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Disease relevance of Hevea


High impact information on Hevea

  • Natural rubber, cis-1,4-polyisoprene, is obtained from a colloidal fluid called latex, which represents the cytoplasmic content of the laticifers of the rubber tree (Hevea brasiliensis) [6].
  • The hydroxynitrile lyase from Hevea brasiliensis (HbHNL) uses a catalytic triad consisting of Ser(80)-His(235)-Asp(207) to enhance the basicity of Ser(80)-O gamma for abstracting a proton from the OH group of the substrate cyanohydrin [7].
  • Mechanistic proposals have been put forward in the past for both enzymes; they differed with respect to the role of the active-site lysine residue for which a catalytic function was claimed for the Hevea enzyme but denied for the Manihot enzyme [8].
  • Identification, cloning, and sequence of a major allergen (Hev b 5) from natural rubber latex (Hevea brasiliensis) [2].
  • The tonoplast-associated citrate binding protein (CBP) of Hevea brasiliensis. Photoaffinity labeling, purification, and cloning of the corresponding gene [9].

Chemical compound and disease context of Hevea


Biological context of Hevea


Anatomical context of Hevea

  • In order to identify proteins mediating the transport, two photoreactive analogues (N'-(2-hydroxy-5-azido)-diazo-N-3,5-benzenedicarboxylic acid and 5-azidoisophthalic acid) of malate/citrate were synthesized and found to efficiently inhibit citrate uptake into barley vacuoles (Ki = 18 microM) and Hevea lutoid vesicles (Ki = 27 microM) [9].
  • Several hybridomas were produced against antigens extracted from the latex sap of Hevea brasiliensis [16].
  • Involvement of Hevea latex organelle membrane proteins in the rubber biosynthesis activity and regulatory function [17].

Associations of Hevea with chemical compounds

  • A prenyltransferase purified from the commercial rubber tree, Hevea brasiliensis, that elongates existing cis-polyisoprene rubber molecules also catalyzes the formation of all trans-farnesyl pyrophosphate (t,t-FPP) from dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) [18].
  • A detailed comparison of citrate uptake into the vacuole-like lutoids of rubber tree (Hevea brasiliensis Muell. Arg.) and of malate and citrate transport into barley (Hordeum vulgare L.) vacuoles revealed very similar transport specificities [9].
  • Using degenerate oligonucleotides of the NH2-terminal sequence, a cDNA coding for the CBP protein of Hevea was isolated [9].
  • Hevein, a small protein from the latex of Hevea brasiliensis, has been crystallized by the vapor diffusion method using 2-methyl-2,4-pentanediol and CaCl2 as the precipitant agents [19].
  • The effect of EDTA and Mg(2+) ion on in vitro rubber biosynthesis in fig tree and rubber tree suggested that divalent metal ion present in the latex serum is an important factor in determining the different rubber biosynthetic activities in fig tree and rubber tree [20].

