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MeSH Review

Morinda

 
 
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Disease relevance of Morinda

  • An immunomodulatory polysaccharide-rich substance (Noni-ppt) from the fruit juice of Morinda citrifolia has been found to possess both prophylactic and therapeutic potentials against the immunomodulator sensitive Sarcoma 180 tumour system [1].
  • The fruit juice of Morinda citrifolia (noni) contains a polysaccharide-rich substance (noni-ppt) with antitumour activity in the Lewis lung (LLC) peritoneal carcinomatosis model [2].
 

High impact information on Morinda

 

Biological context of Morinda

 

Associations of Morinda with chemical compounds

  • Evaluation of the anti-diabetic property of Morinda lucida leaves in streptozotocin-diabetic rats [10].
  • The hypoglycaemic and anti-hyperglycaemic activities of a methanol extract of Morinda lucida Benth [10].
  • Two known glycosides and a novel trisaccharide fatty acid ester were isolated from the n-butanol-soluble fraction of the fruits of Morinda citrifolia (noni) [11].
  • These results suggest that the leaves of Morinda lucida have a strong glucose lowering property when administered to streptozotocin-treated rats [10].
  • One new iridoid glycoside and five known flavonol glycosides have been isolated from the leaves of Morinda citrifolia [12].
 

Gene context of Morinda

  • Anthraquinones production, hydrogen peroxide level and antioxidant vitamins in Morinda elliptica cell suspension cultures from intermediary and production medium strategies [13].
  • An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni) [14].
  • The results suggest that prevention of carcinogen-DNA adduct formation and the antioxidant activity of TNJ may contribute to the cancer preventive effect of Morinda citrifolia [15].
  • New unusual iridoids from the leaves of noni (Morinda citrifolia L.) show inhibitory effect on ultraviolet B-induced transcriptional activator protein-1 (AP-1) activity [16].
  • These results suggest that anthraquinone derived from Noni extract is a good candidate for use as a new anti-wrinkle agent due to its strong induction of biosynthetic activity of extracellular matrix components [17].
 

Analytical, diagnostic and therapeutic context of Morinda

References

  1. Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice. Furusawa, E., Hirazumi, A., Story, S., Jensen, J. Phytotherapy research : PTR. (2003) [Pubmed]
  2. An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity. Hirazumi, A., Furusawa, E. Phytotherapy research : PTR. (1999) [Pubmed]
  3. A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L. Sang, S., He, K., Liu, G., Zhu, N., Cheng, X., Wang, M., Zheng, Q., Dong, Z., Ghai, G., Rosen, R.T., Ho, C.T. Org. Lett. (2001) [Pubmed]
  4. Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. Hiwasa, T., Arase, Y., Chen, Z., Kita, K., Umezawa, K., Ito, H., Suzuki, N. FEBS Lett. (1999) [Pubmed]
  5. The genetic basis of larval resistance to a host plant toxin in Drosophila sechellia. Jones, C.D. Genet. Res. (2001) [Pubmed]
  6. Complement-modulating properties of a kaempferol 7-O-rhamnosylsophoroside from the leaves of Morinda morindoides. Cimanga, K., de Bruyne, T., Van Poel, B., Ma, Y., Claeys, M., Pieters, L., Kambu, K., Tona, L., Bakana, P., Vanden Berghe, D., Vlietinck, A.J. Planta Med. (1997) [Pubmed]
  7. Anthraquinone production by cell suspension cultures of Morinda citrifolia. Zenk, M.H., el-Shagi, H., Schulte, U. Planta Med. (1975) [Pubmed]
  8. Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia. Hiramatsu, T., Imoto, M., Koyano, T., Umezawa, K. Cancer Lett. (1993) [Pubmed]
  9. Inhibition of the oligosaccharides extracted from Morinda officinalis, a Chinese traditional herbal medicine, on the corticosterone induced apoptosis in PC12 cells. Li, Y.F., Gong, Z.H., Yang, M., Zhao, Y.M., Luo, Z.P. Life Sci. (2003) [Pubmed]
  10. Evaluation of the anti-diabetic property of Morinda lucida leaves in streptozotocin-diabetic rats. Olajide, O.A., Awe, S.O., Makinde, J.M., Morebise, O. J. Pharm. Pharmacol. (1999) [Pubmed]
  11. Novel trisaccharide fatty acid ester identified from the fruits of Morinda citrifolia (Noni). Wang, M., Kikuzaki, H., Csiszar, K., Boyd, C.D., Maunakea, A., Fong, S.F., Ghai, G., Rosen, R.T., Nakatani, N., Ho, C.T. J. Agric. Food Chem. (1999) [Pubmed]
  12. Flavonol glycosides and novel iridoid glycoside from the leaves of Morinda citrifolia. Sang, S., Cheng, X., Zhu, N., Stark, R.E., Badmaev, V., Ghai, G., Rosen, R.T., Ho, C.T. J. Agric. Food Chem. (2001) [Pubmed]
  13. Anthraquinones production, hydrogen peroxide level and antioxidant vitamins in Morinda elliptica cell suspension cultures from intermediary and production medium strategies. Chong, T.M., Abdullah, M.A., Fadzillah, N.M., Lai, O.M., Lajis, N.H. Plant Cell Rep. (2004) [Pubmed]
  14. An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni). Pawlus, A.D., Su, B.N., Keller, W.J., Kinghorn, A.D. J. Nat. Prod. (2005) [Pubmed]
  15. Cancer preventive effect of Morinda citrifolia (Noni). Wang, M.Y., Su, C. Ann. N. Y. Acad. Sci. (2001) [Pubmed]
  16. New unusual iridoids from the leaves of noni (Morinda citrifolia L.) show inhibitory effect on ultraviolet B-induced transcriptional activator protein-1 (AP-1) activity. Sang, S., Liu, G., He, K., Zhu, N., Dong, Z., Zheng, Q., Rosen, R.T., Ho, C.T. Bioorg. Med. Chem. (2003) [Pubmed]
  17. Induction of extracellular matrix synthesis in normal human fibroblasts by anthraquinone isolated from Morinda citrifolia (Noni) fruit. Kim, S.W., Jo, B.K., Jeong, J.H., Choi, S.U., Hwang, Y.I. Journal of medicinal food. (2005) [Pubmed]
  18. Regulation of anthraquinone biosynthesis in cell cultures of Morinda citrifolia. Stalman, M., Koskamp, A.M., Luderer, R., Vernooy, J.H., Wind, J.C., Wullems, G.J., Croes, A.F. J. Plant Physiol. (2003) [Pubmed]
  19. Screening of Morinda lucida leaf extract for antimalarial action on Plasmodium berghei berghei in mice. Makinde, J.M., Obih, P.O. African journal of medicine and medical sciences. (1985) [Pubmed]
 
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