Disease relevance of Polychondritis, Relapsing

• Thymoma, myasthenia gravis, and relapsing polychondritis [1].
• We suggest that the finding of CSF pleocytosis in relapsing polychondritis does not merit empiric antimicrobial therapy in the absence of demonstrated infection [2].
• Tracheal stenosis due to relapsing polychondritis in rheumatoid arthritis [3].
• These data suggest that the ocular manifestations of relapsing polychondritis, especially nodular and necrotizing scleritis, are less amenable to treatment with systemic corticosteroids and/or dapsone and that more potent immunosuppressants (azathioprine and cyclophosphamide) may be required to treat these lesions successfully [4].
• Type II collagen induces an erosive polyarthritis in certain strains of rats, mice, and higher primates which can resemble rheumatoid arthritis and relapsing polychondritis [5].

High impact information on Polychondritis, Relapsing

• In addition, we show that complement factor 5 is important for the induction of matrilin-1-induced relapsing polychondritis [6].
• Autoreactivity against matrilin-1 in a patient with relapsing polychondritis [7].
• Antibodies were found in the sera of 15% of the RA patients and 50% of the relapsing polychondritis patients, as well as in the cartilage of 69% of the RA patients examined [8].
• Relapsing polychondritis. A feature of systemic lupus erythematosus [9].
• The association of relapsing polychondritis with CSF pleocytosis is reported for the first time [2].

Chemical compound and disease context of Polychondritis, Relapsing

• Increased subglottic gallium uptake in relapsing polychondritis [10].
• Steroid sparing effect of methotrexate in relapsing polychondritis [11].
• Treatment of relapsing polychondritis with dapsone [12].
• Pulse intravenous cyclophosphamide for kidney disease in relapsing polychondritis [13].
• Colchicine and indomethacin for the treatment of relapsing polychondritis [14].

Anatomical context of Polychondritis, Relapsing

• Approximately 50% of patients with scleritis are known to be associated with systemic connective tissue diseases or vasculitic diseases such as rheumatoid arthritis (RA), Wegener's granulomatosis, relapsing polychondritis, and systemic lupus erythematosus [15].

Gene context of Polychondritis, Relapsing

• The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis [16].
• Lack of association of HLA-A and B locus antigens with relapsing polychondritis [17].
• In this article, the spectrum of respiratory disease caused by systemic lupus erythematosus, rheumatoid arthritis, scleroderma, polymyositis/dermatomyositis, mixed connective tissue disease, ankylosing spondylitis, relapsing polychondritis, and Sjögren's syndrome is reviewed [18].
• Refractory relapsing polychondritis: rapid and sustained response in the treatment with an IL-1 receptor antagonist (anakinra) [19].
• Pulmonary function in patients with relapsing polychondritis [20].

Analytical, diagnostic and therapeutic context of Polychondritis, Relapsing

• These results suggest that gallium scintigraphy is valuable for evaluating inflammatory activity in relapsing polychondritis [10].
• Cartilage antibodies were demonstrated by indirect immunofluorescence (IFL) on human fetal cartilage in 6 out of 9 patients with relapsing polychondritis (RPC), in 4 out of 260 patients with rheumatoid arthritis (RA), and in only 1 out of 1016 patients with other disorders [21].
• A bandlike pattern resembling systemic lupus erythematosus immunofluorescence in a case of relapsing polychondritis [22].
• Sera from six patients with relapsing polychondritis and one patient with microscopic polyarteritis nodosa as well as from six controls were analyzed by immunoblotting and ELISA [23].

References