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Chemical Compound Review

Pinacyanol     1-ethyl-2-[(E,3Z)-3-(1- ethylquinolin-2...

Synonyms: Pinacyanole, Carbocyanine, Sensitol Red, CHEBI:52218, LS-142353, ...
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Disease relevance of NCI60_004390


High impact information on NCI60_004390


Chemical compound and disease context of NCI60_004390

  • The ganglion cell dendrites of the rat retina were investigated by means of the strongly fluorescent, non-polar carbocyanine dye 1,1-dioctadecyl-3,3,3',3'-tetramethyl-indocarbodyanine perchlorate (diI or diI-C18-3 or D282) which was taken up by retinofugal axons and transported in the retrograde direction [11].
  • We describe here the application of a carbocyanine dye, 3,3'-dipropylthiodicarbocyanine iodide [DiS-C3-(5)], to monitor the transmembrane potential changes induced by a variation of the K+ concentration for the cells of Escherichia (E.) coli and photosynthetic bacterium Rhodospirillum (R.) rubrum [12].
  • In this study, the lipopolysaccharide-dependent formation of a unique dye absorption spectra of the cationic carbocyanine dye, 1-ethyl-2-[3-(1-ethylnaphtho[1,2d]-thiazolin-2-ylidene)-2-methylpropenyl] naphtho[1,2d]-thiazolium bromide, was used to detect bacteriuria caused by gram negative organisms in a hospitalized population [13].

Biological context of NCI60_004390


Anatomical context of NCI60_004390

  • Complement-dependent swelling and lysis of erythrocytes (a) were limited by the presence of an outwardly directed K+ electrochemical gradient and (b) were enhanced by carbocyanine, a specific inhibitor of the Ca2+-activated K+ transport pathway, and by absence of Ca2+ in the external medium [19].
  • Evidence from labeling growing retinal axons with the carbocyanine dye Dil in mouse embryos indicates that the two subpopulations diverge at a zone along the midline of the optic chiasm [20].
  • The long carbon chain carbocyanine dyes we use are lipid-soluble and so become incorporated into the plasma membrane [21].
  • To distinguish between regeneration by cut neurites and outgrowth by developing uncut neurites, fibers in the ventral fasciculus were prelabeled with carbocyanine dyes and subsequently injured [22].
  • The nonneutralizing anti-c-kit receptor monoclonal antibody 104D2 was directly conjugated to fluorescein isothiocyanate (FITC) or to the carbocyanine dye Cy3 and used to label cytokine-responsive human hematopoietic cell lines [14].

Associations of NCI60_004390 with other chemical compounds

  • Two carbocyanine dyes, 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate and 4-(4-dihexadecylaminostyryl)-N-methylpyridinium iodide, were placed, respectively, into the left and right retinas to identify the course of uncrossed and crossed retinal axons through the optic chiasm and tract [23].
  • The S-phase marker bromodeoxyuridine was used as a surrogate of drug effect and administered 2 hours before tumor excision, whereas vessel position and perfusion were assessed via staining for CD31 and intravenous injection of carbocyanine, respectively [24].
  • Motoneurons from E14 rat embryos have been retrogradely labeled with the carbocyanine derivative dil and purified 12-fold by centrifugation on a density gradient made of Nycodenz, as assessed by the increase in CAT activity per cell and in the percentage of dil-labeled cells [25].
  • For these experiments, a noncompetitive anti-IL1 RI monoclonal antibody, M5, was labeled separately with a donor probe, fluorescein isothiocyanate, or with an acceptor carbocyanine probe, Cy3 [26].
  • No movement of a carbocyanine probe or of octadecyl rhodamine B chloride from labelled to unlabelled cells occurred in the absence of PEG or with cells treated with concanavalin A, protamine or spermine [27].

Gene context of NCI60_004390


Analytical, diagnostic and therapeutic context of NCI60_004390


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  28. Role of Emx2 in the development of the reciprocal connectivity between cortex and thalamus. López-Bendito, G., Chan, C.H., Mallamaci, A., Parnavelas, J., Molnár, Z. J. Comp. Neurol. (2002) [Pubmed]
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