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Chemical Compound Review

Vidarabine     (2R,3S,4S,5R)-2-(6- aminopurin-9-yl)-5...

Synonyms: Vira-A, Ara-A, alpha-Ara A, beta-Ara A, Ara A, ...
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Disease relevance of Adenine arabinoside


High impact information on Adenine arabinoside


Chemical compound and disease context of Adenine arabinoside


Biological context of Adenine arabinoside


Anatomical context of Adenine arabinoside


Associations of Adenine arabinoside with other chemical compounds


Gene context of Adenine arabinoside


Analytical, diagnostic and therapeutic context of Adenine arabinoside


  1. Carbocyclic arabinofuranosyladenine (cyclaradine): efficacy against genital herpes in guinea pigs. Vince, R., Daluge, S., Lee, H., Shannon, W.M., Arnett, G., Schafer, T.W., Nagabhushan, T.L., Reichert, P., Tsai, H. Science (1983) [Pubmed]
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  3. S-adenosylhomocysteine catabolism and basis for acquired resistance during treatment of T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin alone and in combination with 9-beta-D-arabinofuranosyladenine. Hershfield, M.S., Kredich, N.M., Koller, C.A., Mitchell, B.S., Kurtzberg, J., Kinney, T.R., Falletta, J.M. Cancer Res. (1983) [Pubmed]
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  6. Influence of 9-beta-D-arabinofuranosyladenine on total protein synthesis and on differential gene expression of unique proteins in the rodent malarial parasite Plasmodium berghei. Ilan, J., Pierce, D.R., Miller, F.W. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  7. Antiviral activity of a conjugate of adenine-9-beta-D-arabinofuranoside 5'-monophosphate and a 9 kDa fragment of arabinogalactan. Josephson, L., Rutkowski, J.V., Paul, K., Frigo, T., Korba, B.E., Tennant, B., Groman, E.V. Antivir. Ther. (Lond.) (1996) [Pubmed]
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  10. Sequence-specific inhibition of DNA strand elongation by incorporation of 9-beta-D-arabinofuranosyladenine. Ohno, Y., Spriggs, D., Matsukage, A., Ohno, T., Kufe, D. Cancer Res. (1989) [Pubmed]
  11. Chemotherapy of herpetic keratitis induced by acyclovir-resistant strains of herpes simplex virus type 1. O'Brien, W.J., Taylor, J.L. Am. J. Med. (1982) [Pubmed]
  12. Comparison of the efficacy of vidarabine, its carbocyclic analog (cyclaradine), and cyclaradine-5'-methoxyacetate in the treatment of herpes simplex virus type 1 encephalitis in mice. Shannon, W.M., Westbrook, L., Arnett, G., Daluge, S., Lee, H., Vince, R. Antimicrob. Agents Chemother. (1983) [Pubmed]
  13. Erythro-9-(2-hydroxy-3-nonyl) Adenine alone and in combination with 9-beta-D-arabinofuranosyladenine in treatment of systemic herpesvirus infections in mice. Shannon, W.M., Arnett, G., Schabel, F.M., North, T.W., Cohen, S.S. Antimicrob. Agents Chemother. (1980) [Pubmed]
  14. Susceptibility of bovid herpesvirus 1 to antiviral drugs: in vitro versus in vivo efficacy of (E)-5-(2-Bromovinyl)-2'-deoxyuridine. Babiuk, L.A., Acres, S.D., Misra, V., Stockdale, P.H., De Clercq, E. Antimicrob. Agents Chemother. (1983) [Pubmed]
  15. Therapeutic effects of 9-beta-D-arabinofuranosyladenine and 2'-deoxycoformycin combinations on intracerebral leukemia. Lee, S.H., Caron, N., Kimball, A.P. Cancer Res. (1977) [Pubmed]
  16. Sensitization of noncycling human diploid cells to X-irradiation by pretreatment with 9-beta-D-arabinofuranosyladenine. Little, J.B., Dahlberg, W.K. Cancer Res. (1989) [Pubmed]
  17. Correlation of cytotoxicity with total intracellular exposure to 9-beta-D-arabinofuranosyladenine 5'-triphosphate. Shewach, D.S., Plunkett, W. Cancer Res. (1982) [Pubmed]
