Disease relevance of Meningitis, Meningococcal

• Clearly, the presence of succinic acid that can be rapidly detected by GLC in the CSF excludes pneumococcal or meningococcal meningitis and strongly suggests H. influenzae or other bacillary meningitides [1].
• The por A gene, which encodes expression of meningococcal class 1 outer membrane protein, responsible for antigenic subtype specificity, has been cloned and sequenced in an isolate of Neisseria meningitidis (B:15:P1.7,16) from a patient in the Gloucester area with meningococcal meningitis [2].
• Thyroxine, triiodothyronine and thyrotrophin levels in meningococcal meningitis, typhoid fever and other febrile conditions [3].
• We report the use of intracranial pressure monitoring, mild hypothermia and barbiturate coma in a patient with meningococcal meningitis complicated by raised intracranial pressure [4].
• Persistent low C3 levels associated with meningococcal meningitis and membranoproliferative glomerulonephritis [5].

High impact information on Meningitis, Meningococcal

• CONCLUSIONS: The high-level chloramphenicol resistance that we describe in N. meningitidis isolates is of great concern, since in developing countries, chloramphenicol given intramuscularly is the standard therapy for meningococcal meningitis [6].
• Penicillin G in the dosage studied is adequate therapy for most streptococcal and meningococcal meningitis in children; an increased dosage may be necessary when the minimal inhibitory concentration of penicillin to the etiologic agent is unusually high [7].
• To investigate the role of coincident respiratory viral and mycoplasmal agents in the pathogenesis of meningococcal meningitis, we performed a matched case-control study of 62 patients with group A meningococcal meningitis during an epidemic in Chad [8].
• We report the case of an 18-year-old man with meningococcal meningitis and low serum concentrations of mannose-binding lectin (MBL) [9].
• Polymerase chain reaction for diagnosis of meningococcal meningitis [10].

Chemical compound and disease context of Meningitis, Meningococcal

• Comparison of gram stain and latex agglutination for diagnosis of meningococcal meningitis [11].
• Nitric oxide synthesis in meningococcal meningitis [12].
• Chronic meningococcal meningitis. An association with C5 deficiency [13].
• Recently, we studied a group of 30 patients who experienced a large number of side-effects after receiving minocycline for treatment of meningococcal meningitis [14].
• There is no efficient vaccine against group B meningococcal meningitis because of tolerance induced by host tissue polysialic acid cross-reacting with the capsular polysaccharide [15].

Gene context of Meningitis, Meningococcal

• We investigated the temporal and spatial mRNA expression pattern of gelatinase B in experimental meningococcal meningitis in rats [16].
• Rapid diagnosis of meningococcal meningitis by polymerase chain reaction [17].
• Serum samples taken on admission from 79 patients with meningococcal meningitis, septicaemia, or both, were examined in a highly sensitive bioassay for tumour necrosis factor (TNF) [18].
• Hereditary dysfunction of the third component of complement associated with a systemic lupus erythematosus-like syndrome and meningococcal meningitis [19].
• Recurrent meningococcal meningitis with occult CSF leak [20].

Analytical, diagnostic and therapeutic context of Meningitis, Meningococcal

• Serum specimens obtained from culture-positive group A meningococcal meningitis patients in Cairo, Egypt were tested for immunoglobulin M (IgM) antibodies to Neisseria meningitidis group A polysaccharide by direct and IgM capture enzyme-linked immunosorbent assays (ELISAs) [21].
• Convalescent sera from meningococcal meningitis patients contained antibodies which, on Western blots, recognized the Tbps2s of both pathogens [22].
• The 1990 meningococcal meningitis epidemic of Sarh (Chad): how useful was an earlier mass vaccination [23]?
• AUTHORS' CONCLUSIONS: For the first year after vaccination, the polysaccharide serogroup A vaccine was strongly protective against serogroup A meningococcal meningitis in participants over five years of age [24].
• Recently we experienced an 11-yr-old girl with meningococcal meningitis who was diagnosed as having C7 deficiency based upon the undetectable serum C7 protein on radial immunodiffusion and the undetectable serum total and C7 hemolytic activities [25].

References