Disease relevance of IL18R1

• B-CLL and BL cells did not produce bioactive IL-18; and (d) lymphoma B cells displayed heterogeneous expression of either or both IL-18R chain mRNA [1].
• CONCLUSIONS: Dysregulated expression of IL-18 and/or IL-18R in chronic B-cell lymphoproliferative disorders may sometimes contribute to tumor escape from the host immune system [1].
• IL18 and IL18R1 polymorphisms, lung CT and fibrosis: a longitudinal study in coal miners [2].
• Associations of polymorphisms in the genes coding for IL-18 (IL18 /G-656T, C-607A, G-137C, T113G, C127T) and its receptor (IL18R1 /C-69T) with coal workers' pneumoconiosis (CWP) were studied in 200 miners who were examined in 1990, 1994 and 1999 [2].
• Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B cells [3].

High impact information on IL18R1

• We show here that the EBV nuclear antigen EBNA2 induces expression of the 2 chains of the interleukin-18 receptor (IL-18R) in Burkitt lymphoma (BL) cell lines and in nontransformed B cells [3].
• Interleukin-18 receptor signaling is not required for autoantibody production and end-organ disease in murine lupus [4].
• Heterogeneity of response of rheumatoid synovium cell subsets to interleukin-18 in relation to differential interleukin-18 receptor expression [5].
• Here we show that in human NK and T cells IFN-alpha and IL-12 strongly up-regulate mRNA expression of the IL-18R components, accessory protein-like (AcPL) and IL-1R-related protein (IL-1Rrp) [6].
• The binding of murine rIL-18 was not detected in Th1-developing splenic CD4+ T cells isolated from IL-1Rrp-deficient mice [7].

Biological context of IL18R1

• When expressed in COS-1 cells, the cDNA of IL-1Rrp conferred IL-18 binding properties on the cells and the capacity for signal transduction [8].
• Smoking- or dust-adjustment, and stratification on IL18R1 genotype and adjustment for haplotype effects did not change the conclusions [2].
• To further characterize IL-18R, we analyzed IL-18R expression using a series of human hematopoietic cell lines selected from various cell lineages [9].
• Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha [10].

Anatomical context of IL18R1

• IL-1Rrp and AcPL were seen in all samples but were expressed at greater levels in the mucosa of CD patients [11].
• The human IL-18 receptor (IL-18R) was recently identified and was found to be expressed on normal peripheral blood lymphocytes [9].
• Increased expression of interleukin-18 receptor on T lymphocytes in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation [12].
• The recent characterization of putative, new IL-1 ligands and new IL-1 receptor-related molecules leads to the hypothesis that there might be alternative IL-1 signaling pathway(s) in the central nervous system (CNS) [13].
• NK cells constitutively express interleukin-18 receptor alpha and are stimulated by IL-18 to produce IFNgamma [14].

Regulatory relationships of IL18R1

• We show that following in vitro stimulation with N. meningitidis serogroup B (MenB) antigens, approximately 66% of the dividing mucosal CD4(+)CD45RO(+) memory population express the Th1-associated IL18-R while the remainder express CRTH2, a Th2-associated marker [15].

Other interactions of IL18R1

• IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp [16].
• Biochemical studies showed that IL-18R proteins exist as heterogeneous molecules ranging from 60 to 110 kDa [9].
• Cloning and expression of a single-chain Fv fragment specific for the human interleukin 18 receptor [17].

References