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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Catgut

  • While the chromic catgut was kept integral in all the environments, the PGA and the P910 dissolved in urine infected by Proteus, which was caused by the ammonia resulting from the urea-splitting reaction [1].

Psychiatry related information on Catgut


High impact information on Catgut

  • Plain catgut sutures lost relatively significant amounts of strength at both acidic and alkaline conditions when compared with Dexon and Vicryl sutures; hence, precaution should be taken when they are used in closing tissues in contact with acidic environment like the stomach [4].
  • MATERIALS AND METHODS: Chemical (2.5% formalin), immune (lipopolysaccharide 2 x 104 cfu/ml.) and mechanical (chromic catgut) inflammation was evaluated at various times and compared to control bladders [5].
  • Controlled trial of polyglycolic acid versus catgut and nylon for appendicectomy wound closure [6].
  • The effect of immersion in sterile urine, infected urine and plasma on the breaking strength and stiffness of polydioxanone (PDS), polyglycolic acid (PGA) and chromic catgut was studied [7].
  • To produce chronic inflammation one silk suture and one catgut suture were placed through the bladder wall of 63 mice to receive FANFT and 18 to receive normal diet [8].

Biological context of Catgut

  • Finally, at 6-8 weeks postpartum there was no difference in residual suture (2 of 175 versus 2 of 134; P =.802) or wound breakdowns (4 of 175 versus 3 of 134; P =.959) for fast-absorbing polyglactin 910 and chromic catgut, respectively [9].
  • We studied the influence of soluble factors associated with silk, steel, nylon, polyglactin, polydioxanone and chromic catgut sutures on macrophage adherence, phagocytosis and the production of lysozyme and tumour necrosis factor [10].
  • Total cell number value in Vicryl group was found to be significantly lower than the one in catgut group (P<0.05) [11].

Anatomical context of Catgut


Associations of Catgut with chemical compounds

  • METHODS: Policies of repair with polyglactin 910 or chromic catgut were compared [15].
  • In vivo evaluation of a new polyurethane-coated catgut suture [16].
  • OBJECTIVES: To compare the effects of chromic catgut, polyglactic acid, polydioxanone (PDS), and polytrimethylene carbonate suture on urothelial healing in a rabbit model simulating pyeloplasty [17].
  • Histoacryl-tissue adhesive (B. Braun Melsungen AG W. Germany) was used in place of skin sutures (2/0 chromic catgut, Ethicon Ltd, Edinburgh, Scotland) for episiotomy repair in a group of 20 women [18].
  • This study was devised to disclose any harmful effect of stimulation of the bowel by neostigmine (Prostigmin), alone, or in combination with castor oil in 220 canine anastomoses (60 stapled, 60 two-layer silk and catgut inverted, and 100 one-layer silk everted) performed in enteroenterostomies, ileocolostomies, and colocolostomies [19].

Gene context of Catgut

  • Ten suture materials of 2-0 (chromic catgut, Dexon, Vicryl, PDS, Mersilene, Tycron, Ethibond, Surgilon, Ethilon, and Prolene) were used [20].
  • The findings indicate that the use of chromic catgut still predominates, but that the newer synthetic absorbable materials such as polyglycolic acid and polyglactin 910 are becoming popular for some procedures, including certain steps in abdominal closure and in reconstructive tubal surgery [21].
  • Consecutive patients undergoing abdominal operation--elective and emergency surgery--through a midline abdominal wound were randomized to have the peritoneal layer closed with continuous catgut, or to have this step omitted [22].

