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Gene Review

Matn1  -  matrilin 1, cartilage matrix protein

Mus musculus

Synonyms: CMP, Cartilage matrix protein, Cmp, Crtm, Mat1, ...
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Disease relevance of Matn1


High impact information on Matn1

  • These data suggest that matrilin 1 is not critically required for cartilage structure and function and that matrilin 1 and matrilin 3 may have functionally redundant roles [6].
  • Although matrilin 1 interacts with the collagen II and aggrecan networks of cartilage, suggesting that it may play a role in cartilage tissue organization, studies of collagen extractability indicated that collagen fibril maturation and covalent cross-linking were unaffected by the absence of matrilin 1 [6].
  • Matrilin 1, or cartilage matrix protein, is a member of a novel family of extracellular matrix proteins [6].
  • In addition, we show that complement factor 5 is important for the induction of matrilin-1-induced relapsing polychondritis [7].
  • Mice deficient of B cells (muMT) and mice congenic at the complement factor 5, were immunized with matrilin-1, a cartilage-specific protein mainly detected in the tracheal cartilage [7].

Biological context of Matn1


Anatomical context of Matn1

  • In the developing limb bud, both matrilin-1 and -3 were observed first at day 12.5 p.c. Throughout development matrilin-3 expression was strictly limited to cartilage, while matrilin-1 was also found in some other forms of connective tissue [11].
  • We investigated the response to matrilin 1 and other cartilage proteins in sera from patients with RP, 4 additional groups of patients with other major connective tissue diseases, and healthy control subjects [1].
  • Ultrastructural studies of the cartilage of growth plates of matrilin-1 null mice reveal an abnormal type II collagen fibrillogenesis and fibril organization in the matrix of the zone of maturation [3].
  • As in all known matrilin genes, the last intron, separating the exons coding for the coiled-coil domain, does not follow the GT-AG rule and belongs to the subgroup of introns having AT-AC at the ends that are spliced by the U12-type spliceosome [12].
  • To investigate the binding properties and tissue selection of matrilin-1-specific antibodies we produced matrilin-1-specific B-cell hybridomas [7].

Associations of Matn1 with chemical compounds

  • Finally, mice lacking matrilin-1, a non-collagenous glycoprotein that binds to both collagen fibrils and aggrecan, develop normally without detectable abnormalities in their skeleton [13].

Physical interactions of Matn1

  • Highly conserved proximal promoter element harbouring paired Sox9-binding sites contributes to the tissue- and developmental stage-specific activity of the matrilin-1 gene [14].

Regulatory relationships of Matn1

  • Matrilin-1 is transiently expressed in the heart between days 9.5 and 14.5 p.c. Matrilin-2 expression was detected in the heart from day 10.5 p.c. onwards [11].

Other interactions of Matn1


Analytical, diagnostic and therapeutic context of Matn1

  • Recombinantly expressed full-length matrilin-3 occurs as monomers, dimers, trimers, and tetramers, as detected by electron microscopy and SDS-polyacrylamide gel electrophoresis, whereas matrilin-3, purified from fetal calf cartilage, forms homotetramers as well as hetero-oligomers of variable stoichiometry with matrilin-1 [18].


  1. The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis. Hansson, A.S., Heinegård, D., Piette, J.C., Burkhardt, H., Holmdahl, R. Arthritis Rheum. (2001) [Pubmed]
  2. Sequence, structure and chromosomal localization of Crtm gene encoding mouse cartilage matrix protein and its exclusion as a candidate for murine achondroplasia. Aszódi, A., Beier, D.R., Hiripi, L., Bösze, Z., Fässler, R. Matrix Biol. (1998) [Pubmed]
  3. Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organization. Huang, X., Birk, D.E., Goetinck, P.F. Dev. Dyn. (1999) [Pubmed]
  4. Animal models of inflammatory spinal and sacroiliac joint diseases. Zhang, Y. Rheum. Dis. Clin. North Am. (2003) [Pubmed]
  5. Evidence of a linkage between matrilin-1 gene (MATN1) and idiopathic scoliosis. Montanaro, L., Parisini, P., Greggi, T., Di Silvestre, M., Campoccia, D., Rizzi, S., Arciola, C.R. Scoliosis (2006) [Pubmed]
  6. Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage? Aszódi, A., Bateman, J.F., Hirsch, E., Baranyi, M., Hunziker, E.B., Hauser, N., Bösze, Z., Fässler, R. Mol. Cell. Biol. (1999) [Pubmed]
  7. Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. Hansson, A.S., Johannesson, M., Svensson, L., Nandakumar, K.S., Heinegård, D., Holmdahl, R. Am. J. Pathol. (2004) [Pubmed]
  8. Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis. van der Weyden, L., Wei, L., Luo, J., Yang, X., Birk, D.E., Adams, D.J., Bradley, A., Chen, Q. Am. J. Pathol. (2006) [Pubmed]
  9. Effects of overexpression of membrane-bound transferrin-like protein (MTf) on chondrogenic differentiation in Vitro. Suardita, K., Fujimoto, K., Oda, R., Shimazu, A., Miyazaki, K., Kawamoto, T., Kato, Y. J. Biol. Chem. (2002) [Pubmed]
  10. Matrilin-4, a new member of the matrilin family of extracellular matrix proteins. Wagener, R., Kobbe, B., Paulsson, M. FEBS Lett. (1998) [Pubmed]
  11. Expression of matrilin-1, -2 and -3 in developing mouse limbs and heart. Segat, D., Frie, C., Nitsche, P.D., Klatt, A.R., Piecha, D., Korpos, E., Deák, F., Wagener, R., Paulsson, M., Smyth, N. Matrix Biol. (2000) [Pubmed]
  12. Structure and mapping of the mouse matrilin-3 gene (Matn3), a member of a gene family containing a U12-type AT-AC intron. Wagener, R., Kobbe, B., Aszódi, A., Liu, Z., Beier, D.R., Paulsson, M. Mamm. Genome (2000) [Pubmed]
  13. The role of collagen II and cartilage fibril-associated molecules in skeletal development. Aszódi, A., Hunziker, E.B., Olsen, B.R., Fässler, R. Osteoarthr. Cartil. (2001) [Pubmed]
  14. Highly conserved proximal promoter element harbouring paired Sox9-binding sites contributes to the tissue- and developmental stage-specific activity of the matrilin-1 gene. Rentsendorj, O., Nagy, A., Sinkó, I., Daraba, A., Barta, E., Kiss, I. Biochem. J. (2005) [Pubmed]
  15. Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities. Mátés, L., Nicolae, C., Mörgelin, M., Deák, F., Kiss, I., Aszódi, A. Matrix Biol. (2004) [Pubmed]
  16. Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage. Kanbe, K., Inoue, K., Xiang, C., Chen, Q. Modern rheumatology / the Japan Rheumatism Association. (2006) [Pubmed]
  17. Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice. Hansson, A.S., Johansson, A.C., Holmdahl, R. Arthritis Res. Ther. (2004) [Pubmed]
  18. Molecular structure and tissue distribution of matrilin-3, a filament-forming extracellular matrix protein expressed during skeletal development. Klatt, A.R., Nitsche, D.P., Kobbe, B., Mörgelin, M., Paulsson, M., Wagener, R. J. Biol. Chem. (2000) [Pubmed]
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