhou, X., Deng, Z. Appl. Environ. Microbiol. (2006) [Pubmed]
  10. Mitochondrial thioredoxin reductase in bovine adrenal cortex its purification, properties, nucleotide/amino acid sequences, and identification of selenocysteine. Watabe, S., Makino, Y., Ogawa, K., Hiroi, T., Yamamoto, Y., Takahashi, S.Y. Eur. J. Biochem. (1999) [Pubmed]
  11. Yeast genome-wide expression analysis identifies a strong ergosterol and oxidative stress response during the initial stages of an industrial lager fermentation. Higgins, V.J., Beckhouse, A.G., Oliver, A.D., Rogers, P.J., Dawes, I.W. Appl. Environ. Microbiol. (2003) [Pubmed]
  12. GPX2, encoding a phospholipid hydroperoxide glutathione peroxidase homologue, codes for an atypical 2-Cys peroxiredoxin in Saccharomyces cerevisiae. Tanaka, T., Izawa, S., Inoue, Y. J. Biol. Chem. (2005) [Pubmed]
  13. A proteome analysis of the cadmium response in Saccharomyces cerevisiae. Vido, K., Spector, D., Lagniel, G., Lopez, S., Toledano, M.B., Labarre, J. J. Biol. Chem. (2001) [Pubmed]
  14. Insertional mutagenesis in the n-alkane-assimilating yeast Yarrowia lipolytica: generation of tagged mutations in genes involved in hydrophobic substrate utilization. Mauersberger, S., Wang, H.J., Gaillardin, C., Barth, G., Nicaud, J.M. J. Bacteriol. (2001) [Pubmed]
  15. Thioredoxin-dependent peroxide reductase from yeast. Chae, H.Z., Chung, S.J., Rhee, S.G. J. Biol. Chem. (1994) [Pubmed]
  16. Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. Wormley, F.L., Heinrich, G., Miller, J.L., Perfect, J.R., Cox, G.M. Infect. Immun. (2005) [Pubmed]
WikiGenes - Universities