Gene Review:
SRD5A2 - steroid-5-alpha-reductase, alpha...
Homo sapiens
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2, 5 alpha-SR2, S5AR 2, SR type 2, Steroid 5-alpha-reductase 2, ...
Reichardt,
Lindström,
Wiklund,
Adami,
B??lter,
Adolfsson,
Gr??nberg,
Hiort,
Schütt,
Bals-Pratsch,
Holterhus,
Marschke,
Struve,
Rossi,
Leveri,
Gritti,
De Silvestri,
Zavaglia,
Sonzogni,
Silvestri,
Civardi,
Mondelli,
Silini,
Söderström,
Wadelius,
Andersson,
Johansson,
Johansson,
Granath,
Rane,
Latil,
Azzouzi,
Cancel,
Guillaume,
Cochan-Priollet,
Berthon,
Cussenot,
Klotsman,
Weinberg,
Davis,
Binnie,
Hartmann,
- Germ-Line Genetic Variation in the Key Androgen-Regulating Genes Androgen Receptor, Cytochrome P450, and Steroid-5-{alpha}-Reductase Type 2 Is Important for Prostate Cancer Development. Lindstr??m, S., Wiklund, F., Adami, H.O., B??lter, K.A., Adolfsson, J., Gr??nberg, H. Cancer Res. (2006)
- Uniparental disomy in steroid 5alpha-reductase 2 deficiency. Chávez, B., Valdez, E., Vilchis, F. J. Clin. Endocrinol. Metab. (2000)
- 5alpha-reductase 2 polymorphisms as risk factors in prostate cancer. Söderström, T., Wadelius, M., Andersson, S.O., Johansson, J.E., Johansson, S., Granath, F., Rane, A. Pharmacogenetics (2002)
- Mutation analysis of five candidate genes in Chinese patients with hypospadias. Wang, Y., Li, Q., Xu, J., Liu, Q., Wang, W., Lin, Y., Ma, F., Chen, T., Li, S., Shen, Y. Eur. J. Hum. Genet. (2004)
- A novel homozygous disruptive mutation in the SRD5A2-gene in a partially virilized patient with 5alpha-reductase deficiency. Hiort, O., Schütt, S.M., Bals-Pratsch, M., Holterhus, P.M., Marschke, C., Struve, D. Int. J. Androl. (2002)
- Steroid 5 alpha-reductase 2 deficiency. Wilson, J.D., Griffin, J.E., Russell, D.W. Endocr. Rev. (1993)
- Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism. Andersson, S., Berman, D.M., Jenkins, E.P., Russell, D.W. Nature (1991)
- Hormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: a nested case-control study among men. Yu, M.W., Yang, Y.C., Yang, S.Y., Cheng, S.W., Liaw, Y.F., Lin, S.M., Chen, C.J. J. Natl. Cancer Inst. (2001)
- Molecular genetics of steroid 5 alpha-reductase 2 deficiency. Thigpen, A.E., Davis, D.L., Milatovich, A., Mendonca, B.B., Imperato-McGinley, J., Griffin, J.E., Francke, U., Wilson, J.D., Russell, D.W. J. Clin. Invest. (1992)
- Identification and characterization of somatic steroid 5alpha-reductase (SRD5A2) mutations in human prostate cancer tissue. Makridakis, N., Akalu, A., Reichardt, J.K. Oncogene (2004)
- Polymorphic markers in the 5alpha-reductase type II gene and the incidence of prostate cancer. Lamharzi, N., Johnson, M.M., Goodman, G., Etzioni, R., Weiss, N.S., Dightman, D.A., Barnett, M., DiTommaso, D., Chen, C. Int. J. Cancer (2003)
- Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2, CYP17, and the AR. Cicek, M.S., Conti, D.V., Curran, A., Neville, P.J., Paris, P.L., Casey, G., Witte, J.S. Prostate (2004)
- Associations between polymorphisms in the steroid 5-alpha reductase type II (SRD5A2) gene and benign prostatic hyperplasia and prostate cancer. Salam, M.T., Ursin, G., Skinner, E.C., Dessissa, T., Reichardt, J.K. Urol. Oncol. (2005)
