Gene Review:
LGALS3 - lectin, galactoside-binding, soluble, 3
Homo sapiens
Synonyms:
35 kDa lectin, CBP 35, CBP35, Carbohydrate-binding protein 35, GAL3, ...
Tanaka,
Huang,
Nakamura,
Smith,
de la Chapelle,
Pellegata,
Topol,
Kloos,
Iida,
Nagaraja,
Plow,
Prasad,
Wang,
Ozaki,
Andrew Filer,
Magdalena Bik,
Greg N. Parsonage,
John Fitton,
Emily Trebilcock,
Katherine Howlett,
Michelle Cook,
Karim Raza,
David L. Simmons,
Andrew M. C. Thomas,
Mike Salmon,
Dagmar Scheel-Toellner,
Janet M. Lord,
Gabriel A. Rabinovich,
Christopher D. Buckley,
- Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. Prasad, M.L., Pellegata, N.S., Huang, Y., Nagaraja, H.N., de la Chapelle, A., Kloos, R.T. Mod. Pathol. (2005)
- Increased expression of the LGALS3 (galectin 3) gene in human non-small-cell lung cancer. Yoshimura, A., Gemma, A., Hosoya, Y., Komaki, E., Hosomi, Y., Okano, T., Takenaka, K., Matuda, K., Seike, M., Uematsu, K., Hibino, S., Shibuya, M., Yamada, T., Hirohashi, S., Kudoh, S. Genes Chromosomes Cancer (2003)
- Fine-scale SNP map of an 11-kb genomic region at 22q13.1 containing the galectin-1 gene. Iida, A., Ozaki, K., Tanaka, T., Nakamura, Y. J. Hum. Genet. (2005)
- Combined analysis of galectin-3 and BRAFV600E improves the accuracy of fine-needle aspiration biopsy with cytological findings suspicious for papillary thyroid carcinoma. Sapio, M.R., Guerra, A., Posca, D., Limone, P.P., Deandrea, M., Motta, M., Troncone, G., Caleo, A., Vallefuoco, P., Rossi, G., Fenzi, G., Vitale, M. Endocr. Relat. Cancer (2007)
- Endogenous lectins from cultured cells: subcellular localization of carbohydrate-binding protein 35 in 3T3 fibroblasts. Moutsatsos, I.K., Davis, J.M., Wang, J.L. J. Cell Biol. (1986)
- Genetic susceptibility to myocardial infarction and coronary artery disease. Topol, E.J., Smith, J., Plow, E.F., Wang, Q.K. Hum. Mol. Genet. (2006)
- Effects of DNA methylation on galectin-3 expression in pituitary tumors. Ruebel, K.H., Jin, L., Qian, X., Scheithauer, B.W., Kovacs, K., Nakamura, N., Zhang, H., Raz, A., Lloyd, R.V. Cancer Res. (2005)
- Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at region 14q21-22. Raimond, J., Zimonjic, D.B., Mignon, C., Mattei, M., Popescu, N.C., Monsigny, M., Legrand, A. Mamm. Genome (1997)
- UBD, a downstream element of FOXP3, allows the identification of LGALS3, a new marker of human regulatory T cells. Ocklenburg, F., Moharregh-Khiabani, D., Geffers, R., Janke, V., Pfoertner, S., Garritsen, H., Groebe, L., Klempnauer, J., Dittmar, K.E., Weiss, S., Buer, J., Probst-Kepper, M. Lab. Invest. (2006)
- Analyses of Five gallinacin genes and the Salmonella enterica serovar Enteritidis response in poultry. Hasenstein, J.R., Zhang, G., Lamont, S.J. Infect. Immun. (2006)
- Carbohydrate-binding protein 35. I. Properties of the recombinant polypeptide and the individuality of the domains. Agrwal, N., Sun, Q., Wang, S.Y., Wang, J.L. J. Biol. Chem. (1993)
- Signatures of human regulatory T cells: an encounter with old friends and new players. Pfoertner, S., Jeron, A., Probst-Kepper, M., Guzman, C.A., Hansen, W., Westendorf, A.M., Toepfer, T., Schrader, A.J., Franzke, A., Buer, J., Geffers, R. Genome Biol. (2006)
