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Gene Review

XKS1  -  xylulokinase

Saccharomyces cerevisiae S288c

Synonyms: G7584, Xylulokinase, Xylulose kinase, YGR194C
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High impact information on XKS1


Biological context of XKS1


Associations of XKS1 with chemical compounds

  • Anaerobic xylose fermentation by recombinant Saccharomyces cerevisiae carrying XYL1, XYL2, and XKS1 in mineral medium chemostat cultures [7].
  • Growth inhibition increased and ethanol yields from xylose decreased with increasing XK activity [3].
  • Overexpression of XYL3 and XKS1 inhibited growth on xylose but did not affect growth on glucose even though XK activities were three times higher in glucose-grown cells [3].
  • Specific xylulose consumption rate was enhanced by the increased specific XK activity, resulting from the introduction of the XKS1 into S. cerevisiae [8].
  • However, overexpression of XKS1 shifted polyol formation from xylitol to arabinitol [9].

Regulatory relationships of XKS1


Other interactions of XKS1

  • The strain expressed XR, XDH, and XK activities of 0.4 to 0.5, 2.7 to 3.4, and 1.5 to 1.7 U/mg, respectively, and was stable for more than 40 generations in continuous fermentations [7].

Analytical, diagnostic and therapeutic context of XKS1


  1. The missing link in the fungal L-arabinose catabolic pathway, identification of the L-xylulose reductase gene. Richard, P., Putkonen, M., Väänänen, R., Londesborough, J., Penttilä, M. Biochemistry (2002) [Pubmed]
  2. Saccharomyces cerevisiae engineered for xylose metabolism exhibits a respiratory response. Jin, Y.S., Laplaza, J.M., Jeffries, T.W. Appl. Environ. Microbiol. (2004) [Pubmed]
  3. Optimal growth and ethanol production from xylose by recombinant Saccharomyces cerevisiae require moderate D-xylulokinase activity. Jin, Y.S., Ni, H., Laplaza, J.M., Jeffries, T.W. Appl. Environ. Microbiol. (2003) [Pubmed]
  4. The YGR194c (XKS1) gene encodes the xylulokinase from the budding yeast Saccharomyces cerevisiae. Rodriguez-Peña, J.M., Cid, V.J., Arroyo, J., Nombela, C. FEMS Microbiol. Lett. (1998) [Pubmed]
  5. Genetically engineered Saccharomyces yeast capable of effective cofermentation of glucose and xylose. Ho, N.W., Chen, Z., Brainard, A.P. Appl. Environ. Microbiol. (1998) [Pubmed]
  6. The complete sequence of a 9037 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII. Arroyo, J., García-Gonzalez, M., García-Saez, M.I., Sánchez, M., Nombela, C. Yeast (1995) [Pubmed]
  7. Anaerobic xylose fermentation by recombinant Saccharomyces cerevisiae carrying XYL1, XYL2, and XKS1 in mineral medium chemostat cultures. Eliasson, A., Christensson, C., Wahlbom, C.F., Hahn-Hägerdal, B. Appl. Environ. Microbiol. (2000) [Pubmed]
  8. Effects of xylulokinase activity on ethanol production from D-xylulose by recombinant Saccharomyces cerevisiae. Lee, T.H., Kim, M.D., Park, Y.C., Bae, S.M., Ryu, Y.W., Seo, J.H. J. Appl. Microbiol. (2003) [Pubmed]
  9. Xylulose fermentation by mutant and wild-type strains of Zygosaccharomyces and Saccharomyces cerevisiae. Eliasson, A., Boles, E., Johansson, B., Osterberg, M., Thevelein, J.M., Spencer-Martins, I., Juhnke, H., Hahn-Hägerdal, B. Appl. Microbiol. Biotechnol. (2000) [Pubmed]
  10. Xylulokinase overexpression in two strains of Saccharomyces cerevisiae also expressing xylose reductase and xylitol dehydrogenase and its effect on fermentation of xylose and lignocellulosic hydrolysate. Johansson, B., Christensson, C., Hobley, T., Hahn-Hägerdal, B. Appl. Environ. Microbiol. (2001) [Pubmed]
  11. Molecular cloning of XYL3 (D-xylulokinase) from Pichia stipitis and characterization of its physiological function. Jin, Y.S., Jones, S., Shi, N.Q., Jeffries, T.W. Appl. Environ. Microbiol. (2002) [Pubmed]
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