Disease relevance of Phimosis

• Outflow obstruction secondary to the phimosis appears to have caused pyelonephritis, and renal inflammation decreased responsiveness to aldosterone transiently [1].
• This study was undertaken to determine the minimum effective dose of granisetron, 5-hydroxytryptamine type 3 receptor antagonist, for the prevention of post-operative vomiting in children undergoing general inhalational anaesthesia for surgery (inguinal hernia and phimosis) [2].
• PATIENT(S): Infertile patients with radiologic or laparoscopic diagnosis of hydrosalpinx (n = 11) or tubal phimosis (n = 12) as the only cause of infertility, and fertile controls (n = 17) [3].
• METHODS: Foreskin fibroblasts were obtained from three boys with phimosis (control subjects), three patients with Reifenstein syndrome and one patient with 5alpha-reductase deficiency (due to mutation L113P in exon 2 of the SRD5A2 gene) [4].

High impact information on Phimosis

• MATERIALS AND METHODS: A total of 70 boys 1 to 12 years old with phimosis were randomly assigned to receive topical application of either betamethasone valerate 0.06% (a highly potent steroid) or clobetasone butyrate 0.05% (a moderately potent steroid) [5].
• Ninety-six percent of patients receiving 1 or more cycles of betamethasone showed complete resolution of phimosis [6].
• No eye developed ACO or phimosis [7].
• OBJECTIVE: The aim of this study was to evaluate the efficacy of topical applications of clobetasol propionate cream in the treatment of phimosis in boys and a comparison of the results presented with an overview of the current studies [8].
• Capsulorhexis phimosis in retinitis pigmentosa despite capsular tension ring implantation [9].

Chemical compound and disease context of Phimosis

• Topical steroid treatment of phimosis in boys [10].
• CONCLUSION: The AcrySof lens with PMMA haptics produced significantly less anterior capsule movement than PMMA or silicone lenses and thus is likely to cause less IOL decentration and capsular phimosis [11].
• METHODS: EMLA cream was applied 1 hour before surgery (fremulum plasty, circumcision or dorsal section for phimosis, and condyloma accuminatum) in addition to a subcutaneous infiltration of lidocaine 1%, just before incision in cases of circumcision [12].
• Treatment with triamcinoloneacetonide and etretinate ameliorated the phimosis but the patient was still not comfortable and circumcision was performed [13].
• CONCLUSION: Conjugated equine estrogen ointment application for phimosis may be an alternative to surgery [14].

Anatomical context of Phimosis

• MAIN OUTCOME MEASURE(S): Histologic score (HSCORE) on luminal and glandular endometrium of the patients with hydrosalpinx or tubal phimosis and the normal fertile controls [3].
• The median HSCORE for beta3 subunit expression in luminal epithelium for tubal phimosis, hydrosalpinx, and fertile controls was 0.07 +/- 0.06, 0.21 +/- 0.18, and 1.03 +/- 0.31, respectively [3].

Gene context of Phimosis

• Tubal abnormalities included tubal sacculations, diverticulae, convolutions, phimosis, fimbrial agglutination, and peritubal adhesions [15].
• CONCLUSION(S): The endometrial expression of beta3 integrin subunit is reduced in the presence of tubal phimosis or hydrosalpinx, during the window of implantation [3].
• True phimosis accompanied 81.5% of the SCC cases [16].

Analytical, diagnostic and therapeutic context of Phimosis

• RESULTS: The mean pre-treatment phimosis grades in the steroid and control groups were 5.08+/-0.66 and 4.97+/-0.70, respectively [17].
• METHODS: Twenty-six patients with phimosis were operated on by preputial plasty, under local anesthesia with EMLA cream [18].

References