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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Amnesia, Retrograde

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Disease relevance of Amnesia, Retrograde

  • When measured under the contingencies of a one trial passive avoidance paradigm, nimodipine is able to prevent the occurrence of retrograde amnesia in rodents after amnesiogenic events such as maximal electroconvulsive seizure or hypoxia [1].

Psychiatry related information on Amnesia, Retrograde


High impact information on Amnesia, Retrograde


Chemical compound and disease context of Amnesia, Retrograde


Anatomical context of Amnesia, Retrograde


Gene context of Amnesia, Retrograde

  • In the present study the effects of somatostatin and its analogs on active avoidance behavior, electroconvulsive shock (ECS)-induced retrograde amnesia, and spatial-discrimination learning were compared in rats [19].
  • Administration of inhibitors of the Erk cascade worsened retrograde amnesia, impaired performances in hippocampus- and amygdala-dependent memory tasks, and exacerbated motor deficits following TBI [20].
  • Recently, we were able to demonstrate that the intrahippocampal infusion of a specific inhibitor of CAMK II (KN62) provoked full retrograde amnesia of an inhibitory avoidance learning in rats when given immediately, but not 120 or 240 min, after training [21].
  • The similar pattern of remote memory performance demonstrated by the HIV-D and HD groups is a novel finding and suggests a subcortically mediated retrograde amnesia in HIV-D [22].
  • Intrahippocampal, but not intra-amygdala, infusion of an inhibitor of heme oxygenase causes retrograde amnesia in the rat [23].

