The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NANOS1  -  nanos homolog 1 (Drosophila)

Homo sapiens

Synonyms: EC_Rep1a, NOS-1, NOS1, Nanos homolog 1, SPGF12
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NANOS1

  • In the context of brain ischemia, the activity of NOS 1 and NOS 2 is broadly deleterious, and their inhibition or inactivation is neuroprotective [1].
  • The effects of ischemia on the activity of NOS 1, a Ca2+-dependent enzyme, are thought to be secondary to reversal of glutamate reuptake at synapses, activation of NMDA receptors, and resulting elevation of intracellular Ca2+ [1].
  • Indeed, expressions of NOS-1 and NOS-3 were frequently observed in EBV associated GCs [2].
  • Concomitant to muscle atrophy, reduced NOS 1 protein and immunostaining was found in VL not in SOL biopsies [3].
  • CONCLUSION: Expression of NOS1 can not serve as a marker for highly malignant tumours in the non-small cell lung carcinomas [4].

High impact information on NANOS1

  • Among those, homologs to forkhead, emx, aristaless, goosecoid, brachyury, wnt and nanos genes are regulated during apical patterning in cnidarians, suggesting that key components of early organizer activity were conserved across evolution and recruited for either anterior, axial, or dorso-ventral patterning in bilaterians [5].
  • Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development [6].
  • E-Cadherin Regulates Human Nanos1, which Interacts with p120ctn and Induces Tumor Cell Migration and Invasion [7].
  • However, the production of nitric oxide in blood vessels by NOS 3, which, like NOS 1, is Ca2+-dependent, causes vasodilatation and improves blood flow in the penumbral region of brain infarcts [1].
  • Translational repression: a duet of Nanos and Pumilio [8].

Chemical compound and disease context of NANOS1


Biological context of NANOS1


Anatomical context of NANOS1

  • These results suggest the possibility that the interaction of PUM2 and NOS1 may play a conserved role in germ cell development and maintenance in humans as in model organisms [11].
  • We also show that in men, the NOS1 and PUM2 proteins are particularly abundant in germline stem cells [11].
  • Dramatically lower NOS 1 immunoreactivity was observed in tumour vascular endothelium (1-3% and 15-20% in tumour and normal groups, respectively) [12].
  • The keratinocytes, which make up the bulk of the epidermis, constitutively express the neuronal isoform of NO synthase (NOS1), whereas the fibroblasts in the dermis and other cell types in the skin express the endothelial isoform (NOS3) [13].
  • NOS-1 is localised primarily to neuronal structures, where NO is a mediator of the inhibitory Non-Adrenergic Non-Cholinergic System and NOS-3 is present in endothelial cells [14].

Associations of NANOS1 with chemical compounds

  • Differences between NOS 1 and NOS 2 production of .NO, O2.-, and H2O2 may define the specific physiologic function of each isozyme [15].
  • In the absence of L-arginine, however, NOS 1 generation of O2.- and H2O2 was found to be substantially greater than that measured for NOS 2 [15].
  • Exposure to Cd increased the levels of hypothalamic NOS1 mRNA at 09:00 hr and decreased the levels of NOS2 mRNA at 01:00 hr, with melatonin treatment preventing Cd effects [16].
  • Paraffin-embedded tissues were stained with hematoxylin and eosin, or with antibodies to NOS1 and p53, and evaluated under light microscope [4].
  • The model, its strengths and its weaknesses are discussed with reference to four examples of functional ncRNA sequences: a riboswitch (guanine), a zipcode (nanos), a splicing factor (U4) and a ribozyme (RNase P) [17].

