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Gene Review

TF  -  transferrin

Ovis aries

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Disease relevance of TF

  • Interaction of ruminant transferrins with transferrin receptors in bovine isolates of Pasteurella haemolytica and Haemophilus somnus [1].
  • Rapid alterations in transferrin sialylation during sepsis [2].
  • Production of transferrin receptors by Histophilus ovis: three of five strains require two signals [3].
  • Using the parabolic equation, y = axb, the constants for the relationship between body weight (x) and transferrin turnover (y) were a, 22.845; and b, 0.68 [4].
  • The transferrin system in Herdwick sheep, bred at Compton, was investigated with special reference to the susceptibility of the flock to experimentally produced scrapie [5].

High impact information on TF


Chemical compound and disease context of TF

  • Sepsis is associated with decreased SA content on circulating transferrin and with an increase in blood free SA concentrations [2].

Biological context of TF


Anatomical context of TF

  • Hemoglobin released from lysed erythrocytes can restore the transferrin-inhibited growth of C. albicans [15].
  • 3. With regard to activation-associated lymphocyte markers, iron significantly enhanced expression of the receptor for transferrin as identified by the monoclonal antibody, OKT9 [16].
  • The changes parallel those observed in normal T-cell differentiation and partly reflect alterations in glycosyl transferase activity, altered synthesis of proteins and regulation of cell surface receptors (for transferrin) associated with rapid growth and metabolism [17].
  • Neither cAMP nor transferrin had a significant stimulating effect on blastocyst development of 1/8 blastomeres when mKRB plus serum was used as the medium [18].
  • In conclusion, secretions by Sertoli cells of the paracrine factor involved in the control of testosterone production by Leydig cells and of transferrin are modified by germ cells [19].

Associations of TF with chemical compounds

  • Vesicles containing peptides that comigrate with the transferrin receptor on polyacrylamide gels are released during incubation of sheep reticulocytes, tagged with anti-transferrin-receptor antibodies [6].
  • SCE cultures were established from 20-day-old rats and maintained in SF media supplemented with insulin, transferrin, epidermal growth factor (EGF), and bacitracin [20].
  • When culture was performed in a serum-free medium containing transferrin and ascorbic acid, the number of cells increased only slightly (1.2-fold) over a 4-day period [21].
  • Inclusion of transferrin or retinol in the culture medium increased the production of 5 alpha-reduced metabolites [22].
  • Large-format, two-dimensional polyacrylamide gel electrophoresis of ovine periimplantation uterine luminal fluid proteins: identification of aldose reductase, cytoplasmic actin, and transferrin as conceptus-synthesized proteins [23].

