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Chemical Compound Review

Clobetasone     17-(2-chloroethanoyl)-9- fluoro-17-hydroxy...

Synonyms: AC1LCH2K
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Disease relevance of Clobetasone


High impact information on Clobetasone


Chemical compound and disease context of Clobetasone


Biological context of Clobetasone


Anatomical context of Clobetasone

  • Clobetasone butyrate showed slight, non-significant effects in the epidermis at the highest concentration (200 microliters; 0.01%), but not in the thymus or spleen [15].
  • The effect of the topical corticosteroid clobetasone butyrate on enzyme activity and morphology of duodenal mucosa was studied in 9 patients with coeliac disease and 10 controls using organ culture techniques [16].
  • The biopsy showed marked degeneration of collagen in the dermis with solar elastosis and some smudging of the papillary dermal collagen (Fig. 2). She was treated with clobetasone cream to the affected areas on the hands [17].

Associations of Clobetasone with other chemical compounds


Gene context of Clobetasone

  • Similarly, even under extreme conditions, clobetasone butyrate 0.05% has negligible systemic absorption and has almost no effect on HPA axis function [21].

Analytical, diagnostic and therapeutic context of Clobetasone


  1. Fluticasone propionate 0.05% cream once daily versus clobetasone butyrate 0.05% cream twice daily in children with atopic dermatitis. Wolkerstorfer, A., Strobos, M.A., Glazenburg, E.J., Mulder, P.G., Oranje, A.P. J. Am. Acad. Dermatol. (1998) [Pubmed]
  2. A separation of clinical from epidermal thinning effect in the topical glucocorticoid clobetasone butyrate. Stevanovic, D.V., Wilson, L., Sparkes, C.G. Br. J. Dermatol. (1977) [Pubmed]
  3. Allergic contact dermatitis due to clobetasone butyrate. Murata, T., Tanaka, M., Dekio, I., Tanikawa, A., Nishikawa, T. Contact Derm. (2000) [Pubmed]
  4. Clinical evaluation of clobetasone butyrate eye drops in episcleritis. Lloyd-Jones, D., Tokarewicz, A., Watson, P.G. The British journal of ophthalmology. (1981) [Pubmed]
  5. Double-blind clinical trial of topical steroids in anterior uveitis. Dunne, J.A., Travers, J.P. The British journal of ophthalmology. (1979) [Pubmed]
  6. Use of nonprescription topical steroids: patients' experiences. Rogers, P.J., Wood, S.M., Garrett, E.L., Krykant, S.P., Haddington, N.J., Hayhurst, J., Player, G.R. Br. J. Dermatol. (2005) [Pubmed]
  7. Fluorescence spectroscopy: a rapid, noninvasive method for measurement of skin surface thickness of topical agents. Rhodes, L.E., Diffey, B.L. Br. J. Dermatol. (1997) [Pubmed]
  8. Epidermal cell DNA content and intermediate filaments keratin 10 and vimentin after treatment of psoriasis with calcipotriol cream once daily, twice daily and in combination with clobetasone 17-butyrate cream or betamethasone 17-valerate cream: a comparative flow cytometric study. Glade, C.P., Van Erp, P.E., Van De Kerkhof, P.C. Br. J. Dermatol. (1996) [Pubmed]
  9. Comparative anti-inflammatory efficacy of topical corticosteroids with low glaucoma-inducing potential. Leibowitz, H.M., Ryan, W.J., Kupferman, A. Arch. Ophthalmol. (1992) [Pubmed]
  10. Steroid allergy: report of two cases. Peng, Y.S., Shyur, S.D., Lin, H.Y., Wang, C.Y. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. (2001) [Pubmed]
  11. Alclometasone dipropionate in psoriasis: a clinical study. Aggerwal, A., Maddin, S. J. Int. Med. Res. (1982) [Pubmed]
  12. Use of a combination of an anti-inflammatory steroid, an antibacterial agent and an antifungal in dermatological practice. Pellerano, S. International journal of clinical pharmacology, therapy, and toxicology. (1985) [Pubmed]
  13. Distribution of clobetasone in rabbit eye tissues after topical application. Rink, H., Connors, B., Wegener, A., Umlauf, A., Hockwin, O. Lens and eye toxicity research. (1989) [Pubmed]
  14. Clobetasone butyrate, a new topical corticosteroid: clinical activity and effects on pituitary-adrenal axis function and model of epidermal atrophy. Munro, D.D., Wilson, L. British medical journal. (1975) [Pubmed]
  15. The effects of topical and systemic glucocorticosteroids on DNA synthesis in different tissues of the hairless mouse. Marshall, R.C., Burrows, M., Brookes, L.G., du Vivier, A. Br. J. Dermatol. (1981) [Pubmed]
  16. The effect of the topical steroid clobetasone butyrate on coeliac mucosa maintained in organ culture. Bramble, M.G., Watson, A.J., Record, C.O. Digestion (1981) [Pubmed]
  17. Acrokeratoelastoidosis. Tsai, S., Kageyama, N., Warthan, M., Cockerell, C.J. International journal of dermatology. (2005) [Pubmed]
  18. The effect of clobetasone butyrate and other topical steroids on skin thickness of the domestic pig. Winter, G.D., Wilson, L. Br. J. Dermatol. (1976) [Pubmed]
  19. Concentration of clobetasone butyrate in aqueous humour. Debnath, S.C., Richards, A.B. The British journal of ophthalmology. (1983) [Pubmed]
  20. Comparison of the anti-inflammatory activity and effect on intraocular pressure of fluoromethalone, clobetasone butyrate and betamethasone phosphate eye drops. Kadom, A.H., Forrester, J.V., Williamson, T.H. Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). (1986) [Pubmed]
  21. Eumovate (clobetasone butyrate 0.05%) cream: a review of clinical efficacy and safety. Goustas, P., Cork, M.J., Higson, D. The Journal of dermatological treatment. (2003) [Pubmed]
  22. Equivalence of topical clobetasone and dexamethasone in experimental corneal allograft rejection. Wilhelmus, K.R., Hunter, P.A., Rice, N.S. The British journal of ophthalmology. (1981) [Pubmed]
  23. Clobetasone treatment of allergic conjunctivitis: a comparative double blind study. Cerqueti, P.M., Prosio, P.E., Bosia, S., Buscaglia, S., Ciprandi, G. Allergologia et immunopathologia. (1993) [Pubmed]
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