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Chemical Compound Review

AC1L32UY     N-[(1S)-1-[[(1S)-1-[[1- [[(1S)-1-[[(1R)-1...

Synonyms: UNII-37JNS02E7V, 53714-56-0 (Parent)
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Disease relevance of

 

High impact information on

 

Chemical compound and disease context of

 

Biological context of

 

Anatomical context of

 

Associations of with other chemical compounds

 

Gene context of

  • Northern blot hybridization was used to determine the GnRH-R mRNA concentration several times after an injection of TAP-144-SR, a slow releasing GnRHa [17].
  • These results indicate that the paradoxical effects were more extensive upon TAP-144-SR treatment, suggesting that maintaining constant serum TAP-144 levels results in more extensive desensitization of the pituitary and testes [14].
  • METHODS: Adult male rats were castrated by either a single injection of gonadotropin-releasing hormone analogue (Leuplin, 1.0 mg/kg, subcutaneously) or bilateral orchiectomy [18].
 

Analytical, diagnostic and therapeutic context of

References

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  2. Cellular proliferation, estrogen receptor, progesterone receptor, and bcl-2 expression in GnRH agonist-treated uterine leiomyomas. Vu, K., Greenspan, D.L., Wu, T.C., Zacur, H.A., Kurman, R.J. Hum. Pathol. (1998) [Pubmed]
  3. Low-grade endometrial stromal sarcoma preoperative treatment with Depo-Lupron and Megace. Scribner, D.R., Walker, J.L. Gynecol. Oncol. (1998) [Pubmed]
  4. Protective effect of leuprolide acetate on 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis in rats. Inada, K., Tominaga, T., Toi, M., Yamamoto, Y., Abe, M., Yamashita, J., Ogawa, M. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (1996) [Pubmed]
  5. Effects of TAP-144-SR, a sustained-release formulation of a potent GnRH agonist, on experimental endometriosis in the rat. Sudo, K., Shiota, K., Masaki, T., Fujita, T. Endocrinol. Jpn. (1991) [Pubmed]
  6. In situ localization of messenger ribonucleic acid for an oviduct-specific glycoprotein during various hormonal conditions in the golden hamster. Komiya, H., Onuma, T., Hiroi, M., Araki, Y. Biol. Reprod. (1996) [Pubmed]
  7. Evaluation of an implant that delivers leuprolide for 1 year for the palliative treatment of prostate cancer. Fowler, J.E., Flanagan, M., Gleason, D.M., Klimberg, I.W., Gottesman, J.E., Sharifi, R. Urology (2000) [Pubmed]
  8. Can we decrease breakthrough bleeding in patients with endometriosis on norethindrone acetate? Muneyyirci-Delale, O., Jalou, S., Rahman, M., Nacharaju, V. International journal of fertility and women's medicine. (2003) [Pubmed]
  9. Antiproliferative effect of leuprorelin acetate, alone or combined with tamoxifen or medroxyprogesterone acetate, on human breast cancer cell lines. Sica, G., Iacopino, F., Marini, L., Robustelli della Cuna, G. Clinical therapeutics. (1992) [Pubmed]
  10. Pregnancy terminating effect of a highly active LH-RH agonist by vaginal application in rats. Yamazaki, I. Endocrinol. Jpn. (1982) [Pubmed]
  11. Sleep, breathing, and menopause: the effect of fluctuating estrogen and progesterone on sleep and breathing in women. D'Ambrosio, C., Stachenfeld, N.S., Pisani, M., Mohsenin, V. Gender medicine : official journal of the Partnership for Gender-Specific Medicine at Columbia University. (2005) [Pubmed]
  12. Does a gonadotropin-releasing hormone analogue prevent cisplatin-induced spermatogenic impairment? An experimental study in the mouse. Nonomura, M., Okada, K., Hida, S., Yoshida, O. Urol. Res. (1991) [Pubmed]
  13. Enhanced and reversed growth in vitro of a pregnancy-dependent mouse mammary tumor (TPDMT-4) by a gonadotropin-releasing hormone agonist analog. Matsuzawa, A., Yamamoto, T. European journal of cancer & clinical oncology. (1982) [Pubmed]
  14. Endocrinological studies on TAP-144-SR, a sustained-release formulation of a potent GnRH agonist (D-Leu6-[des-Gly10-NH2]-GnRH ethylamide), in male rats. Sudo, K., Masaki, T., Shiota, K., Kawase, M., Fujita, T. Endocrinol. Jpn. (1990) [Pubmed]
  15. Leuprolide acetate given by a subcutaneous extended-release injection: less of a pain? Cox, M.C., Scripture, C.D., Figg, W.D. Expert review of anticancer therapy. (2005) [Pubmed]
  16. Luteinizing hormone-releasing hormone agonists in the treatment of men with prostate cancer: timing, alternatives, and the 1-year implant. Marks, L.S. Urology (2003) [Pubmed]
  17. Continuous stimulation of gonadotropin-releasing hormone (GnRH) receptors by GnRH agonist decreases pituitary GnRH receptor messenger ribonucleic acid concentration in immature female rats. Sakakibara, H., Taga, M., Ikeda, M., Kurogi, K., Minaguchi, H. Endocr. J. (1996) [Pubmed]
  18. Prevention by 17beta-estradiol and progesterone of calcitonin gene-related peptide-induced elevation of skin temperature in castrated male rats. Yuzurihara, M., Ikarashi, Y., Noguchi, M., Kase, Y., Takeda, S., Aburada, M. Urology (2004) [Pubmed]
  19. Serum concentration patterns of an LHRH agonist, gonadotrophins and sex steroids after subcutaneous, vaginal, rectal and nasal administration of the agonist to pregnant rats. Yamazaki, I. J. Reprod. Fertil. (1984) [Pubmed]
  20. A radioimmunoassay for a highly active luteinizing hormone-releasing hormone analogue and relation between the serum level of the analogue and that of gonadotropin. Yamazaki, I., Okada, H. Endocrinol. Jpn. (1980) [Pubmed]
  21. Managing advanced prostate cancer with Viadur (leuprolide acetate implant). Moul, J.W., Civitelli, K. Urologic nursing : official journal of the American Urological Association Allied. (2001) [Pubmed]
 
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