Gene context of Hevea


Analytical, diagnostic and therapeutic context of Hevea


  1. A novel acidic allergen, Hev b 5, in latex. Purification, cloning and characterization. Akasawa, A., Hsieh, L.S., Martin, B.M., Liu, T., Lin, Y. J. Biol. Chem. (1996) [Pubmed]
  2. Identification, cloning, and sequence of a major allergen (Hev b 5) from natural rubber latex (Hevea brasiliensis). Slater, J.E., Vedvick, T., Arthur-Smith, A., Trybul, D.E., Kekwick, R.G. J. Biol. Chem. (1996) [Pubmed]
  3. Hev b 7 is a Hevea brasiliensis protein associated with latex allergy in children with spina bifida. Wagner, B., Buck, D., Hafner, C., Sowka, S., Niggemann, B., Scheiner, O., Breiteneder, H. J. Allergy Clin. Immunol. (2001) [Pubmed]
  4. The hevein domain of the major latex-glove allergen Hev b 6.01 contains dominant T cell reactive sites. de Silva, H.D., Gardner, L.M., Drew, A.C., Beezhold, D.H., Rolland, J.M., O'Hehir, R.E. Clin. Exp. Allergy (2004) [Pubmed]
  5. Identification of a Hevea brasiliensis latex manganese superoxide dismutase (Hev b 10) as a cross-reactive allergen. Wagner, S., Sowka, S., Mayer, C., Crameri, R., Focke, M., Kurup, V.P., Scheiner, O., Breiteneder, H. Int. Arch. Allergy Immunol. (2001) [Pubmed]
  6. Laticifer-specific gene expression in Hevea brasiliensis (rubber tree). Kush, A., Goyvaerts, E., Chye, M.L., Chua, N.H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. Observation of a short, strong hydrogen bond in the active site of hydroxynitrile lyase from Hevea brasiliensis explains a large pKa shift of the catalytic base induced by the reaction intermediate. Stranzl, G.R., Gruber, K., Steinkellner, G., Zangger, K., Schwab, H., Kratky, C. J. Biol. Chem. (2004) [Pubmed]
  8. Reaction mechanism of hydroxynitrile lyases of the alpha/beta-hydrolase superfamily: the three-dimensional structure of the transient enzyme-substrate complex certifies the crucial role of LYS236. Gruber, K., Gartler, G., Krammer, B., Schwab, H., Kratky, C. J. Biol. Chem. (2004) [Pubmed]
  9. The tonoplast-associated citrate binding protein (CBP) of Hevea brasiliensis. Photoaffinity labeling, purification, and cloning of the corresponding gene. Rentsch, D., Görlach, J., Vogt, E., Amrhein, N., Martinoia, E. J. Biol. Chem. (1995) [Pubmed]
  10. Asthma caused by Ficus benjamina latex: evidence of cross-reactivity with fig fruit and papain. Díez-Gómez, M.L., Quirce, S., Aragoneses, E., Cuevas, M. Ann. Allergy Asthma Immunol. (1998) [Pubmed]
  11. Amino acid sequence of rubber elongation factor protein associated with rubber particles in Hevea latex. Dennis, M.S., Henzel, W.J., Bell, J., Kohr, W., Light, D.R. J. Biol. Chem. (1989) [Pubmed]
  12. Inhaled latex allergen (Hev b 1). Poulos, L.M., O'Meara, T.J., Hamilton, R.G., Tovey, E.R. J. Allergy Clin. Immunol. (2002) [Pubmed]
  13. Nucleotide sequence of a cDNA clone encoding the precursor of ribulose-1,5-bisphosphate carboxylase small subunit from Hevea brasiliensis (rubber tree). Chye, M.L., Tan, S.A., Tan, C.T., Kush, A., Chua, N.H. Plant Mol. Biol. (1991) [Pubmed]
  14. beta-1,3-Glucanase is highly-expressed in laticifers of Hevea brasiliensis. Chye, M.L., Cheung, K.Y. Plant Mol. Biol. (1995) [Pubmed]
  15. Enzyme kinetics of hevamine, a chitinase from the rubber tree Hevea brasiliensis. Bokma, E., Barends, T., Terwissch van Scheltingab, A.C., Dijkstr, B.W., Beintema, J.J. FEBS Lett. (2000) [Pubmed]
  16. Characterization of a monoclonal antibody against latex protein associated with latex allergy. Kurup, V.P., Kumar, A., Kelly, K.J., Fink, J.N. J. Allergy Clin. Immunol. (1993) [Pubmed]
  17. Involvement of Hevea latex organelle membrane proteins in the rubber biosynthesis activity and regulatory function. Wititsuwaannakul, D., Rattanapittayaporn, A., Koyama, T., Wititsuwaannakul, R. Macromolecular bioscience. (2004) [Pubmed]
  18. Rubber elongation by farnesyl pyrophosphate synthases involves a novel switch in enzyme stereospecificity. Light, D.R., Lazarus, R.A., Dennis, M.S. J. Biol. Chem. (1989) [Pubmed]
  19. Preliminary x-ray investigation of an orthorhombic crystal of hevein. Rodríguez, A., Tablero, M., Arreguín, B., Hernández, A., Arreguín, R., Soriano-García, M., Tulinsky, A., Park, C.H., Seshadri, T.P. J. Biol. Chem. (1988) [Pubmed]
  20. Identification of natural rubber and characterization of rubber biosynthetic activity in fig tree. Kang, H., Kang, M.Y., Han, K.H. Plant Physiol. (2000) [Pubmed]
  21. Molecular cloning, purification, and IgE-binding of a recombinant class I chitinase from Hevea brasiliensis leaves (rHev b 11.0102). Rihs, H.P., Dumont, B., Rozynek, P., Lundberg, M., Cremer, R., Brüning, T., Raulf-Heimsoth, M. Allergy (2003) [Pubmed]
  22. Characterization of cDNA and genomic clones encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase from Hevea brasiliensis. Chye, M.L., Kush, A., Tan, C.T., Chua, N.H. Plant Mol. Biol. (1991) [Pubmed]
  23. Three genes encode 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hevea brasiliensis: hmg1 and hmg3 are differentially expressed. Chye, M.L., Tan, C.T., Chua, N.H. Plant Mol. Biol. (1992) [Pubmed]
  24. IgE immune response to rubber proteins in adult patients with latex allergy. Alenius, H., Turjanmaa, K., Mäkinen-Kiljunen, S., Reunala, T., Palosuo, T. J. Allergy Clin. Immunol. (1994) [Pubmed]
  25. Chloride-ion stimulation of the tonoplast H+-translocating ATPase from Hevea brasiliensis (rubber tree) latex. A dual mechanism. Marin, B.P., Gidrol, X. Biochem. J. (1985) [Pubmed]
  26. Absence of cross-reactivity of IgE antibodies from subjects allergic to Hevea brasiliensis latex with a new source of natural rubber latex from guayule (Parthenium argentatum). Siler, D.J., Cornish, K., Hamilton, R.G. J. Allergy Clin. Immunol. (1996) [Pubmed]
  27. Isolation and identification of hevein as a major IgE-binding polypeptide in Hevea latex. Chen, Z., Posch, A., Lohaus, C., Raulf-Heimsoth, M., Meyer, H.E., Baur, X. J. Allergy Clin. Immunol. (1997) [Pubmed]
  28. Crystallization of hevamine, an enzyme with lysozyme/chitinase activity from Hevea brasiliensis latex. Rozeboom, H.J., Budiani, A., Beintema, J.J., Dijkstra, B.W. J. Mol. Biol. (1990) [Pubmed]
  29. Molecular cloning of a new cDNA and expression of 3-hydroxy-3-methylglutaryl-CoA synthase gene from Hevea brasiliensis. Sirinupong, N., Suwanmanee, P., Doolittle, R.F., Suvachitanont, W. Planta (2005) [Pubmed]
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