Disease relevance of Amnesia, Retrograde

• When measured under the contingencies of a one trial passive avoidance paradigm, nimodipine is able to prevent the occurrence of retrograde amnesia in rodents after amnesiogenic events such as maximal electroconvulsive seizure or hypoxia [1].

Psychiatry related information on Amnesia, Retrograde

• METHODS: We studied the effect of indomethacin (4 mg/kg/day) administered daily for 19 days on retrograde amnesia induced by two once-daily electroconvulsive shocks in rats [2].
• Bilateral infusion of lactacystin, a specific proteasome inhibitor, to the CA1 region caused full retrograde amnesia for a one-trial inhibitory avoidance learning when given 1, 4 or 7h, but not 10 h, after training [3].
• Benzodiazepine has produced only anterograde amnesia and it has not produced retrograde amnesia [4].
• These results indicate that MS patients exhibit retrograde amnesia that cannot be attributed to anterograde memory deficits or lack of exposure to task-relevant information [5].
• To exemplify this heterogeneity of amnesic symptoms, the anterograde and retrograde amnesias of patients with Huntington's Disease (HD) and of patients with alcoholic Korsakoff's syndrome are compared [6].

High impact information on Amnesia, Retrograde

• Memory: proline induces retrograde amnesia in chicks [7].
• Memory protective effect of indomethacin against electroconvulsive shock-induced retrograde amnesia in rats [2].
• In a new experiment reported here, we show that N-methyl-D-aspartate (NMDA)-induced hippocampal damage produced retrograde amnesia for both hidden platform and two-choice visible platform discriminations in the Morris water task [8].
• BACKGROUND: Midazolam and propofol often provoke retrograde amnesia after recovery from anesthesia in humans [9].
• The authors examined whether isoflurane provides retrograde amnesia for classic (Pavlovian) fear conditioning [10].

Chemical compound and disease context of Amnesia, Retrograde

• The post-training administration of ACTH1-24 (0.2 microgram/kg), human beta-endorphin (1.0 microgram/kg) or epinephrine HC1 (5.0 micrograms/kg), intraperitoneally, caused retrograde amnesia for a step-down inhibitory avoidance task in rats, and their pre-testing administration reversed this effect [11].
• Intravenously injected midazolam was associated with a greater degree of sedation, as assessed by 24-h retrograde amnesia, than the longer acting benzodiazepine, diazepam [12].
• Pentylenetetrazol-induced retrograde amnesia was reversed by AVP-(1-9) and various C-terminal fragments [13].
• Bilateral infusion of AP5 or muscimol caused retrograde amnesia when given 0 min after training into both hippocampus and amygdala, when given or 180 min after training into the entorhinal cortex, or when given 180 min after training into the parietal cortex [14].
• Nefiracetam prevents propofol-induced anterograde and retrograde amnesia in the rodent without compromising quality of anesthesia [15].

Anatomical context of Amnesia, Retrograde

• Novelty causes time-dependent retrograde amnesia for one-trial avoidance in rats through NMDA receptor- and CaMKII-dependent mechanisms in the hippocampus [16].
• Reduction of ECS-induced retrograde amnesia of passive avoidance conditioning after 5,7-dihydroxytryptamine median raphe nucleus lesion in the rat [17].
• We now report that in the Wistar rat, intrastriatal post-training injection of microgram quantities of bicuculine or picrotoxin, two GABA antagonists with different modes of action, induced retrograde amnesia of inhibitory avoidance, in concordance with the effects of injections of picrotoxin into the substantia nigra [18].

Gene context of Amnesia, Retrograde

• In the present study the effects of somatostatin and its analogs on active avoidance behavior, electroconvulsive shock (ECS)-induced retrograde amnesia, and spatial-discrimination learning were compared in rats [19].
• Administration of inhibitors of the Erk cascade worsened retrograde amnesia, impaired performances in hippocampus- and amygdala-dependent memory tasks, and exacerbated motor deficits following TBI [20].
• Recently, we were able to demonstrate that the intrahippocampal infusion of a specific inhibitor of CAMK II (KN62) provoked full retrograde amnesia of an inhibitory avoidance learning in rats when given immediately, but not 120 or 240 min, after training [21].
• The similar pattern of remote memory performance demonstrated by the HIV-D and HD groups is a novel finding and suggests a subcortically mediated retrograde amnesia in HIV-D [22].
• Intrahippocampal, but not intra-amygdala, infusion of an inhibitor of heme oxygenase causes retrograde amnesia in the rat [23].

Analytical, diagnostic and therapeutic context of Amnesia, Retrograde

• Differential effects of Ketaset/Rompun anesthesia on hypothermia-induced retrograde amnesia and its recovery [24].

References