Analytical, diagnostic and therapeutic context of Catgut


  1. Effects of the pH and the urine infected by Escherichia coli and Proteus mirabilis on chromic catgut, polyglycolic acid and polyglactin 910: study in vitro. Hering, F.L., Rosenberg, D., Chade, J. Urologia internationalis. (1989) [Pubmed]
  2. Comparison of Maxon suture with Vicryl, chromic catgut, and PDS sutures in fascial closure in rats. Sanz, L.E., Patterson, J.A., Kamath, R., Willett, G., Ahmed, S.W., Butterfield, A.B. Obstetrics and gynecology. (1988) [Pubmed]
  3. The Ipswich childbirth study: one year follow up of alternative methods used in perineal repair. Grant, A., Gordon, B., Mackrodat, C., Fern, E., Truesdale, A., Ayers, S. BJOG : an international journal of obstetrics and gynaecology. (2001) [Pubmed]
  4. An in vitro evaluation of the stability of mechanical properties of surgical suture materials in various pH conditions. Chu, C.C., Moncrief, G. Ann. Surg. (1983) [Pubmed]
  5. Histological and neurotrophic changes triggered by varying models of bladder inflammation. Dupont, M.C., Spitsbergen, J.M., Kim, K.B., Tuttle, J.B., Steers, W.D. J. Urol. (2001) [Pubmed]
  6. Controlled trial of polyglycolic acid versus catgut and nylon for appendicectomy wound closure. Wetter, L.A., Dinneen, M.D., Levitt, M.D., Motson, R.W. The British journal of surgery. (1991) [Pubmed]
  7. In vitro comparison of the properties of polydioxanone, polyglycolic acid and catgut sutures in sterile and infected urine. el-Mahrouky, A., McElhaney, J., Bartone, F.F., King, L. J. Urol. (1987) [Pubmed]
  8. N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced bladder cancer in mice: augmentation by sutures through the bladder wall. Chester, J.F., Gaissert, H.A., Ross, J.S., Malt, R.A., Weitzman, S.A. J. Urol. (1987) [Pubmed]
  9. Randomized comparison of chromic versus fast-absorbing polyglactin 910 for postpartum perineal repair. Greenberg, J.A., Lieberman, E., Cohen, A.P., Ecker, J.L. Obstetrics and gynecology. (2004) [Pubmed]
  10. Influence of soluble suture factors on in vitro macrophage function. Uff, C.R., Scott, A.D., Pockley, A.G., Phillips, R.K. Biomaterials (1995) [Pubmed]
  11. Comparison of four different suture materials in soft tissues of rats. Yaltirik, M., Dedeoglu, K., Bilgic, B., Koray, M., Ersev, H., Issever, H., Dulger, O., Soley, S. Oral diseases. (2003) [Pubmed]
  12. Pharyngocutaneous fistula following laryngectomy. Soylu, L., Kiroglu, M., Aydogan, B., Cetik, F., Kiroglu, F., Akçali, C., Ozşahinoglu, C. Head & neck. (1998) [Pubmed]
  13. A preliminary study on the effect of ultrasound therapy on the healing of surgically severed achilles tendons in five dogs. Saini, N.S., Roy, K.S., Bansal, P.S., Singh, B., Simran, P.S. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. (2002) [Pubmed]
  14. An experimental study of the calcification and absorption of polyglycolic acid and catgut sutures within the urinary tract. Milroy, E. Investigative urology. (1976) [Pubmed]
  15. The Ipswich Childbirth Study: 2. A randomised comparison of polyglactin 910 with chromic catgut for postpartum perineal repair. Mackrodt, C., Gordon, B., Fern, E., Ayers, S., Truesdale, A., Grant, A. British journal of obstetrics and gynaecology. (1998) [Pubmed]
  16. In vivo evaluation of a new polyurethane-coated catgut suture. Bichon, D., Borloz, W., Cassano-Zoppi, A.L. Biomaterials (1984) [Pubmed]
  17. Comparison of effects of suture materials on wound healing in a rabbit pyeloplasty model. Wainstein, M., Anderson, J., Elder, J.S. Urology (1997) [Pubmed]
  18. The use of Histoacryl for episiotomy repair. Adoni, A., Anteby, E. British journal of obstetrics and gynaecology. (1991) [Pubmed]
  19. Studies in intestinal healing VI. Effect of pharmacologically induced peristalsis on fresh intestinal anastomoses in dogs. Brolin, R.E., Ravitch, M.M. Archives of surgery (Chicago, Ill. : 1960) (1980) [Pubmed]
  20. Effects of physical configuration and chemical structure of suture materials on bacterial adhesion. A possible link to wound infection. Chu, C.C., Williams, D.F. Am. J. Surg. (1984) [Pubmed]
  21. Suture materials currently used in obstetric-gynecologic surgery in the United States: a questionnaire survey. Hartko, W.J., Ghanekar, G., Kemmann, E. Obstetrics and gynecology. (1982) [Pubmed]
  22. Is closure of the peritoneal layer necessary in the repair of midline surgical abdominal wounds? Hugh, T.B., Nankivell, C., Meagher, A.P., Li, B. World journal of surgery. (1990) [Pubmed]
  23. Use of Vicryl (polyglactin 910) sutures in general surgical and cardiothoracic procedures. Reul, G.J. Am. J. Surg. (1977) [Pubmed]
  24. The Southmead perineal suture study. A randomized comparison of suture materials and suturing techniques for repair of perineal trauma. Mahomed, K., Grant, A., Ashurst, H., James, D. British journal of obstetrics and gynaecology. (1989) [Pubmed]
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