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MeSH Review

Sheep, Domestic

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Disease relevance of Sheep, Domestic


High impact information on Sheep, Domestic

  • A mutation causing muscular hypertrophy, with associated leanness and improved feed efficiency, has been recently identified in domestic sheep (Ovis aries) [2].
  • Domestic sheep have two common alleles at the adult beta-globin locus, beta A and beta B. Here we report the structure of the beta-globin locus of A-haplotype sheep [3].
  • In the mouflon, Soay and some of the domesticated breeds of sheep (Wiltshire, Herdwick and Shetland), the seasonal increase in prolactin was also temporally correlated with the resurgence of growth of the pelage in spring and a conspicuous moult [4].
  • In the mouflon rams, the seasonal changes were very pronounced with a 6-15-fold increase in the plasma concentrations of FSH, inhibin and testosterone from summer to autumn, and a late peak in testicular diameter in October [5].
  • Progesterone and oestrogen concentrations in plasma of Barbary sheep (aoudad, Ammotragus lervia) compared with those of domestic sheep and goats during pregnancy [6].

Biological context of Sheep, Domestic


Anatomical context of Sheep, Domestic


Associations of Sheep, Domestic with chemical compounds

  • Rams of an ancient breed of domestic sheep (Soay) were housed under artificial lighting conditions to study the way in which the secretion of LH and testosterone changes in relation to the mating season [12].
  • No differences in serum progesterone, oestrone, prostaglandin F-2 alpha metabolites or cortisol concentrations could be detected during pregnancy between recipients carrying Dall's sheep embryos, recipients receiving progesterone treatment or domestic ewes carrying domestic sheep pregnancies [13].
  • Within the limits of sampling frequency, the duration of melatonin secretion was similar in both groups during the solstice and equinox periods; however, the amplitude was lower (P < 0.01) in Mouflons than Manchegas during the solstice periods [14].
  • Mean serum glucose concentrations in the markhor, mouflon, and aoudad were 110 +/- 23.2, 111.4 +/- 37.1, and 132.5 +/- 38.5 mg/dl, respectively, and were considered within the normal ranges for these species [15].
  • A survey of the gastro-intestinal nematodes in domestic sheep and goats of the Sahelian zone of Senegal was undertaken [16].

Gene context of Sheep, Domestic

  • The highest CYP3A-dependent testosterone 6beta-hydroxylase activity was found in mouflons and fallow deer [17].
  • The results indicate that ivermectin should be considered as an inducer of several cytochrome P450 isoenzymes, including CYP1A, 2B and 3A subfamilies, in mouflons [18].
  • Cloning and comparison of bighorn sheep CD18 with that of domestic sheep, goats, cattle, humans and mice [19].
  • Transferrin type D was observed in the mouflons, while Tfs D and E were in the desert bighorns [20].
  • Mouflon beta-lactoglobulin is a 162 amino acid long polypeptide chain with two disulphide bridges and one free thiol group [10].

