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Chemical Compound Review

H113_SIGMA     3-amino-2-(4-chlorophenyl)-2- hydroxy...

Synonyms: CHEMBL1256573, A6566_SIGMA, CCG-204174, Lopac0_000079, AC1L1BQU, ...
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Disease relevance of 117354-64-0

  • This action was blocked by 2-OH-saclofen (200 microM) and also by pretreatment of the cultures with pertussis toxin.(ABSTRACT TRUNCATED AT 400 WORDS)[1]
  • Both baclofen-induced hyperpolarization and respiratory depression were antagonised by 2-OH-saclofen, which did not affect respiration-related IPSPs per se [2].
  • Blockade of GABAA receptors by infusion of (-)-bicuculline (25 ng) had no effect on the decrease in body temperature elicited by MSO, but blockade of GABAB receptors by infusion of 2-OH-saclofen (13.3 ng) significantly attenuated MSO-induced hypothermia [3].
  • However, sustained potentiation could not be induced in the presence of the GABAB-receptor antagonists 2-OH-saclofen (400 microM) or CGP35348 (3-amino-propyl-(diethoxymethyl)phosphinic acid, 100 microM), although a subsequent tetanus following washout induced sustained potentiation [4].
  • Ipsilateral intra-NTS microinjection of BMI (10 pmol) or the GABAB-antagonist, 2-OH-saclofen (400 pmol), attenuated the tachycardia elicited from the DMN [5].

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Chemical compound and disease context of 117354-64-0


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Anatomical context of 117354-64-0


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Gene context of 117354-64-0


Analytical, diagnostic and therapeutic context of 117354-64-0


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  24. GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo. Paladini, C.A., Tepper, J.M. Synapse (1999) [Pubmed]
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