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Gene Review

IL18RAP  -  interleukin 18 receptor accessory protein

Homo sapiens

Synonyms: ACPL, AcPL, Accessory protein-like, CD218 antigen-like family member B, CD218b, ...
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Disease relevance of IL18RAP


High impact information on IL18RAP

  • CD48 via both the peptide portion and GPI glycan triggers the binding to IL-18Rbeta, and the IL-18.IL-18Ralpha.CD48.IL-18Rbeta complex induces cellular signaling [4].
  • However, little is known about how IL-18, IL-18Ralpha, and IL-18Rbeta form a high-affinity complex on the cell surface and transduce the signal [4].
  • On the other hand, the acetylation of IL18RAP gene occurred both in TH1 and TH2 cells the similar kinetics and on the same with residues, demonstrating that selective histone acetylation was not universally the case for all TH1-expressed genes [5].
  • Although IL-18R alpha mRNA was constitutively expressed by RA fibroblast-like synoviocytes, IL-18R beta could not be detected, either with or without stimulation with IL-1 or IL-12 [6].
  • IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction [7].

Biological context of IL18RAP


Anatomical context of IL18RAP


Regulatory relationships of IL18RAP


Analytical, diagnostic and therapeutic context of IL18RAP


  1. Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes. Airoldi, I., Raffaghello, L., Cocco, C., Guglielmino, R., Roncella, S., Fedeli, F., Gambini, C., Pistoia, V. Clin. Cancer Res. (2004) [Pubmed]
  2. Human anti-human IL-18 antibody recognizing the IL-18-binding site 3 with IL-18 signaling blocking activity. Hamasaki, T., Hashiguchi, S., Ito, Y., Kato, Z., Nakanishi, K., Nakashima, T., Sugimura, K. J. Biochem. (2005) [Pubmed]
  3. IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis. Bahi, N., Friocourt, G., Carrié, A., Graham, M.E., Weiss, J.L., Chafey, P., Fauchereau, F., Burgoyne, R.D., Chelly, J. Hum. Mol. Genet. (2003) [Pubmed]
  4. Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production. Fukushima, K., Ikehara, Y., Yamashita, K. J. Biol. Chem. (2005) [Pubmed]
  5. Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression. Morinobu, A., Kanno, Y., O'Shea, J.J. J. Biol. Chem. (2004) [Pubmed]
  6. Heterogeneity of response of rheumatoid synovium cell subsets to interleukin-18 in relation to differential interleukin-18 receptor expression. Kawashima, M., Miossec, P. Arthritis Rheum. (2003) [Pubmed]
  7. IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. Wu, C., Sakorafas, P., Miller, R., McCarthy, D., Scesney, S., Dixon, R., Ghayur, T. J. Immunol. (2003) [Pubmed]
  8. Human keratinocytes constitutively produce but do not process interleukin-18. Mee, J.B., Alam, Y., Groves, R.W. Br. J. Dermatol. (2000) [Pubmed]
  9. Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain. Kim, S.H., Reznikov, L.L., Stuyt, R.J., Selzman, C.H., Fantuzzi, G., Hoshino, T., Young, H.A., Dinarello, C.A. J. Immunol. (2001) [Pubmed]
  10. The clinical phenotype in institutionalised adult males with X-linked mental retardation (XLMR). Van Buggenhout, G.J., Trommelen, J.C., Brunner, H.G., Hamel, B.C., Fryns, J. Ann. Genet. (2001) [Pubmed]
  11. Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease. Salvati, V.M., MacDonald, T.T., Bajaj-Elliott, M., Borrelli, M., Staiano, A., Auricchio, S., Troncone, R., Monteleone, G. Gut (2002) [Pubmed]
  12. IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. Sareneva, T., Julkunen, I., Matikainen, S. J. Immunol. (2000) [Pubmed]
  13. IL-18 is produced by prostate cancer cells and secreted in response to interferons. Lebel-Binay, S., Thiounn, N., De Pinieux, G., Vieillefond, A., Debré, B., Bonnefoy, J.Y., Fridman, W.H., Pagès, F. Int. J. Cancer (2003) [Pubmed]
  14. The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma. Reznikov, L.L., Kim, S.H., Zhou, L., Bufler, P., Goncharov, I., Tsang, M., Dinarello, C.A. J. Interferon Cytokine Res. (2002) [Pubmed]
  15. Increased expression of interleukin-18 receptor on T lymphocytes in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation. Fujimori, Y., Yoshimoto, T., Matsui, K., Tsutsui, H., Okamoto, T., Kashiwamura, S., Hada, T., Okamura, H., Kakishita, E., Hara, H., Nakanishi, K. J. Interferon Cytokine Res. (2002) [Pubmed]
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