Physical interactions of TF


Other interactions of TF


Analytical, diagnostic and therapeutic context of TF


  1. Interaction of ruminant transferrins with transferrin receptors in bovine isolates of Pasteurella haemolytica and Haemophilus somnus. Yu, R.H., Gray-Owen, S.D., Ogunnariwo, J., Schryvers, A.B. Infect. Immun. (1992) [Pubmed]
  2. Rapid alterations in transferrin sialylation during sepsis. Piagnerelli, M., Boudjeltia, K.Z., Nuyens, V., De Backer, D., Su, F., Wang, Z., Vincent, J.L., Vanhaeverbeek, M. Shock (2005) [Pubmed]
  3. Production of transferrin receptors by Histophilus ovis: three of five strains require two signals. Ekins, A., Niven, D.F. Can. J. Microbiol. (2001) [Pubmed]
  4. Transferrin catabolism in mammalian species of different body sizes. Regoeczi, E., Hatton, M.W. Am. J. Physiol. (1980) [Pubmed]
  5. Transferrin polymorphism in Herdwick sheep. Collis, S.C., Millson, G.C. Animal blood groups and biochemical genetics. (1975) [Pubmed]
  6. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Pan, B.T., Johnstone, R.M. Cell (1983) [Pubmed]
  7. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. Pan, B.T., Teng, K., Wu, C., Adam, M., Johnstone, R.M. J. Cell Biol. (1985) [Pubmed]
  8. Separation and functional studies of the human lymphokine-activated killer cell. Roberts, K., Lotze, M.T., Rosenberg, S.A. Cancer Res. (1987) [Pubmed]
  9. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). Johnstone, R.M., Adam, M., Hammond, J.R., Orr, L., Turbide, C. J. Biol. Chem. (1987) [Pubmed]
  10. In vitro acylation of the transferrin receptor. Adam, M., Rodriguez, A., Turbide, C., Larrick, J., Meighen, E., Johnstone, R.M. J. Biol. Chem. (1984) [Pubmed]
  11. Selective externalization of the transferrin receptor by sheep reticulocytes in vitro. Response to ligands and inhibitors of endocytosis. Pan, B.T., Johnstone, R. J. Biol. Chem. (1984) [Pubmed]
  12. Protein kinase C does not phosphorylate the externalized form of the transferrin receptor. Adam, M.A., Johnstone, R.M. Biochem. J. (1987) [Pubmed]
  13. Loss of the transferrin receptor during the maturation of sheep reticulocytes in vitro. An immunological approach. Pan, B.T., Blostein, R., Johnstone, R.M. Biochem. J. (1983) [Pubmed]
  14. Purification of ovine transferrin and study of the hormonal control of its secretion in enriched cultures of ovine Sertoli cells. Monet-Kuntz, C., Guillou, F., Fontaine, I., Combarnous, Y. J. Reprod. Fertil. (1992) [Pubmed]
  15. Production of a hemolytic factor by Candida albicans. Manns, J.M., Mosser, D.M., Buckley, H.R. Infect. Immun. (1994) [Pubmed]
  16. The immunoregulatory nature of iron. II. Lymphocyte surface marker expression. Bryan, C.F., Leech, S.H., Bozelka, B. J. Leukoc. Biol. (1986) [Pubmed]
  17. Modulation of T leukaemic cell phenotype with phorbol ester. Delia, D., Greaves, M.F., Newman, R.A., Sutherland, D.R., Minowada, J., Kung, P., Goldstein, G. Int. J. Cancer (1982) [Pubmed]
  18. Effects of extracellular matrices and growth factors on the development of isolated porcine blastomeres. Saito, S., Niemann, H. Biol. Reprod. (1991) [Pubmed]
  19. Evidence for germ cell control of Sertoli cell function in three models of germ cell depletion in adult rat. Boujrad, N., Hochereau-de Reviers, M.T., Carreau, S. Biol. Reprod. (1995) [Pubmed]
  20. Inhibin production by primary Sertoli cell-enriched cultures: regulation by follicle-stimulating hormone, androgens, and epidermal growth factor. Morris, P.L., Vale, W.W., Cappel, S., Bardin, C.W. Endocrinology (1988) [Pubmed]
  21. In vitro effect of insulin and insulin-like growth factor-I on cell multiplication and adrenocorticotropin responsiveness of fetal adrenal cells. Naaman, E., Chatelain, P., Saez, J.M., Durand, P. Biol. Reprod. (1989) [Pubmed]
  22. Influence of rete testis fluid on the metabolism of testosterone by cultured principal cells isolated from the proximal or distal caput of the rat epididymis. Brown, D.V., Amann, R.P., Wagley, L.M. Biol. Reprod. (1983) [Pubmed]
  23. Large-format, two-dimensional polyacrylamide gel electrophoresis of ovine periimplantation uterine luminal fluid proteins: identification of aldose reductase, cytoplasmic actin, and transferrin as conceptus-synthesized proteins. Lee, R.S., Wheeler, T.T., Peterson, A.J. Biol. Reprod. (1998) [Pubmed]
  24. Synthesis of lactoferrin and transport of transferrin in the lactating mammary gland of sheep. Sanchez, L., Lujan, L., Oria, R., Castillo, H., Perez, D., Ena, J.M., Calvo, M. J. Dairy Sci. (1992) [Pubmed]
  25. Iodide induces transforming growth factor beta 1 (TGF-beta 1) mRNA in sheep thyroid cells. Yuasa, R., Eggo, M.C., Meinkoth, J., Dillmann, W.H., Burrow, G.N. Thyroid (1992) [Pubmed]
  26. The distribution of plasma proteins during early embryonic development in the sheep. Reynolds, M.L., Møllgård, K., Saunders, N.R. Anat. Embryol. (1983) [Pubmed]
  27. On-line capillary isoelectric focusing-mass spectrometry for quantitative analysis of peptides and proteins. Kuroda, Y., Yukinaga, H., Kitano, M., Noguchi, T., Nemati, M., Shibukawa, A., Nakagawa, T., Matsuzaki, K. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  28. Biosynthesis of the transferrin receptor in rabbit reticulocytes. Cox, T.M., O'Donnell, M.W., Aisen, P., London, I.M. J. Clin. Invest. (1985) [Pubmed]
  29. Identification of fur and fldA homologs and a Pasteurella multocida tbpA homolog in Histophilus ovis and effects of iron availability on their transcription. Ekins, A., Niven, D.F. J. Bacteriol. (2002) [Pubmed]
  30. Effects of interleukin-2 on the pulmonary microvasculature in anesthetized sheep. Lei, D., Jerome, E.H., Douguet, D., Jesmok, G.J., Schuster, D.P., Johnson, C.W., Staub, N.C. J. Appl. Physiol. (1994) [Pubmed]
  31. Hormonal regulation of insulin-like growth factor (IGF)-binding proteins secreted by isolated sheep thyroid epithelial cells: relationship with iodine organification. Wang, J.F., Becks, G.P., Hanada, E., Buckingham, K.D., Phillips, I.D., Hill, D.J. J. Endocrinol. (1991) [Pubmed]
  32. Transferrin variants in sheep: separation and characterization by polyacrylamide gel electrophoresis and isoelectric focusing. Erhardt, G. Anim. Genet. (1986) [Pubmed]
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