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Gene Review

SLC16A7  -  solute carrier family 16 (monocarboxylate...

Homo sapiens

Synonyms: MCT 2, MCT2, Monocarboxylate transporter 2, Solute carrier family 16 member 7
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Disease relevance of SLC16A7


High impact information on SLC16A7


Biological context of SLC16A7


Anatomical context of SLC16A7

  • Among other MCT subtypes, only MCT2 was detected in the parietal cell region of the gastric mucosa [5].
  • Human MCT2 mRNA expression was restricted in normal human tissues but widely expressed in cancer cell lines, suggesting that MCT2 may be pre-translationally regulated in neoplasia [1].
  • MCT2 expression was limited to the sarcolemma of a type 1 fiber subset, which varied from <5 to 40%, depending on the specific muscle under study [6].
  • We investigated the immunocytochemical expression of two monocarboxylate transporters, MCT1 and MCT2, in the human visual cortex between 13 and 26 post-ovulatory weeks [7].
  • Our findings suggest that monocarboxylate trafficking between vessels (MCT1), astrocytes (MCT2) and some postmitotic neurons (MCT1) could develop gradually toward 20 gestational weeks (g.w.). These data suggest that lactate or other monocarboxylates could represent a significant energy source for the human visual cortex at this early stage [7].

Associations of SLC16A7 with chemical compounds

  • The predominant MCT in neurons is the high-affinity MCT2, which can only increase its activity to a limited extent in the face of an increased lactate gradient [8].
  • Accordingly, MCT2 or MCT4 is responsible for L-lactic acid efflux by RD cells [9].
  • MCT1, but not MCT2, was sensitive to organomercurial thiol reagents such as p-chloromercuribenzoic acid [3].
  • We investigated whether the membrane domains containing MCT1, MCT2 and MCT4 are spatially related to each other and to other membrane domains, i.e. those containing glutamate receptors [10].
  • The increased MCT2 expression was temporally correlated with an age-related increase in cerebral uptake of ketones, when ketones were made available after injury [2].

Other interactions of SLC16A7

  • The results of these experiments suggest the presence of 2 different transporter isoforms in heart cells, at least one of which is different from the cloned MCT1 and MCT2 [11].
  • MCT2 was localized in the postsynaptic membrane of parallel fiber-Purkinje cell synapses and MCT4 was situated in the membrane of glial cells in the cerebellum [10].

Analytical, diagnostic and therapeutic context of SLC16A7


  1. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. Lin, R.Y., Vera, J.C., Chaganti, R.S., Golde, D.W. J. Biol. Chem. (1998) [Pubmed]
  2. Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats. Prins, M.L., Giza, C.C. Dev. Neurosci. (2006) [Pubmed]
  3. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. Garcia, C.K., Brown, M.S., Pathak, R.K., Goldstein, J.L. J. Biol. Chem. (1995) [Pubmed]
  4. Developmental expression of monocarboxylate transporter in the gerbil inner ear. Okamura, H., Spicer, S.S., Schulte, B.A. Neuroscience (2001) [Pubmed]
  5. Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8. Iwanaga, T., Takebe, K., Kato, I., Karaki, S., Kuwahara, A. Biomed. Res. (2006) [Pubmed]
  6. Relative distribution of three major lactate transporters in frozen human tissues and their localization in unfixed skeletal muscle. Fishbein, W.N., Merezhinskaya, N., Foellmer, J.W. Muscle Nerve (2002) [Pubmed]
  7. Immunocytochemical expression of monocarboxylate transporters in the human visual cortex at midgestation. Fayol, L., Baud, O., Monier, A., Pellerin, L., Magistretti, P., Evrard, P., Verney, C. Brain Res. Dev. Brain Res. (2004) [Pubmed]
  8. Lactate transport and transporters: general principles and functional roles in brain cells. Hertz, L., Dienel, G.A. J. Neurosci. Res. (2005) [Pubmed]
  9. Transport mechanism for L-lactic acid in human myocytes using human prototypic embryonal rhabdomyosarcoma cell line (RD cells). Kobayashi, M., Fujita, I., Itagaki, S., Hirano, T., Iseki, K. Biol. Pharm. Bull. (2005) [Pubmed]
  10. Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system. Bergersen, L., Rafiki, A., Ottersen, O.P. Neurochem. Res. (2002) [Pubmed]
  11. Lactate transport in heart in relation to myocardial ischemia. Halestrap, A.P., Wang, X., Poole, R.C., Jackson, V.N., Price, N.T. Am. J. Cardiol. (1997) [Pubmed]
  12. Vestibular dark cells contain an H+/monocarboxylate- cotransporter in their apical and basolateral membrane. Shimozono, M., Liu, J., Scofield, M.A., Wangemann, P. J. Membr. Biol. (1998) [Pubmed]
  13. Functional evidence for a monocarboxylate transporter (MCT) in strial marginal cells and molecular evidence for MCT1 and MCT2 in stria vascularis. Shimozono, M., Scofield, M.A., Wangemann, P. Hear. Res. (1997) [Pubmed]
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