- Prostate cancer risk and polymorphism in 17 hydroxylase (CYP17) and steroid reductase (SRD5A2). Lunn, R.M., Bell, D.A., Mohler, J.L., Taylor, J.A. Carcinogenesis (1999)
- Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma. Luo, J., Dunn, T.A., Ewing, C.M., Walsh, P.C., Isaacs, W.B. Prostate (2003)
- GEN GEN: the genomic genetic analysis of androgen-metabolic genes and prostate cancer as a paradigm for the dissection of complex phenotypes. Reichardt, J.K. Front. Biosci. (1999)
- Association of polymorphisms within androgen receptor, 5alpha-reductase, and PSA genes with prostate volume, clinical parameters, and endocrine status in elderly men. Schatzl, G., Madersbacher, S., Gsur, A., Preyer, M., Haidinger, G., Haitel, A., Vutuc, C., Micksche, M., Marberger, M. Prostate (2002)
- Clinical, biochemical and morphologic diagnostic markers in an infant male pseudohermaphrodite patient with compound heterozygous mutations (G115D/R246W) in SRD5A2 gene. Fernández-Cancio, M., Rodó, J., Andaluz, P., Martínez de Osaba, M.J., Rodríguez-Hierro, F., Esteban, C., Carrascosa, A., Audí, L. Horm. Res. (2004)
- Identification of missense mutations in the SRD5A2 gene from patients with steroid 5alpha-reductase 2 deficiency. Vilchis, F., Méndez, J.P., Canto, P., Lieberman, E., Chávez, B. Clin. Endocrinol. (Oxf) (2000)
- Somatic mutations at the SRD5A2 locus encoding prostatic steroid 5alpha-reductase during prostate cancer progression. Akalu, A., Dlmajian, D.A., Highshaw, R.A., Nichols, P.W., Reichardt, J.K. J. Urol. (1999)
- New frameshift mutation in the 5alpha-reductase type 2 gene in a Brazilian patient with 5alpha-reductase deficiency. Ferraz, L.F., Mathias Baptista, M.T., Maciel-Guerra, A.T., Júnior, G.G., Hackel, C. Am. J. Med. Genet. (1999)
- Codon 89 polymorphism in the human 5 alpha-reductase gene in primary breast cancer. Scorilas, A., Bharaj, B., Giai, M., Diamandis, E.P. Br. J. Cancer (2001)
- Testosterone enanthate therapy is effective and independent of SRD5A2 and AR gene polymorphisms in boys with micropenis. Ishii, T., Sasaki, G., Hasegawa, T., Sato, S., Matsuo, N., Ogata, T. J. Urol. (2004)
- The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer. Haiman, C.A., Stampfer, M.J., Giovannucci, E., Ma, J., Decalo, N.E., Kantoff, P.W., Hunter, D.J. Cancer Epidemiol. Biomarkers Prev. (2001)
- Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism. Ji, Q., Chang, L., VanDenBerg, D., Stanczyk, F.Z., Stolz, A. Prostate (2003)
- A case-based evaluation of SRD5A1, SRD5A2, AR, and ADRA1A as candidate genes for severity of BPH. Klotsman, M., Weinberg, C.R., Davis, K., Binnie, C.G., Hartmann, K.E. Pharmacogenomics J. (2004)
- Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways. Latil, A.G., Azzouzi, R., Cancel, G.S., Guillaume, E.C., Cochan-Priollet, B., Berthon, P.L., Cussenot, O. Cancer (2001)
- Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients. Rossi, L., Leveri, M., Gritti, C., De Silvestri, A., Zavaglia, C., Sonzogni, L., Silvestri, L., Civardi, E., Mondelli, M.U., Silini, E.M. J. Hepatol. (2003)
- Genetic linkage mapping of the human steroid 5 alpha-reductase type 2 gene (SRD5A2) close to D2S352 on chromosome region 2p23-->p22. Morissette, J., Durocher, F., Leblanc, J.F., Normand, T., Labrie, F., Simard, J. Cytogenet. Cell Genet. (1996)