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MeSH Review

Vasa Vasorum

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Disease relevance of Vasa Vasorum

  • Medial fibrosis occurred to the same extent as in control grafts, as did the early appearance of platelet factor VIII and fibronectin and the lack of vasa vasorum at 3 days followed by reappearance at 7 days [1].

High impact information on Vasa Vasorum

  • The results support the hypothesis that basic FGF may be contributing to the growth and maintenance of the vasa vasorum and of vascular smooth muscle cells [2].
  • During these interventions, changes in arterial pressure were prevented with propranolol or an arterial reservoir, to minimize indirect effects on vasa vasorum mediated through changes in aortic wall tension [3].
  • 3. 5-Hydroxytryptamine (5-HT), noradrenaline (NA), adrenaline and dopamine caused dose-dependent increases in the vascular resistance of the vasa vasorum [4].
  • During maximal dilatation induced by iv adenosine (4.7 mumol . kg-1 per min) flow delivered via vasa vasorum increased by 100% in both hypertensive and normotensive dogs [5].
  • RESULTS: Oxygen tensions were significantly decreased in the outer artery wall immediately after the creation of the anastomosis and showed a further decrease in oxygen tensions at days 7 and 14, which correlated with the absence of a vasa vasorum [6].

Biological context of Vasa Vasorum


Anatomical context of Vasa Vasorum


Associations of Vasa Vasorum with chemical compounds


Gene context of Vasa Vasorum

  • VEGF administration produced a significant (P < 0.05) increase in vasa vasorum ingrowth and neointima formation [16].
  • In contrast to the pattern described above, the appearance of TGF-beta protein differed from that of mRNA in the vasa vasorum of the ductus wall [8].
  • Thus, the 5-HT1B receptor mRNA detected in tissue extracts of the rat aorta most likely reflects 5-HT1B receptor expression in the arterioles of the vasa vasorum [13].
  • In higher vertebrates SMC of vasa vasorum were both V- and D-positive and showed high enzyme activity [17].

Analytical, diagnostic and therapeutic context of Vasa Vasorum

  • RATIONALE AND OBJECTIVES: We examined the changes in luminal diameter and vasa vasorum after stent dilation of the aorta of nonatherosclerotic rabbits [12].


  1. Histologic, morphometric, and biochemical evolution of vein bypass grafts in a nonhuman primate model. II. Modification of early changes by platelet inhibition with aspirin and dipyridamole. Boerboom, L.E., Olinger, G.N., Liu, T.Z., Rodriguez, E.R., Ferrans, V.J., Kissebah, A.H. J. Thorac. Cardiovasc. Surg. (1990) [Pubmed]
  2. Vascular response to basic fibroblast growth factor when infused onto the normal adventitia or into the injured media of the rat carotid artery. Cuevas, P., Gonzalez, A.M., Carceller, F., Baird, A. Circ. Res. (1991) [Pubmed]
  3. Effects of neural stimuli on blood flow through vasa vasorum in dogs. Heistad, D.D., Marcus, M.L., Martins, J.B. Circ. Res. (1979) [Pubmed]
  4. Effects of aortic pressure and vasoactive agents on the vascular resistance of the vasa vasorum in canine isolated thoracic aorta. Ohhira, A., Ohhashi, T. J. Physiol. (Lond.) (1992) [Pubmed]
  5. Effects of chronic hypertension on vasa vasorum in the thoracic aorta. Marcus, M.L., Heistad, D.D., Armstrong, M.L., Abboud, F.M. Cardiovasc. Res. (1985) [Pubmed]
  6. Transarterial wall oxygen gradients at a prosthetic vascular graft to artery anastomosis in the rabbit. Santilli, S.M., Wernsing, S.E., Lee, E.S. J. Vasc. Surg. (2000) [Pubmed]
  7. In utero remodeling of the fetal lamb ductus arteriosus: the role of antenatal indomethacin and avascular zone thickness on vasa vasorum proliferation, neointima formation, and cell death. Clyman, R.I., Chen, Y.Q., Chemtob, S., Mauray, F., Kohl, T., Varma, D.R., Roman, C. Circulation (2001) [Pubmed]
  8. Transforming growth factor-beta protein and messenger RNA expression is increased in the closing ductus arteriosus. Tannenbaum, J.E., Waleh, N.S., Mauray, F., Gold, L., Perkett, E.A., Clyman, R.I. Pediatr. Res. (1996) [Pubmed]
  9. The role of vasa vasorum in atherosclerosis. Crotty, T.P. Med. Hypotheses (1989) [Pubmed]
  10. CGRP and ET-1 plasma levels in normal subjects. Parlapiano, C., Paoletti, V., Campana, E., Giovanniello, T., Pantone, P., Labbadia, G., Califano, F., Donnarumma, L., Musca, A. European review for medical and pharmacological sciences. (1999) [Pubmed]
  11. The vasa vasorum and angioplasty. Cragg, A.H., Einzig, S., Rysavy, J.A., Castaneda-Zuniga, W.R., Borgwardt, B., Amplatz, K. Radiology. (1983) [Pubmed]
  12. Luminal diameter and vasa vasorum response to stent dilation in the rabbit aorta. Sahler, L.G., Morris, T.W., Owusu, K.N., Gutierrez, O.H. Academic radiology. (1996) [Pubmed]
  13. Lack of sumatriptan-induced aortic contraction or relaxation: 5-HT1B receptor protein detected in endothelium and smooth muscle of vasa vasorum but not aorta. Cohen, M.L., Galbreath, E.J., Schenck, K.W., Li, D., Hoffman, B.J., Bhattacharya, A. Recept. Channels (2002) [Pubmed]
  14. Oxygen tension changes in the outer vascular wall supplied by vasa vasorum following adenosine and epinephrine. Buerk, D.G., Goldstick, T.K. Blood vessels. (1986) [Pubmed]
  15. Routes of drug delivery to the middle segment of the canine inferior vena cava in vivo. Uematsu, T., Tsuru, H., Shigei, T. Archives internationales de pharmacodynamie et de thérapie. (1983) [Pubmed]
  16. VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus. Clyman, R.I., Seidner, S.R., Kajino, H., Roman, C., Koch, C.J., Ferrara, N., Waleh, N., Mauray, F., Chen, Y.Q., Perkett, E.A., Quinn, T. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  17. Intermediate filaments and ATPase activity in the vascular wall of vertebrates. Dikranian, K., Trosheva, M., Petrov, M. Acta Histochem. (1993) [Pubmed]
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