- Identification of an internal gene to the human Galectin-3 gene with two different overlapping reading frames that do not encode Galectin-3. Guittaut, M., Charpentier, S., Normand, T., Dubois, M., Raimond, J., Legrand, A. J. Biol. Chem. (2001)
- Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9. Ochieng, J., Fridman, R., Nangia-Makker, P., Kleiner, D.E., Liotta, L.A., Stetler-Stevenson, W.G., Raz, A. Biochemistry (1994)
- Expression of nuclear lectin carbohydrate-binding protein 35 in human immunodeficiency virus type 1-infected Molt-3 cells. Schröder, H.C., Ushijima, H., Theis, C., Sève, A.P., Hubert, J., Müller, W.E. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. (1995)
- Regulation of the expression of galactoside-binding lectin during human monocytic differentiation. Nangia-Makker, P., Ochieng, J., Christman, J.K., Raz, A. Cancer Res. (1993)
- Role of Galectin-3 in Mast Cell Functions: Galectin-3-Deficient Mast Cells Exhibit Impaired Mediator Release and Defective JNK Expression. Chen, H.Y., Sharma, B.B., Yu, L., Zuberi, R., Weng, I.C., Kawakami, Y., Kawakami, T., Hsu, D.K., Liu, F.T. J. Immunol. (2006)
- Evidence for a lactose-mediated association between two nuclear carbohydrate-binding proteins. Sève, A.P., Felin, M., Doyennette-Moyne, M.A., Sahraoui, T., Aubery, M., Hubert, J. Glycobiology (1993)
- Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis. Zhuo, Y., Chammas, R., Bellis, S.L. J. Biol. Chem. (2008)
- Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. Kahsai, A.W., Cui, J., Kaniskan, H.U., Garner, P.P., Fenteany, G. J. Biol. Chem. (2008)
- Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways. Filer, A., Bik, M., Parsonage, G.N., Fitton, J., Trebilcock, E., Howlett, K., Cook, M., Raza, K., Simmons, D.L., Thomas, A.M., Salmon, M., Scheel-Toellner, D., Lord, J.M., Rabinovich, G.A., Buckley, C.D. Arthritis Rheum. (2009)
- Forssman disaccharide is the specific ligand of a galectin from the sponge Geodia cydonium but does not mediate its binding to nuclear protein np56. Hanisch, F.G., Baldus, S.E., Kümmel, T.A. Glycobiology (1996)
- Phosphorylated galectin-3 mediates tumor necrosis factor-related apoptosis-inducing ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast carcinoma cells. Mazurek, N., Sun, Y.J., Liu, K.F., Gilcrease, M.Z., Schober, W., Nangia-Makker, P., Raz, A., Bresalier, R.S. J. Biol. Chem. (2007)
- Galectin-3 is not an universal marker of malignancy in thyroid nodular disease in children and adolescents. Niedziela, M., Maceluch, J., Korman, E. J. Clin. Endocrinol. Metab. (2002)
- Diagnostic Usefulness of HBME1, Galectin-3, CK19, and CITED1 and Evaluation of Their Expression in Encapsulated Lesions With Questionable Features of Papillary Thyroid Carcinoma. Scognamiglio, T., Hyjek, E., Kao, J., Chen, Y.T. Am. J. Clin. Pathol. (2006)
- The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop. Ramasamy, S., Duraisamy, S., Barbashov, S., Kawano, T., Kharbanda, S., Kufe, D. Mol. Cell (2007)
- Cloning of the cDNA encoding rabbit galectin-3. Gaudin, J.C., Monsigny, M., Legrand, A. Gene (1995)