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Gene Review

SLC16A1  -  solute carrier family 16 (monocarboxylate...

Homo sapiens

Synonyms: HHF7, MCT, MCT 1, MCT1, MCT1D, ...
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Disease relevance of SLC16A1


Psychiatry related information on SLC16A1

  • They were tested in either visual half-field with a percept-genetic test of anxiety and defense mechanisms (the MCT) [6].

High impact information on SLC16A1


Chemical compound and disease context of SLC16A1


Biological context of SLC16A1


Anatomical context of SLC16A1


Associations of SLC16A1 with chemical compounds


Regulatory relationships of SLC16A1


Other interactions of SLC16A1

  • In addition, MCT1 and MCT4 have been shown to interact specifically with OX-47 (CD147), a member of the immunoglobulin superfamily with a single transmembrane helix [13].
  • CONCLUSIONS: These studies demonstrate for the first time that human RPE expresses two proton-coupled monocarboxylate transporters: MCT1 in the apical membrane and MCT3 in the basolateral membrane [16].
  • Immunohistochemical studies confirmed that human MCT1 antibody labeling was confined to the apical membranes, whereas MCT5 antibody staining was restricted to the basolateral membranes of the colonocytes [15].
  • MCT1 was polarized to the apical membrane and MCT4 to the basolateral membrane, whereas GLUT1 was expressed in both membrane domains [16].
  • Expression of MCT proteins in human RPE and ARPE-19 cells was evaluated by immunolocalization and Western blot analysis with isoform-specific anti-peptide antibodies [16].

Analytical, diagnostic and therapeutic context of SLC16A1

  • Expression of MCT transcripts was evaluated by RT-PCR amplification [16].
  • The present histochemical study using in situ hybridization and immunohistochemistry revealed the distribution and subcellular localization of the MCT family in the digestive tract of mice, rats, and humans, comparing these with that of slc5a8 [19].
  • RT-PCR studies and sequence analysis of the PCR product confirmed the expression of MCT1 by ARPE-19 cells [20].
  • METHODS: To test this hypothesis we used the technique of RNA interference to inhibit MCT1 expression specifically, and determined the consequences of this inhibition on the ability of butyrate to exert its recognized effects in vitro using flow cytometry, immunofluorescence, Northern analysis, and Western analysis [21].
  • The immunofluorescence microscopy showed that within a given muscle section, the MCT4 isoform was clearly more abundant in type II fibers than in type I fibers, whereas only minor differences existed in the occurrence of the MCT1 isoform between type I and II fibers [22].


  1. Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. Lambert, D.W., Wood, I.S., Ellis, A., Shirazi-Beechey, S.P. Br. J. Cancer (2002) [Pubmed]
  2. Regulation of intracellular pH in human melanoma: potential therapeutic implications. Wahl, M.L., Owen, J.A., Burd, R., Herlands, R.A., Nogami, S.S., Rodeck, U., Berd, D., Leeper, D.B., Owen, C.S. Mol. Cancer Ther. (2002) [Pubmed]
  3. Transport mechanism for L-lactic acid in human myocytes using human prototypic embryonal rhabdomyosarcoma cell line (RD cells). Kobayashi, M., Fujita, I., Itagaki, S., Hirano, T., Iseki, K. Biol. Pharm. Bull. (2005) [Pubmed]
  4. The H+-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma. Fang, J., Quinones, Q.J., Holman, T.L., Morowitz, M.J., Wang, Q., Zhao, H., Sivo, F., Maris, J.M., Wahl, M.L. Mol. Pharmacol. (2006) [Pubmed]
  5. The precrystalline cytoplasmic granules of alveolar soft part sarcoma contain monocarboxylate transporter 1 and CD147. Ladanyi, M., Antonescu, C.R., Drobnjak, M., Baren, A., Lui, M.Y., Golde, D.W., Cordon-Cardo, C. Am. J. Pathol. (2002) [Pubmed]
  6. Lateralization of defense mechanisms related to creative functioning. Carlsson, I. Scandinavian journal of psychology. (1990) [Pubmed]
  7. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Garcia, C.K., Goldstein, J.L., Pathak, R.K., Anderson, R.G., Brown, M.S. Cell (1994) [Pubmed]
  8. Differential metabolic adaptation to acute and long-term hypoxia in rat primary cortical astrocytes. Véga, C., R Sachleben, L., Gozal, D., Gozal, E. J. Neurochem. (2006) [Pubmed]
  9. Medullary carcinoma of the thyroid. A study of the clinical features and prognostic factors in 161 patients. Saad, M.F., Ordonez, N.G., Rashid, R.K., Guido, J.J., Hill, C.S., Hickey, R.C., Samaan, N.A. Medicine (Baltimore) (1984) [Pubmed]
  10. Expression of the alphaEbeta7 integrin by mast cells in rheumatoid synovium. Gibson, K.A., Kumar, R.K., Tedla, N., Gotis-Graham, I., McNeil, H.P. J. Rheumatol. (2000) [Pubmed]
  11. Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Deora, A.A., Philp, N., Hu, J., Bok, D., Rodriguez-Boulan, E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  12. Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. Manning Fox, J.E., Meredith, D., Halestrap, A.P. J. Physiol. (Lond.) (2000) [Pubmed]
  13. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Halestrap, A.P., Price, N.T. Biochem. J. (1999) [Pubmed]
  14. Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. Hadjiagapiou, C., Schmidt, L., Dudeja, P.K., Layden, T.J., Ramaswamy, K. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  15. Expression and membrane localization of MCT isoforms along the length of the human intestine. Gill, R.K., Saksena, S., Alrefai, W.A., Sarwar, Z., Goldstein, J.L., Carroll, R.E., Ramaswamy, K., Dudeja, P.K. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  16. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. Philp, N.J., Wang, D., Yoon, H., Hjelmeland, L.M. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  17. Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta. Settle, P., Mynett, K., Speake, P., Champion, E., Doughty, I.M., Sibley, C.P., D'Souza, S.W., Glazier, J. Placenta (2004) [Pubmed]
  18. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. Garcia, C.K., Brown, M.S., Pathak, R.K., Goldstein, J.L. J. Biol. Chem. (1995) [Pubmed]
  19. Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8. Iwanaga, T., Takebe, K., Kato, I., Karaki, S., Kuwahara, A. Biomed. Res. (2006) [Pubmed]
  20. Functional activity of a monocarboxylate transporter, MCT1, in the human retinal pigmented epithelium cell line, ARPE-19. Majumdar, S., Gunda, S., Pal, D., Mitra, A.K. Mol. Pharm. (2005) [Pubmed]
  21. The human colonic monocarboxylate transporter Isoform 1: its potential importance to colonic tissue homeostasis. Cuff, M., Dyer, J., Jones, M., Shirazi-Beechey, S. Gastroenterology (2005) [Pubmed]
  22. Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle. Pilegaard, H., Terzis, G., Halestrap, A., Juel, C. Am. J. Physiol. (1999) [Pubmed]
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