  18. Unusual sensitivity to bleomycin and joint resistance to 9-beta-D-arabinofuranosyladenine and 1-beta-D-arabinofuranosylcytosine of mouse FM3A cell mutants with altered ribonucleotide reductase and thymidylate synthase. Ayusawa, D., Iwata, K., Seno, T. Cancer Res. (1983) [Pubmed]
  19. Gene expression of herpes simplex virus. II. UV radiological analysis of viral transcription units. Millette, R.L., Klaiber, R. J. Virol. (1980) [Pubmed]
  20. Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases. Verhoef, V., Sarup, J., Fridland, A. Cancer Res. (1981) [Pubmed]
  21. Determinants of deoxyadenosine toxicity in hybrids between human T- and B- lymphoblasts as a model for the development of drug resistance in T-cell acute lymphoblastic leukemia. Kurtzberg, J., Hershfield, M.S. Cancer Res. (1985) [Pubmed]
  22. Inhibition of nuclear envelope nucleoside triphosphatase-regulated nucleocytoplasmic messenger RNA translocation by 9-beta-D-arabinofuranosyladenine 5'-triphosphate in rodent cells. Schröder, H.C., Nitzgen, D.E., Bernd, A., Kurelec, B., Zahn, R.K., Gramzow, M., Müller, W.E. Cancer Res. (1984) [Pubmed]
  23. Effects of 2'-deoxyadenosine, 9-beta-D-arabinofuranosyladenine, and related compounds on S-adenosyl-L-homocysteine hydrolase activity in synchronous and asynchronous cultured cells. Cass, C.E., Selner, M., Ferguson, P.J., Phillips, J.R. Cancer Res. (1982) [Pubmed]
  24. Relationship between aberrant DNA replication and loss of cell viability in Chinese hamster ovary CHO-K1 cells. Woodcock, D.M., Adams, J.K., Cooper, I.A. Cancer Res. (1982) [Pubmed]
  25. Antiproliferative effects of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and related compounds in combination with adenosine deaminase inhibitors against mouse leukemia L1210/C2 cells in culture. Cass, C.E., Tan, T.H., Selner, M. Cancer Res. (1979) [Pubmed]
  26. S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in various tissues of mice given injections of 9-beta-D-arabinofuranosyladenine. Helland, S., Ueland, P.M. Cancer Res. (1983) [Pubmed]
  27. Relative cytotoxicity of 9-beta-D-arabinofuranosyladenine and 9-beta-D-arabinofuranosyladenine 5'-monophosphate. Juranka, P., Chan, V.L. Cancer Res. (1980) [Pubmed]
  28. Fludarabine phosphate (NSC 312878) infusions for the treatment of acute leukemia: phase I and neuropathological study. Spriggs, D.R., Stopa, E., Mayer, R.J., Schoene, W., Kufe, D.W. Cancer Res. (1986) [Pubmed]
  29. Inactivation of S-adenosylhomocysteine hydrolase by 9-beta-D-arabinofuranosyladenine in intact cells. Helland, S., Ueland, P.M. Cancer Res. (1982) [Pubmed]
  30. Changes in sensitivity to anticancer drugs during TPA-induced cellular differentiation in a human T-lymphoblastoid cell line (MOLT-4). Takimoto, T., Kubota, M., Tsuruta, S., Kitoh, T., Tanizawa, A., Akiyama, Y., Kiriyama, Y., Mikawa, H. Leukemia (1988) [Pubmed]
  31. Reactivation of S-adenosylhomocysteine hydrolase activity in cells exposed to 9-beta-D-arabinofuranosyladenine. Helland, S., Ueland, P.M. Cancer Res. (1982) [Pubmed]
  32. Metabolism and chemotherapeutic activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine against murine leukemia L1210 and evidence for its phosphorylation by deoxycytidine kinase. Brockman, R.W., Cheng, Y.C., Schabel, F.M., Montgomery, J.A. Cancer Res. (1980) [Pubmed]
  33. Column-switching high-performance liquid chromatographic method for determination of a new antiviral agent, cyclaradine, in serum. Lim, J.M., Lin, C.C. Antimicrob. Agents Chemother. (1986) [Pubmed]
  34. Drug targeting in antiviral chemotherapy. A chemically stable conjugate of 9-beta-D-arabinofuranosyl-adenine 5'-monophosphate with lactosaminated albumin accomplishes a selective delivery of the drug to liver cells. Fiume, L., Bassi, B., Busi, C., Mattioli, A., Spinosa, G. Biochem. Pharmacol. (1986) [Pubmed]
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