Disease relevance of Australasia

• Cryptococcosis in Australasia and the treatment of cryptococcal and other fungal infections with liposomal amphotericin B [1].
• Susceptibility of human influenza viruses from Australasia and South East Asia to the neuraminidase inhibitors zanamivir and oseltamivir [2].
• All reported cases of anaphylaxis to gallamine have occurred in women, and all the confirmed cases in Australasia [3].
• Germline CDKN2A mutations have been observed in approximately 20 percent of familial melanoma kindreds from North America, Europe and Australasia [4].

High impact information on Australasia

• Four thromboplastin reagents were tested by 18 laboratories in Europe, North-America, and Australasia, according to a detailed protocol [5].
• The Royal College of Pathologists of Australasia QA program has conducted external QA testing of factor V Leiden G1691 A, prothrombin G20210A, and MTHFR C677T gene mutations for the past 5 years, including 133 DNA samples in 10 multilaboratory surveys [6].
• Cyclosporin monitoring in Australasia: 2002 update of consensus guidelines [7].
• We estimate that the combined incidence of ALD and its variants in Australasia is at least 1.6 per 100,000 [8].
• Diltiazem is widely prescribed in Australasia as a cyclosporine-sparing agent [9].

Biological context of Australasia

• Nucleotide sequence variation in a region of the mitochondrial cytochrome oxidase subunit I (COI) gene (456 bp) was examined for 26 onychophorans representing 15 genera of the family Peripatopsidae from Australasia [10].
• Comparative bioavailability study of theophylline tablets marketed in Australasia [11].
• For each of the neuraminidase types, IC50 values for viruses from Australasia and South East Asia were found to be comparable [2].

Associations of Australasia with chemical compounds

• INTERVENTION(S): Human menopausal gonadotropin, hCG and Lucrin (Abbott Australasia, Kurnell, NSW, Australia) were given by injection [12].
• A College of Tropical Medicine for Australasia [13].
• Fatalities associated with the use of gamma-hydroxybutyrate and its analogues in Australasia [14].
• Gamma-hydroxybutyric acid (GHB) and its precursors, 1,4-butanediol (1,4-BD) and gamma-butyrolactone (GBL), are recreational drugs widely abused in the US, Europe and Australasia [15].
• A total of 126 influenza B isolates isolated between 1998 and 2002 from Australasia and the Asia-Pacific region were tested for their sensitivity to the neuraminidase (NA) inhibitor drugs zanamivir and oseltamivir carboxylate using a fluorescence-based enzyme assay [16].

Gene context of Australasia

• The distribution of genetic variants at the PGM1 and PGM2 loci in South and East Asia, the Western Pacific and Australasia has been surveyed on the basis of published and unpublished material comprising samples from some 33,000 persons [17].
• The only tests performed with any regularity in Australasia are for thiopurine methyltransferase and pseudocholinesterase, and CYP2D6 phenotyping in one centre for patients on perhexiline [18].
• Human red cell carbonic anhydrase variants in Australasia [19].
• From extensive sampling over a long latitudinal transect in Australasia we here document Adh and inversion clines which are virtually identical to those originally obtained in different Australian populations four years earlier [20].
• Prostate cancer screening in Australasia [21].

Analytical, diagnostic and therapeutic context of Australasia

• Data from noncomparative multicenter trials of cefoperazone sodium in 17 countries throughout Australasia, Europe, and Latin America were analyzed [22].

References