Disease relevance of Carcinoma, Acinar Cell

• In addition, rat acinar cell carcinomas were used to compare cytokeratin expression in ductal vs. acinar cell pancreatic carcinomas [1].
• The distribution pattern of neoplasia in 343 explants examined after 10 weeks of DMN treatment was as follows: 79% resembled ductal cell carcinoma; 9%, ductal hyperplasia; and 3%, acinar cell carcinoma [2].
• Chronic pancreatitis (n = 7), serous cystadenomas (n = 5), benign mucinous cystic neoplasms (n = 4), neuroendocrine cancer (n = 1), and acinar cell carcinoma (n = 1) had no detectable telomerase activity [3].
• A total of 59 infiltrating PDACs, 32 specimens from patients with chronic pancreatitis, 11 endocrine tumours and 24 acinar cell carcinomas were immunohistochemically analysed for ADAM9 expression [4].
• Clinical setting, cytomorphologic features, and immunostains of the cell block help distinguish SPTP from pancreatic endocrine tumors, acinar cell carcinoma, and papillary mucinous carcinoma [5].

High impact information on Carcinoma, Acinar Cell

• Coexpression of TGF alpha and c-myc also accelerated tumor growth in situ and produced transplantable acinar cell carcinomas whose rate of growth was TGF alpha dependent [6].
• Four spontaneous acinar cell carcinomas of pancreas were also found in 10- to 18-month-old CB1 fish [7].
• Demonstration of kallikrein in a rat pancreatic acinar cell carcinoma [8].
• Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway [9].
• Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation [10].

Chemical compound and disease context of Carcinoma, Acinar Cell

• Azaserine and MNCO have induced acinar cell carcinomas in rats [11].
• The results indicate that altered glycoprotein and lipid compositions represent some of the characteristic features of the acinar cell carcinoma [12].
• Production of pancreatic acinar cell carcinoma by combined administration of 4-hydroxyaminoquinoline 1-oxide and azaserine in partial pancreatectomized rats [13].
• Estrogen and testosterone receptors were assayed, but high-affinity receptors characteristic of gonadal tissues were not detected in normal pancreas or in a transplantable azaserine-induced acinar cell carcinoma [14].
• Acinar cell carcinoma of rat pancreas: mechanism of deregulation of cholesterol metabolism [15].

Anatomical context of Carcinoma, Acinar Cell

• Such tumors include mucin-hyper-secreting carcinoma, serous microcystic neoplasm, mucinous macrocystic neoplasm, solid and papillary epithelial neoplasm, multiple cysts associated with von Hippel-Lindau disease, acinar cell carcinoma, pancreaticoblastoma, and endocrine neoplasms (eg, nonfunctioning islet cell tumors, insulinoma, and gastrinoma) [16].

Gene context of Carcinoma, Acinar Cell

• Staining for ADAM9 was detected in 58 out of 59 (98.3%) PDACs and in two out of 24 (8.3%) acinar cell carcinomas, but not in endocrine tumours [4].
• An acinar cell carcinoma showed cells focally immunoreactive for CMG and CEA [17].
• Finally, we show that the p53 protein in acinar cell carcinomas is wild type in conformation [18].
• AFP production in pancreatic tumors is closely linked to acinar differentiation, most cases representing either pancreatoblastoma or acinar cell carcinoma [19].
• Ductal adenocarcinomas of the hamster pancreas have similar mutations, but acinar cell carcinomas of the mouse and rat pancreas lack the common c-Ki-ras mutations [20].

Analytical, diagnostic and therapeutic context of Carcinoma, Acinar Cell

• The main differential diagnosis of this tumour was acinar cell carcinoma, because both tumours have a number of features in common (scattered solid components, positivity for pancreatic enzymes, lack of p53 overexpression and of Ki-ras mutation) [21].
• Locally advanced acinar cell carcinoma of the pancreas successfully treated by capecitabine and concurrent radiotherapy: report of two cases [22].
• A 41-year-old man with a huge pancreatic tumor (acinar cell carcinoma) was treated by intra-arterial infusion chemotherapy with 5-fluorouracil (5-FU), mitomycin C (MMC) and cisplatin (CDDP) [23].

References