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Gene Review

RPL14  -  ribosomal protein L14

Homo sapiens

Synonyms: 60S ribosomal protein L14, CAG-ISL 7, CAG-ISL-7, CTG-B33, L14, ...
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Disease relevance of RPL14


High impact information on RPL14

  • Analysis of sequence covariation using the entire RNase P RNA data set reveals elements of tertiary structure in the RNA; the third nucleotides (underlined) of the GNRA tetraloops L14 and L18 are seen to interact with adjacent Watson-Crick base pairs in helix P8, forming A:G/C or G:A/U base triples [5].
  • This ranges from 145 pseudogenes for RPL21 down to 3 pseudogenes for RPL14 [6].
  • To investigate the interaction between a signal peptide and the lipid bilayer, two kinds of peptides, L8-M5 (L8 = MRL8PLAALG, M5 = KVFER) and L14-M5 (L14 = MRL14PLAALG), were examined in membranes composed of dioleoylphosphatidylcholine (DOPC) [7].
  • In the tested informative cases, loss of heterozygosity (LOH) of RPL14 was observed in 29 out of 68 (43%) tumors [1].
  • The data suggest that alteration of RPL14 occurred frequently in ESCC and might be an earlier event in the tumorigenesis of the esophagus [1].

Chemical compound and disease context of RPL14


Biological context of RPL14


Anatomical context of RPL14


Associations of RPL14 with chemical compounds

  • The polypeptides present in the different eluted fractions were resolved by SDS-PAGE and were either silver stained or analysed by immunoblotting with monoclonal or polyclonal antibodies, respectively, raised against the glucose-binding protein CBP67 and the galactose-binding proteins CBP35 and L14 [14].

Other interactions of RPL14


Analytical, diagnostic and therapeutic context of RPL14


  1. Alteration of RPL14 in squamous cell carcinomas and preneoplastic lesions of the esophagus. Huang, X.P., Zhao, C.X., Li, Q.J., Cai, Y., Liu, F.X., Hu, H., Xu, X., Han, Y.L., Wu, M., Zhan, Q.M., Wang, M.R. Gene (2006) [Pubmed]
  2. Trinucleotide repeat length variation in the human ribosomal protein L14 gene (RPL14): localization to 3p21.3 and loss of heterozygosity in lung and oral cancers. Shriver, S.P., Shriver, M.D., Tirpak, D.L., Bloch, L.M., Hunt, J.D., Ferrell, R.E., Siegfried, J.M. Mutat. Res. (1998) [Pubmed]
  3. Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2. Girod, A., Ried, M., Wobus, C., Lahm, H., Leike, K., Kleinschmidt, J., Deléage, G., Hallek, M. Nat. Med. (1999) [Pubmed]
  4. Crystallization and preliminary X-ray diffraction studies of bacterial ribosomal protein L14. Davies, C., Gerchman, S.E., Kycia, J.H., McGee, K., Ramakrishnan, V., White, S.W. Acta Crystallogr. D Biol. Crystallogr. (1994) [Pubmed]
  5. Comparative analysis of ribonuclease P RNA using gene sequences from natural microbial populations reveals tertiary structural elements. Brown, J.W., Nolan, J.M., Haas, E.S., Rubio, M.A., Major, F., Pace, N.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Identification and analysis of over 2000 ribosomal protein pseudogenes in the human genome. Zhang, Z., Harrison, P., Gerstein, M. Genome Res. (2002) [Pubmed]
  7. Functional signal peptide reduces bilayer thickness of phosphatidylcholine liposomes. Tahara, Y., Murata, M., Ohnishi, S., Fujiyoshi, Y., Kikuchi, M., Yamamoto, Y. Biochemistry (1992) [Pubmed]
  8. Current status of treatment of acute leukemia in adults: an overview of the Memorial experience and review of literature. Clarkson, B.D., Gee, T., Arlin, Z.A., Mertelsmann, R., Kempin, S.J., Dinsmore, R.E., O'Reilly, R.J., Andreeff, M., Berman, E., Little, C. Crit. Rev. Oncol. Hematol. (1986) [Pubmed]
  9. Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4). Tanaka, M., Tanaka, T., Harata, M., Suzuki, T., Mitsui, Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  10. Pharmacognostical studies of cistanchis herba (III) phylogenetic relationship of the cistanche plants based on plastid rps2 gene and rpl16-rpl14 intergenic spacer sequences. Tomari, N., Ishizuka, Y., Moriya, A., Kojima, S., Deyama, T., Mizukami, H., Tu, P. Biol. Pharm. Bull. (2002) [Pubmed]
  11. Heat shock causes diverse changes in the phosphorylation of the ribosomal proteins of mammalian cells. Kennedy, I.M., Burdon, R.H., Leader, D.P. FEBS Lett. (1984) [Pubmed]
  12. The binding sites for Xenopus laevis FIII/YY1 in the first exon of L1 and L14 ribosomal protein genes are dispensable for promoter expression. De Rinaldis, E., Pisaneschi, G., Camacho-Vanegas, O., Beccari, E. Eur. J. Biochem. (1998) [Pubmed]
  13. Structural change of ribosomes during apoptosis: degradation and externalization of ribosomal proteins in doxorubicin-treated Jurkat cells. Nishida, J., Shiratsuchi, A., Nadano, D., Sato, T.A., Nakanishi, Y. J. Biochem. (2002) [Pubmed]
  14. Evidence for a lactose-mediated association between two nuclear carbohydrate-binding proteins. Sève, A.P., Felin, M., Doyennette-Moyne, M.A., Sahraoui, T., Aubery, M., Hubert, J. Glycobiology (1993) [Pubmed]
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