Disease relevance of Panniculitis

• Systemic lupus erythematosus presenting as panniculitis (lupus profundus) [1].
• Treatment of alpha-1-antitrypsin deficiency, massive edema, and panniculitis with alpha-1 protease inhibitor [2].
• A patient with mediastinal histoplasmosis, alpha 1-antitrypsin deficiency, and panniculitis is presented [3].
• Cirrhosis associated with heterozygous alpha-1-antitrypsin deficiency preceded by a remote history of panniculitis [4].
• Calcifying lupus panniculitis in a patient with subacute cutaneous lupus erythematosus: response to diltiazem and chloroquine [5].

High impact information on Panniculitis

• Aspartame-induced granulomatous panniculitis [6].
• Nitrofurantoin-induced antinuclear antibodies and panniculitis [7].
• Treatment of cytophagic panniculitis with cyclosporin A [8].
• On each occasion the panniculitis responded to increasing the doses of prednisolone [9].
• Panniculitis in familial Mediterranean fever. Case report with histopathologic findings [10].

Chemical compound and disease context of Panniculitis

• Successful treatment of severe cytophagic histiocytic panniculitis with cyclosporine A [11].
• Case number 31: Nodular panniculitis as expression of Munchausen's syndrome (panniculitis artefacta) [12].
• Mycobacterium fortuitum panniculitis in a steroid-dependent asthmatic patient [13].
• One patient, who had more extensive disease, failed to respond to prednisone plus dapsone; infusions of alpha 1-proteinase inhibitor concentrate led to resolution of her panniculitis [14].
• Letter: On the treatment of panniculitis with tetracycline [15].

Biological context of Panniculitis

• Despite reports of cases of systemic nodular panniculitis associated with other alpha-1 antitrypsin deficiency phenotypes, it is still not known if this association is fortuitous rather than causal [16].
• In addition, we review the pathophysiology, epidemiology, and extracutaneous manifestations of AAT disease and propose a diagnostic algorithm for ulcerative panniculitis [17].

Anatomical context of Panniculitis

• This subset of cases shows the histopathologic triad of angiodestruction with associated necrosis, panniculitis, and in some cases atypical lymphoid cells [18].
• Connective tissue diseases, such as systemic lupus erythematosus and dermatomyositis, pancreatic diseases, and alpha(1)-antitrypsin deficiency may also show a mostly lobular panniculitis with characteristic histopathologic features [19].
• Biopsy of these nodules showed a septal panniculitis and foamy macrophages containing PAS-positive, diastase resistant intracytoplasmic material, characteristic of Whipple's disease and similar to that observed in the duodenal biopsy [20].
• Lupus panniculitis is an unusual immunological disease that characteristically affects the subcutaneous fat and occurs in 2% of patients with systemic lupus erythematosus [21].
• Gouty panniculitis, with deposits of urate crystals in the subcutaneous tissue, is a rare dermatologic sequela of gout [22].

Gene context of Panniculitis

• He showed recurrent panniculitis since early infancy, and short stature with delayed skeletal age (3 years less) and low levels of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 [23].
• Lupus erythematosus panniculitis with partial genetic deficiency of C2 and C4 in a child [24].
• Histiocytic markers such as CD68 and lysozyme may be used as reliable tools in order to detect pseudomembranes in panniculitides [25].
• Acquired GLD with GH deficiency (e.g., recurrent panniculitis) may occur as a result of chronic inflammation over the pituitary stalk and pituitary gland [23].
• Six patients are described in whom panniculitis was a major manifestation of systemic lupus erythematosus [1].

Analytical, diagnostic and therapeutic context of Panniculitis

• Alpha-1-antitrypsin deficiency associated with panniculitis treated with plasma exchange therapy [26].
• This report deals with three additional canine cases of sterile panniculitis treated by oral administration of tacrolimus and prednisolone [27].
• These observations suggest that EBV-associated NKCL occurred subsequently in the clinical course of benign panniculitis under the influence of immunosuppression caused by prednisolone treatment and HTLV-1 infection [28].
• Each of the biopsies taken at one and two weeks after treatment with PC and DC showed a normal epithelium and dermis, with a mixed septal and lobular panniculitis [29].
• METHODS: We present a female kidney transplant recipient, with systemic lupus erythematosus on immunossuppresive therapy, who developed panniculitis [30].

References