The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

IL18R1  -  interleukin 18 receptor 1

Homo sapiens

Synonyms: CD218 antigen-like family member A, CD218a, CDw218a, IL-18R-1, IL-18R1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IL18R1


High impact information on IL18R1


Biological context of IL18R1


Anatomical context of IL18R1


Regulatory relationships of IL18R1

  • We show that following in vitro stimulation with N. meningitidis serogroup B (MenB) antigens, approximately 66% of the dividing mucosal CD4(+)CD45RO(+) memory population express the Th1-associated IL18-R while the remainder express CRTH2, a Th2-associated marker [15].

Other interactions of IL18R1


  1. Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes. Airoldi, I., Raffaghello, L., Cocco, C., Guglielmino, R., Roncella, S., Fedeli, F., Gambini, C., Pistoia, V. Clin. Cancer Res. (2004) [Pubmed]
  2. IL18 and IL18R1 polymorphisms, lung CT and fibrosis: a longitudinal study in coal miners. Nadif, R., Mintz, M., Marzec, J., Jedlicka, A., Kauffmann, F., Kleeberger, S.R. Eur. Respir. J. (2006) [Pubmed]
  3. Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B cells. Pagès, F., Galon, J., Karaschuk, G., Dudziak, D., Camus, M., Lazar, V., Camilleri-Broët, S., Lagorce-Pagès, C., Lebel-Binay, S., Laux, G., Fridman, W.H., Henglein, B. Blood (2005) [Pubmed]
  4. Interleukin-18 receptor signaling is not required for autoantibody production and end-organ disease in murine lupus. Lin, L., Peng, S.L. Arthritis Rheum. (2005) [Pubmed]
  5. Heterogeneity of response of rheumatoid synovium cell subsets to interleukin-18 in relation to differential interleukin-18 receptor expression. Kawashima, M., Miossec, P. Arthritis Rheum. (2003) [Pubmed]
  6. IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. Sareneva, T., Julkunen, I., Matikainen, S. J. Immunol. (2000) [Pubmed]
  7. Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. Hoshino, K., Tsutsui, H., Kawai, T., Takeda, K., Nakanishi, K., Takeda, Y., Akira, S. J. Immunol. (1999) [Pubmed]
  8. Purification and characterization of the human interleukin-18 receptor. Torigoe, K., Ushio, S., Okura, T., Kobayashi, S., Taniai, M., Kunikata, T., Murakami, T., Sanou, O., Kojima, H., Fujii, M., Ohta, T., Ikeda, M., Ikegami, H., Kurimoto, M. J. Biol. Chem. (1997) [Pubmed]
  9. Expression and responsiveness of human interleukin-18 receptor (IL-18R) on hematopoietic cell lines. Nakamura, S., Otani, T., Okura, R., Ijiri, Y., Motoda, R., Kurimoto, M., Orita, K. Leukemia (2000) [Pubmed]
  10. Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha. Cardoso, S.P., Keen, L., Bidwell, J. Eur. J. Immunogenet. (2004) [Pubmed]
  11. Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease. Salvati, V.M., MacDonald, T.T., Bajaj-Elliott, M., Borrelli, M., Staiano, A., Auricchio, S., Troncone, R., Monteleone, G. Gut (2002) [Pubmed]
  12. Increased expression of interleukin-18 receptor on T lymphocytes in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation. Fujimori, Y., Yoshimoto, T., Matsui, K., Tsutsui, H., Okamoto, T., Kashiwamura, S., Hada, T., Okamura, H., Kakishita, E., Hara, H., Nakanishi, K. J. Interferon Cytokine Res. (2002) [Pubmed]
  13. The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain? Boutin, H., Kimber, I., Rothwell, N.J., Pinteaux, E. Mol. Neurobiol. (2003) [Pubmed]
  14. IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation. French, A.R., Holroyd, E.B., Yang, L., Kim, S., Yokoyama, W.M. Cytokine (2006) [Pubmed]
  15. Regulation of Th-1 T cell-dominated immunity to Neisseria meningitidis within the human mucosa. Davenport, V., Groves, E., Hobbs, C.G., Williams, N.A., Heyderman, R.S. Cell. Microbiol. (2007) [Pubmed]
  16. IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. Pan, G., Risser, P., Mao, W., Baldwin, D.T., Zhong, A.W., Filvaroff, E., Yansura, D., Lewis, L., Eigenbrot, C., Henzel, W.J., Vandlen, R. Cytokine (2001) [Pubmed]
  17. Cloning and expression of a single-chain Fv fragment specific for the human interleukin 18 receptor. Nishida, Y., Torigoe, K., Aizawa, Y., Okura, T., Mori, T., Yamauchi, H., Tanimoto, T., Ikeda, M., Ikegami, H., Kurimoto, M. Hybridoma (1998) [Pubmed]
WikiGenes - Universities