Analytical, diagnostic and therapeutic context of Sheep, Domestic


  1. Albendazole repeated administration induces cytochromes P4501A and accelerates albendazole deactivation in mouflon (Ovis musimon). Velík, J., Szotáková, B., Baliharová, V., Lamka, J., Savlík, M., Wsól, V., Snejdrová, E., Skálová, L. Res. Vet. Sci. (2005) [Pubmed]
  2. Chromosomal localization of the callipyge gene in sheep (Ovis aries) using bovine DNA markers. Cockett, N.E., Jackson, S.P., Shay, T.L., Nielsen, D., Moore, S.S., Steele, M.R., Barendse, W., Green, R.D., Georges, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. A comparison of the beta A-and beta B-globin gene clusters of sheep. Garner, K.J., Lingrel, J.B. J. Mol. Evol. (1989) [Pubmed]
  4. Correlation with changes in horns and pelage, but not reproduction, of seasonal cycles in the secretion of prolactin in rams of wild, feral and domesticated breeds of sheep. Lincoln, G.A. J. Reprod. Fertil. (1990) [Pubmed]
  5. Seasonal cycles in the blood plasma concentration of FSH, inhibin and testosterone, and testicular size in rams of wild, feral and domesticated breeds of sheep. Lincoln, G.A., Lincoln, C.E., McNeilly, A.S. J. Reprod. Fertil. (1990) [Pubmed]
  6. Progesterone and oestrogen concentrations in plasma of Barbary sheep (aoudad, Ammotragus lervia) compared with those of domestic sheep and goats during pregnancy. Hamon, M.H., Heap, R.B. J. Reprod. Fertil. (1990) [Pubmed]
  7. Aromatizing activity of placental microsomal fractions from ewes in late gestation. Mann, M.R., Curet, L.B., Colas, A.E. J. Endocrinol. (1975) [Pubmed]
  8. Influence of age on the relationship between annual changes in horn growth rate and prolactin secretion in the European mouflon (Ovis gmelini musimon). Santiago-Moreno, J., Gómez-Brunet, A., Toledano-Díaz, A., González-Bulnes, A., Picazo, R.A., López-Sebastián, A. Anim. Reprod. Sci. (2005) [Pubmed]
  9. Pharmacokinetics and sedative effects of intramuscular medetomidine in domestic sheep. Kästner, S.B., Wapf, P., Feige, K., Demuth, D., Bettschart- Wolfensberger, R., Akens, M.K., Huhtinen, M. J. Vet. Pharmacol. Ther. (2003) [Pubmed]
  10. The complete amino-acid sequence of dimeric beta-lactoglobulin from mouflon (Ovis ammon musimon) milk. Godovac-Zimmermann, J., Conti, A., Napolitano, L. Biol. Chem. Hoppe-Seyler (1987) [Pubmed]
  11. Stereospecific biotransformation of albendazole in mouflon and rat-isolated hepatocytes. Velík, J., Baliharová, V., Skálová, L., Szotáková, B., Wsól, V., Lamka, J. J. Vet. Pharmacol. Ther. (2003) [Pubmed]
  12. Seasonal variation in the episodic secretion of luteinizing hormone and testosterone in the ram. Lincoln, G.A. J. Endocrinol. (1976) [Pubmed]
  13. Failure to maintain interspecific pregnancy after transfer of Dall's sheep embryos to domestic ewes. Buckrell, B.C., Gartley, C.J., Mehren, K.G., Crawshaw, G.J., Johnson, W.H., Barker, I.K., Balke, J., Coghill, C., Challis, J.R., Goodrowe, K.L. J. Reprod. Fertil. (1990) [Pubmed]
  14. Seasonal changes in ovulatory activity, plasma prolactin, and melatonin concentrations, in mouflon (Ovis gmelini musimon) and Manchega (Ovis aries) ewes. Santiago-Moreno, J., López-Sebastián, A., González-Bulnes, A., Gómez-Brunet, A., Chemineau, P. Reprod. Nutr. Dev. (2000) [Pubmed]
  15. Percentage of glycosylated hemoglobin and serum concentration of glucose in the blood of Japanese macaques and in three exotic ruminant species. Richter, N.A. Am. J. Vet. Res. (1986) [Pubmed]
  16. A survey of seasonal changes in nematode faecal egg count levels of sheep and goats in Senegal. Vercruysse, J. Vet. Parasitol. (1983) [Pubmed]
  17. Inter-species comparisons of hepatic cytochrome P450 enzyme levels in male ruminants. Machala, M., Soucek, P., Neca, J., Ulrich, R., Lamka, J., Szotáková, B., Skálová, L. Arch. Toxicol. (2003) [Pubmed]
  18. Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama). Skálová, L., Szotáková, B., Machala, M., Neca, J., Soucek, P., Havlasová, J., Wsól, V., Krídová, L., Kvasnicková, E., Lamka, J. Chem. Biol. Interact. (2001) [Pubmed]
  19. Cloning and comparison of bighorn sheep CD18 with that of domestic sheep, goats, cattle, humans and mice. Liu, W., Brayton, K.A., Lagerquist, J., Foreyt, W.J., Srikumaran, S. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  20. Blood group comparisons between European mouflon sheep and north American desert bighorn sheep. Bunch, T.D., Nguyen, T.C. J. Hered. (1982) [Pubmed]
  21. One and two dimensional isoelectric focusing of lactate dehydrogenase from the tissues of ovis aries. Beatty, E.M., Doxey, D.L. Comp. Biochem. Physiol., B (1983) [Pubmed]
  22. Comparison of medetomidine and dexmedetomidine as premedication in isoflurane anaesthesia for orthopaedic surgery in domestic sheep. Kästner, S.B., Von Rechenberg, B., Keller, K., Bettschart-Wolfensberger, R. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. (2001) [Pubmed]
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