Analytical, diagnostic and therapeutic context of Amnesia, Retrograde


  1. Behavioral effects of nimodipine in animals. Hoffmeister, F., Benz, U., Heise, A., Krause, H.P., Neuser, V. Arzneimittel-Forschung. (1982) [Pubmed]
  2. Memory protective effect of indomethacin against electroconvulsive shock-induced retrograde amnesia in rats. Rao, S.K., Andrade, C., Reddy, K., Madappa, K.N., Thyagarajan, S., Chandra, S. Biol. Psychiatry (2002) [Pubmed]
  3. The ubiquitin-proteasome cascade is required for mammalian long-term memory formation. Lopez-Salon, M., Alonso, M., Vianna, M.R., Viola, H., Mello e Souza, T., Izquierdo, I., Pasquini, J.M., Medina, J.H. Eur. J. Neurosci. (2001) [Pubmed]
  4. Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. Saraf, M.K., Kishore, K., Thomas, K.M., Sharma, A., Singh, M. Behav. Brain Res. (2003) [Pubmed]
  5. Autobiographical memory in multiple sclerosis. Paul, R.H., Blanco, C.R., Hames, K.A., Beatty, W.W. Journal of the International Neuropsychological Society : JINS. (1997) [Pubmed]
  6. The clinical aspects of memory disorders: contributions from experimental studies of amnesia and dementia. Butters, N. Journal of clinical neuropsychology. (1984) [Pubmed]
  7. Memory: proline induces retrograde amnesia in chicks. Cherkin, A., Eckardt, M.J., Gerbrandt, L.K. Science (1976) [Pubmed]
  8. Retrograde amnesia after hippocampal damage: recent vs. remote memories in two tasks. Sutherland, R.J., Weisend, M.P., Mumby, D., Astur, R.S., Hanlon, F.M., Koerner, A., Thomas, M.J., Wu, Y., Moses, S.N., Cole, C., Hamilton, D.A., Hoesing, J.M. Hippocampus. (2001) [Pubmed]
  9. Facilitation of serotonergic activity and amnesia in rats caused by intravenous anesthetics. Semba, K., Adachi, N., Arai, T. Anesthesiology (2005) [Pubmed]
  10. Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioning. Dutton, R.C., Maurer, A.J., Sonner, J.M., Fanselow, M.S., Laster, M.J., Eger, E.I. Anesthesiology (2002) [Pubmed]
  11. Involvement of alpha-adrenergic receptors in the amnestic and anti-amnestic action of ACTH, beta-endorphin and epinephrine. Izquierdo, I., Dias, R.D. Psychoneuroendocrinology (1984) [Pubmed]
  12. Short report: sedation for upper gastrointestinal endoscopy--diazepam versus midazolam. Gilvarry, J.M., Craig, M., Fielding, J.F. Aliment. Pharmacol. Ther. (1990) [Pubmed]
  13. Structure activity relationship studies with C-terminal fragments of vasopressin and oxytocin on avoidance behaviors of rats. de Wied, D., Gaffori, O., Burbach, J.P., Kovács, G.L., van Ree, J.M. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  14. Sequential role of hippocampus and amygdala, entorhinal cortex and parietal cortex in formation and retrieval of memory for inhibitory avoidance in rats. Izquierdo, I., Quillfeldt, J.A., Zanatta, M.S., Quevedo, J., Schaeffer, E., Schmitz, P.K., Medina, J.H. Eur. J. Neurosci. (1997) [Pubmed]
  15. Nefiracetam prevents propofol-induced anterograde and retrograde amnesia in the rodent without compromising quality of anesthesia. O'Gorman, D.A., O'Connell, A.W., Murphy, K.J., Moriarty, D.C., Shiotani, T., Regan, C.M. Anesthesiology (1998) [Pubmed]
  16. Novelty causes time-dependent retrograde amnesia for one-trial avoidance in rats through NMDA receptor- and CaMKII-dependent mechanisms in the hippocampus. Izquierdo, I., Schröder, N., Netto, C.A., Medina, J.H. Eur. J. Neurosci. (1999) [Pubmed]
  17. Reduction of ECS-induced retrograde amnesia of passive avoidance conditioning after 5,7-dihydroxytryptamine median raphe nucleus lesion in the rat. Montanaro, N., Dall'Olio, R., Gandolfi, O. Neuropsychobiology (1981) [Pubmed]
  18. Post-training injection of GABAergic antagonists into the striatum produces retrograde amnesia. Chávez, M.E., Salado-Castillo, R., Sánchez-Alavez, M., Quirarte, G.L., Prado-Alcalá, R.A. Neurobiology of learning and memory. (1995) [Pubmed]
  19. Somatostatin and (D-Trp8, D-Cys14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats. Vécsei, L., Bollók, I., Penke, B., Telegdy, G. Psychoneuroendocrinology (1986) [Pubmed]
  20. The role of extracellular signal-regulated kinase in cognitive and motor deficits following experimental traumatic brain injury. Dash, P.K., Mach, S.A., Moore, A.N. Neuroscience (2002) [Pubmed]
  21. Learning-specific, time-dependent increases in hippocampal Ca2+/calmodulin-dependent protein kinase II activity and AMPA GluR1 subunit immunoreactivity. Cammarota, M., Bernabeu, R., Levi De Stein, M., Izquierdo, I., Medina, J.H. Eur. J. Neurosci. (1998) [Pubmed]
  22. Retrograde amnesia in dementia: comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease. Sadek, J.R., Johnson, S.A., White, D.A., Salmon, D.P., Taylor, K.I., Delapena, J.H., Paulsen, J.S., Heaton, R.K., Grant, I. Neuropsychology. (2004) [Pubmed]
  23. Intrahippocampal, but not intra-amygdala, infusion of an inhibitor of heme oxygenase causes retrograde amnesia in the rat. Fin, C., Schmitz, P.K., Da Silva, R.C., Bernabeu, R., Medina, J.H., Izquierdo, I. Eur. J. Pharmacol. (1994) [Pubmed]
  24. Differential effects of Ketaset/Rompun anesthesia on hypothermia-induced retrograde amnesia and its recovery. Metzger, M.M., Riccio, D.C. Neurobiology of learning and memory. (1995) [Pubmed]
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