Other interactions of NANOS1


Analytical, diagnostic and therapeutic context of NANOS1


  1. Oxidative stress in brain ischemia. Love, S. Brain Pathol. (1999) [Pubmed]
  2. Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas. Begnami, M.D., Montagnini, A.L., Vettore, A.L., Nonogaki, S., Brait, M., Simoes-Sato, A.Y., Seixas, A.Q., Soares, F.A. World J. Gastroenterol. (2006) [Pubmed]
  3. Differential expression of nitric oxide synthases (NOS 1-3) in human skeletal muscle following exercise countermeasure during 12 weeks of bed rest. Rudnick, J., Püttmann, B., Tesch, P.A., Alkner, B., Schoser, B.G., Salanova, M., Kirsch, K., Gunga, H.C., Schiffl, G., Lück, G., Blottner, D. FASEB J. (2004) [Pubmed]
  4. Nitric oxide synthase type 1 expression in human lung cancer and its relation to p53. Lewko, B., Zółtowska, A., Stepiński, J., Kamiński, M., Skokowski, J., Roszkiewicz, A., Moszkowska, G. Med. Sci. Monit. (2001) [Pubmed]
  5. Conserved and divergent genes in apex and axis development of cnidarians. Galliot, B. Curr. Opin. Genet. Dev. (2000) [Pubmed]
  6. Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development. Suzuki, A., Tsuda, M., Saga, Y. Development (2007) [Pubmed]
  7. E-Cadherin Regulates Human Nanos1, which Interacts with p120ctn and Induces Tumor Cell Migration and Invasion. Strumane, K., Bonnomet, A., Stove, C., Vandenbroucke, R., Nawrocki-Raby, B., Bruyneel, E., Mareel, M., Birembaut, P., Berx, G., van Roy, F. Cancer Res. (2006) [Pubmed]
  8. Translational repression: a duet of Nanos and Pumilio. Parisi, M., Lin, H. Curr. Biol. (2000) [Pubmed]
  9. Establishment of a novel human squamous cell carcinoma cell line from oral primary tumor by geneticin treatment. Ji, Z.W., Oku, N., Komori, T. The Kobe journal of medical sciences. (2000) [Pubmed]
  10. vasa and nanos expression patterns in a sea anemone and the evolution of bilaterian germ cell specification mechanisms. Extavour, C.G., Pang, K., Matus, D.Q., Martindale, M.Q. Evol. Dev. (2005) [Pubmed]
  11. Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells. Jaruzelska, J., Kotecki, M., Kusz, K., Spik, A., Firpo, M., Reijo Pera, R.A. Dev. Genes Evol. (2003) [Pubmed]
  12. Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium. Aliev, G., Smith, M.A., Seyidova, D., Neal, M.L., Shi, J., Loizidou, M., Turmaine, M., Friedland, R.P., Taylor, I., Burnstock, G., Perry, G., Lamanna, J.C. J. Submicrosc. Cytol. Pathol. (2002) [Pubmed]
  13. Nitric oxide function in the skin. Cals-Grierson, M.M., Ormerod, A.D. Nitric Oxide (2004) [Pubmed]
  14. Mediators of asthma: nitric oxide. Fischer, A., Folkerts, G., Geppetti, P., Groneberg, D.A. Pulmonary pharmacology & therapeutics. (2002) [Pubmed]
  15. A comparative study of neuronal and inducible nitric oxide synthases: generation of nitric oxide, superoxide, and hydrogen peroxide. Weaver, J., Porasuphatana, S., Tsai, P., Pou, S., Roman, L.J., Rosen, G.M. Biochim. Biophys. Acta (2005) [Pubmed]
  16. In vivo protective effect of melatonin on cadmium-induced changes in redox balance and gene expression in rat hypothalamus and anterior pituitary. Poliandri, A.H., Esquifino, A.I., Cano, P., Jiménez, V., Lafuente, A., Cardinali, D.P., Duvilanski, B.H. J. Pineal Res. (2006) [Pubmed]
  17. A probabilistic model for the evolution of RNA structure. Holmes, I. BMC Bioinformatics (2004) [Pubmed]
  18. Mechanisms of translational control by the 3' UTR in development and differentiation. de Moor, C.H., Meijer, H., Lissenden, S. Semin. Cell Dev. Biol. (2005) [Pubmed]
  19. Mineralization of matrix vesicles isolated from a human osteosarcoma cell line in culture with water-soluble chitosan-containing medium. Yamada, S., Ohara, N., Hayashi, Y. Journal of biomedical materials research. Part A. (2003) [Pubmed]
WikiGenes - Universities