Disease relevance of Hemispherectomy

• Functional hemispherectomy for treatment of epilepsy associated with hemiplegia: rationale, indications, results, and comparison with callosotomy [1].
• Pathological study of a subtotal hemispherectomy specimen revealed widespread cerebral vasculitis with immunofluorescence staining for IgG, IgM, IgA, C3, and Clq, and ultrastructural evidence of vascular injury in addition to severe cortical atrophy with marked neuronal loss [2].
• Sensorimotor functions were examined in a patient with left-sided infantile hemiparesis who underwent hemispherectomy (HS) on the right side at age 18 for intractable epilepsy [3].
• With improved surgical techniques and diagnostic testing, some medical centers with a special interest in epilepsy are again using hemispherectomy as a treatment for uncontrolled seizures associated with Rasmussen's encephalitis, as well as other etiologies [4].
• The findings, compared with those obtained from choroid plexuses of controls subjected to hemispherectomy for epilepsy, highlight the intense metabolic activity of the papilloma and the relevance of this to the communicating hydrocephalus that is frequently associated with it [5].

Psychiatry related information on Hemispherectomy

• Severe aphasia, adult left hemispherectomy, Gilles de la Tourette syndrome (GTS), and other neurological disorders have in common an increased use of swearwords [6].

High impact information on Hemispherectomy

• Bipolar illness after right hemispherectomy. A response to lithium carbonate and carbamazepine [7].
• In 3 children who had undergone cerebral hemispherectomy (hemidecortication) between the ages of 1 year 5 months and 4 years for the alleviation of intractable epilepsy, cerebral glucose utilization was studied serially with positron emission tomography [8].
• Three to 7 months after hemispherectomy, glucose utilization in the caudate nuclei on the side of hemispherectomy had decreased to below preoperative values, presumably due to total deprivation of ipsilateral cortical input [8].
• This study reports on the clinical course and outcomes of 33 children who underwent hemispherectomy at Great Ormond Street Hospital, London, between 1991 and 1997 [9].
• The efficacy of PAI in our patient supports the autoimmune hypothesis of RE and suggests its application to avoid, or at least delay, functional hemispherectomy in selected cases [10].

Biological context of Hemispherectomy

• BACKGROUND: Transcranial magnetic stimulation (TMS) was utilized to study 7 patients who had undergone hemispherectomy for control of longstanding intractable epilepsy to assess cortical motor reorganization and MEP (motor evoked potentials) ipsilateral to the remaining hemisphere [11].

Anatomical context of Hemispherectomy

• The postoperative results of the Cartagena program were compared with those reported at the Second International Palm Desert Conference 1992, which revealed a similar rate of postoperative seizure control in temporal lobe epilepsy, slightly inferior results with hemispherectomy, and slightly better results with anterior callosotomy [12].
• A detailed study was made of the pathology of specimens removed by hemispherectomy for the treatment of intractable epilepsy in children with unilateral middle cerebral artery stroke [13].
• It is suggested that both of these measurements must be taken into account when assessing morphological effects upon the neocortex either in human pathology (i.e. hemispherectomy, intractable epilepsy) or in animal models [14].

Associations of Hemispherectomy with chemical compounds

• Bilateral ballistic movements occurring as a late complication of hemispherectomy and responding to sulpiride [15].
• The same corticosterone (B) profile was observed after hemispherectomy as in intact pigeons, exhibiting episodic increase including several successive peaks after stress application [16].
• Technetium-99m HmPAO brain SPECT and outcome of hemispherectomy for intractable seizures [17].
• Because medical treatment that included phenobarbital, phenytoin, carbamazepine, oxcarbazepine, benzodiazepines, corticosteroids, gamma-globulin, and a ketogenic diet was ineffective, he underwent a right hemispherectomy [18].

Gene context of Hemispherectomy

• Performance on the ITPA following cerebral commissurotomy and hemispherectomy [19].
• The techniques of neuronal disconnection included multiple subpial resection (MST), corpus callosotomy. and functional hemispherectomy by disconnection [20].
• Unilateral auditory language comprehension on the Token Test following cerebral commissurotomy and hemispherectomy [21].
• To examine further the relationships between brain function and dreaming, we studied REM sleep dream recall and content in four patients having undergone right functional or anatomical hemispherectomy and eight matched control subjects [22].
• Recently, we introduced the concept of peri-insular hemispherotomy, a functional hemispherectomy with minimal brain removal (9, 21) [23].

Analytical, diagnostic and therapeutic context of Hemispherectomy

• We evaluated motor cortical excitability of the unaffected hemisphere in three patients with intractable epilepsy who underwent hemispherectomy, using transcranial magnetic stimulation (TMS) and PET [24].
• Use of recombinant human erythropoietin to avoid blood transfusion in a Jehovah's Witness requiring hemispherectomy. Case report [25].

References