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Gene Review

AIM2  -  absent in melanoma 2

Homo sapiens

Synonyms: Absent in melanoma 2, Interferon-inducible protein AIM2, PYHIN4
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Disease relevance of AIM2


High impact information on AIM2

  • In addition, we have localized AIM2 to the long arm of human chromosome 1 (band q22) in a highly conserved region which also contains the known interferon-inducible genes IFI16 and MNDA [4].
  • We demonstrate that the AIM2 gene encodes a transcript of approximately 2 kb which is expressed in spleen, small intestine, and peripheral blood leukocytes [4].
  • The AIM2 gene is a newly identified gene that is not expressed in a human melanoma cell line [1].
  • Interestingly, overexpression of AIM2 in transfected cells retards proliferation and, under reduced serum conditions, increases the susceptibility to cell death [1].
  • Although the AIM2 protein contained many of the conserved structural motifs common to other HIN-200 proteins, the biochemical characteristics of AIM2 and the ability of overexpressed AIM2 to phenocopy the effect of introduction of chromosome 6 in the UACC903 cells had not been assessed [5].

Biological context of AIM2

  • The human HIN-200 family member AIM2 was originally identified in a screen for suppressors of melanoma tumorigenicity following introduction of chromosome 6 into the UACC903 human melanoma cell line [5].
  • These data indicate that AIM2 has many of the biochemical and structural characteristics of HIN-200 proteins, however, its expression is not sufficient to induce a tumor-suppressor-like phenotype [5].
  • Although AIM2 is known to inhibit fibroblast cell growth in vitro, its antitumor activity has not been shown [2].
  • We further showed that AIM2 significantly increased sub-G(1) phase cell population, indicating that AIM2 could induce tumor cell apoptosis [2].
  • The AIM-2 transcript seemed to have retained an intronic sequence based on its alignment with genomic sequences as well as expressed sequence tags [6].

Anatomical context of AIM2


Other interactions of AIM2

  • The human IFN-inducible protein absent in melanoma 2 (AIM2) gene encodes a 39-kDa protein, which contains a 200-amino-acid repeat as a signature of HIN-200 family (hematopoietic IFN-inducible nuclear proteins) [2].

Analytical, diagnostic and therapeutic context of AIM2


  1. Cytoplasmic localization of the interferon-inducible protein that is encoded by the AIM2 (absent in melanoma) gene from the 200-gene family. Choubey, D., Walter, S., Geng, Y., Xin, H. FEBS Lett. (2000) [Pubmed]
  2. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Chen, I.F., Ou-Yang, F., Hung, J.Y., Liu, J.C., Wang, H., Wang, S.C., Hou, M.F., Hortobagyi, G.N., Hung, M.C. Mol. Cancer Ther. (2006) [Pubmed]
  3. AIM-2: a novel tumor antigen is expressed and presented by human glioma cells. Liu, G., Yu, J.S., Zeng, G., Yin, D., Xie, D., Black, K.L., Ying, H. J. Immunother. (2004) [Pubmed]
  4. Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. DeYoung, K.L., Ray, M.E., Su, Y.A., Anzick, S.L., Johnstone, R.W., Trapani, J.A., Meltzer, P.S., Trent, J.M. Oncogene (1997) [Pubmed]
  5. Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. Cresswell, K.S., Clarke, C.J., Jackson, J.T., Darcy, P.K., Trapani, J.A., Johnstone, R.W. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  6. Melanoma-Reactive CD8+ T cells recognize a novel tumor antigen expressed in a wide variety of tumor types. Harada, M., Li, Y.F., El-Gamil, M., Ohnmacht, G.A., Rosenberg, S.A., Robbins, P.F. J. Immunother. (2001) [Pubmed]
  7. Potentially avoidable maternity complications: an indicator of access to prenatal and primary care during pregnancy. Laditka, S.B., Laditka, J.N., Mastanduno, M.P., Lauria, M.R., Foster, T.C. Women & health. (2005) [Pubmed]
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