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Gene Review

Mas1  -  MAS1 oncogene

Mus musculus

Synonyms: Mas, Mas-1, Mgra, Proto-oncogene Mas
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Disease relevance of Mas1


High impact information on Mas1

  • Here we describe a family of approximately 50 GPCRs related to Mas1, called mrgs, a subset of which is expressed in specific subpopulations of sensory neurons that detect painful stimuli [4].
  • We investigated the allele-specific expression pattern of the Mas gene on the basis of its proximity to the known imprinted gene for the insulin growth factor type II receptor (Igf2r) [5].
  • The Mas protooncogene on mouse chromosome 17 encodes a mitogenic G-protein-coupled cell surface receptor [5].
  • Our results demonstrate parental imprinting of Mas and suggest that the maternally inherited allele is transcriptionally repressed in a developmental and tissue-specific manner [5].
  • By 13.5 days of gestation the paternal allele-specific expression of Mas was restricted to heart, tongue and visceral yolk sac, whereas all other tissues exhibited relaxation of the parental imprint [5].

Biological context of Mas1


Anatomical context of Mas1


Associations of Mas1 with chemical compounds


Other interactions of Mas1

  • The results demonstrate a map position for Mas in the close vicinity of Igf2r, which encodes another membrane receptor known to undergo genomic imprinting [6].
  • Taken together, these observations suggest that Mas transformation is mediated in part by activation of Rac-dependent signaling pathways [8].
  • Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1 and AT2 receptors in the mouse heart [13].
  • Therefore, we determined if Mas signaling and transformation are mediated through activation of a specific Rho family protein [8].
  • Mas and the AT1 receptor formed a constitutive hetero-oligomeric complex that was unaffected by the presence of agonists or antagonists of the 2 receptors [14].

Analytical, diagnostic and therapeutic context of Mas1

  • In this study we investigated the role of Mas on cardiac function during ischemia/reperfusion in isolated perfused mouse heart [2].
  • Isolated heart of Mas KO and WT treated with A-779 presented an increase in the perfusion pressure in the baseline period [2].
  • Echocardiography revealed that hearts of Mas-deficient mice showed a significantly decreased fractional shortening, posterior wall thickness in systole and left ventricle end-diastolic dimension, and a higher left ventricle end-systolic dimension [15].


  1. Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis. Rousseau, C., Sirakova, T.D., Dubey, V.S., Bordat, Y., Kolattukudy, P.E., Gicquel, B., Jackson, M. Microbiology (Reading, Engl.) (2003) [Pubmed]
  2. Effects of genetic deletion of angiotensin-(1-7) receptor Mas on cardiac function during ischemia/reperfusion in the isolated perfused mouse heart. Castro, C.H., Santos, R.A., Ferreira, A.J., Bader, M., Alenina, N., Almeida, A.P. Life Sci. (2006) [Pubmed]
  3. Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo. Chand, P., Bantia, S., Kotian, P.L., El-Kattan, Y., Lin, T.H., Babu, Y.S. Bioorg. Med. Chem. (2005) [Pubmed]
  4. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong, X., Han, S., Zylka, M.J., Simon, M.I., Anderson, D.J. Cell (2001) [Pubmed]
  5. Parental imprinting of the Mas protooncogene in mouse. Villar, A.J., Pedersen, R.A. Nat. Genet. (1994) [Pubmed]
  6. Localization of the Mas proto-oncogene to a densely marked region of mouse chromosome 17 associated with genomic imprinting. Cebra-Thomas, J.A., Tsai, J.Y., Pilder, S.H., Copeland, N.G., Jenkins, N.A., Silver, L.M. Genomics (1992) [Pubmed]
  7. Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice. von Bohlen und Halbach, O., Walther, T., Bader, M., Albrecht, D. Regul. Pept. (2001) [Pubmed]
  8. Mas oncogene signaling and transformation require the small GTP-binding protein Rac. Zohn, I.E., Symons, M., Chrzanowska-Wodnicka, M., Westwick, J.K., Der, C.J. Mol. Cell. Biol. (1998) [Pubmed]
  9. Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene. Walther, T., Balschun, D., Voigt, J.P., Fink, H., Zuschratter, W., Birchmeier, C., Ganten, D., Bader, M. J. Biol. Chem. (1998) [Pubmed]
  10. Imprinting of the murine MAS protooncogene is restricted to its antisense RNA. Alenina, N., Bader, M., Walther, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  11. Interaction between Mas and the angiotensin AT1 receptor in the amygdala. Von Bohlen und Halbach, O., Walther, T., Bader, M., Albrecht, D. J. Neurophysiol. (2000) [Pubmed]
  12. The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice. Lemos, V.S., Silva, D.M., Walther, T., Alenina, N., Bader, M., Santos, R.A. J. Cardiovasc. Pharmacol. (2005) [Pubmed]
  13. Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1 and AT2 receptors in the mouse heart. Castro, C.H., Santos, R.A., Ferreira, A.J., Bader, M., Alenina, N., Almeida, A.P. Hypertension (2005) [Pubmed]
  14. G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor. Kostenis, E., Milligan, G., Christopoulos, A., Sanchez-Ferrer, C.F., Heringer-Walther, S., Sexton, P.M., Gembardt, F., Kellett, E., Martini, L., Vanderheyden, P., Schultheiss, H.P., Walther, T. Circulation (2005) [Pubmed]
  15. Impairment of in vitro and in vivo heart function in angiotensin-(1-7) receptor MAS knockout mice. Santos, R.A., Castro, C.H., Gava, E., Pinheiro, S.V., Almeida, A.P., Paula, R.D., Cruz, J.S., Ramos, A.S., Rosa, K.T., Irigoyen, M.C., Bader, M., Alenina, N., Kitten, G.T., Ferreira, A.J. Hypertension (2006) [Pubmed]
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