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MeSH Review

Kluyvera

 
 
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Disease relevance of Kluyvera

 

High impact information on Kluyvera

  • Chromosome-encoded Ambler class A beta-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum beta-lactamases [5].
  • Kluyvera ascorbata produces a beta-lactamase that results in an atypical susceptibility pattern, including low-level resistance to penicillins, cephalothin, and cefuroxime, but this resistance is reversed by clavulanate [6].
  • Characterization of a chromosomally encoded extended-spectrum class A beta-lactamase from Kluyvera cryocrescens [2].
  • Changing the substrate specificity of penicillin G acylase from Kluyvera citrophila through selective pressure [7].
  • Inactivation of penicillin acylase from Kluyvera citrophila by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline: a case of time-dependent non-covalent enzyme inhibition [8].
 

Chemical compound and disease context of Kluyvera

  • Penicillin acylase (PA) from Kluyvera citrophila was inhibited by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), a specific carboxy-group-reactive reagent [8].
  • Chemical modification of serine at the active site of penicillin acylase from Kluyvera citrophila [9].
  • Antimicrobial susceptibility studies of the clinically significant and non-clinically significant Kluyvera isolates showed susceptibility patterns similar to those reported in the medical literature, namely trends of resistance to ampicillin and first- and second-generation cephalosporins [10].
  • Of the 4 non-clinically significant isolates in our study, 1 was resistant to ciprofloxacin, a finding reported in only 1 other isolate of Kluyvera in the medical literature [10].
  • Strains of Kluyvera share the properties of most members of the family Enterobacteriaceae: they are gram-negative rods, motile with peritrichous flagella, catalase positive, and oxidase negative; they grow on MacConkey agar, ferment D-glucose with the production of acid and gas, and are susceptible to many antibiotics [11].
 

Biological context of Kluyvera

  • In contrast with the general thought that penicillin G acylases (PGAs) were only able to hydrolyse amides or esters of higly hydrophobic acids, we have demonstrated that the PGA from Kluyvera citrophila catalysed the hydrolysis of 4-nitrophenyl esters of acetic, propionic, butyric and valeric acids [12].
  • The nucleotide sequence of the 5'-terminal region of the pac gene encoding the penicillin G acylase from Kluyvera citrophila ATCC 21285 has been determined [13].
 

Gene context of Kluyvera

  • We found upstream of some bla(CTX-M) genes, a 266-bp sequence 100% identical to the sequence upstream of the Kluyvera ascorbata beta-lactamase gene, suggesting that this chromosomal enzyme is the progenitor of the CTX-M-2/5 cluster [14].
  • Further studies on RpoS in enterobacteria: identification of rpoS in Enterobacter cloacae and Kluyvera cryocrescens [15].

References

  1. Identification of TEM-10 beta-lactamase in a Kluyvera sp. and other Enterobacteriaceae at a Portuguese hospital. Duarte, A., Faria, N., Conceição, T., Correia, M., Lito, L.M., Cristino, J.M., Salgado, M.J., Tenreiro, R. Antimicrob. Agents Chemother. (2002) [Pubmed]
  2. Characterization of a chromosomally encoded extended-spectrum class A beta-lactamase from Kluyvera cryocrescens. Decousser, J.W., Poirel, L., Nordmann, P. Antimicrob. Agents Chemother. (2001) [Pubmed]
  3. Evolution of aromatic amino acid biosynthesis and application to the fine-tuned phylogenetic positioning of enteric bacteria. Ahmad, S., Weisburg, W.G., Jensen, R.A. J. Bacteriol. (1990) [Pubmed]
  4. First strains of the genus Kluyvera in Czechoslovakia. Aldová, E., Hausner, O., Svihálková, A., Láznicková, K., Sobotková, J., Smolka, J., Horácková, O. Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. (1985) [Pubmed]
  5. Chromosome-encoded Ambler class A beta-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum beta-lactamases. Poirel, L., Kämpfer, P., Nordmann, P. Antimicrob. Agents Chemother. (2002) [Pubmed]
  6. Beta-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types. Humeniuk, C., Arlet, G., Gautier, V., Grimont, P., Labia, R., Philippon, A. Antimicrob. Agents Chemother. (2002) [Pubmed]
  7. Changing the substrate specificity of penicillin G acylase from Kluyvera citrophila through selective pressure. Roa, A., Garcia, J.L., Salto, F., Cortes, E. Biochem. J. (1994) [Pubmed]
  8. Inactivation of penicillin acylase from Kluyvera citrophila by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline: a case of time-dependent non-covalent enzyme inhibition. Martín, J., Mancheño, J.M., Arche, R. Biochem. J. (1993) [Pubmed]
  9. Chemical modification of serine at the active site of penicillin acylase from Kluyvera citrophila. Martín, J., Slade, A., Aitken, A., Arche, R., Virden, R. Biochem. J. (1991) [Pubmed]
  10. Clinically significant Kluyvera infections: a report of seven cases. Carter, J.E., Evans, T.N. Am. J. Clin. Pathol. (2005) [Pubmed]
  11. Kluyvera, a new (redefined) genus in the family Enterobacteriaceae: identification of Kluyvera ascorbata sp. nov. and Kluyvera cryocrescens sp. nov. in clinical specimens. Farmer, J.J., Fanning, G.R., Huntley-Carter, G.P., Holmes, B., Hickman, F.W., Richard, C., Brenner, D.J. J. Clin. Microbiol. (1981) [Pubmed]
  12. New insights on the specificity of penicillin acylase. Roa, A., Castillón, M.P., Goble, M.L., Virden, R., García, J.L. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  13. Identification of the pac promoter from Kluyvera citrophila. Roa, A., García, J.L. FEMS Microbiol. Lett. (1997) [Pubmed]
  14. Diversity of CTX-M beta-lactamases and their promoter regions from Enterobacteriaceae isolated in three Parisian hospitals. Saladin, M., Cao, V.T., Lambert, T., Donay, J.L., Herrmann, J.L., Ould-Hocine, Z., Verdet, C., Delisle, F., Philippon, A., Arlet, G. FEMS Microbiol. Lett. (2002) [Pubmed]
  15. Further studies on RpoS in enterobacteria: identification of rpoS in Enterobacter cloacae and Kluyvera cryocrescens. Martínez-García, E., Tormo, A., Navarro-Llorens, J.M. Arch. Microbiol. (2001) [Pubmed]
 
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