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Gene Review

S100A7  -  S100 calcium binding protein A7

Homo sapiens

Synonyms: PSOR1, Protein S100-A7, Psoriasin, S100 calcium-binding protein A7, S100A7C, ...
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Disease relevance of S100A7


High impact information on S100A7

  • Psoriasin was induced in keratinocytes in vitro and in vivo by E. coli, indicating that its focal expression in skin may derive from local microbial induction [6].
  • Zn(2+)-saturated psoriasin showed diminished antimicrobial activity, suggesting that Zn(2+) sequestration could be a possible antimicrobial mechanism [6].
  • Finally, we show that psoriasin expression is induced by the topoisomerase IIalpha poison, etoposide, in the absence of functional BRCA1 and increased psoriasin expression enhances cellular sensitivity to this chemotherapeutic agent [7].
  • Furthermore, the Jab1-binding domain is also necessary for the enhanced tumorigenicity conferred by S100A7 expression in murine xenograft tumors in vivo [8].
  • BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene [7].

Chemical compound and disease context of S100A7

  • A recent report by Schröder and colleagues suggests that psoriasin, purified from human stratum corneum extracts, selectively kills Escherichia coli by sequestering Zn(2+) ions essential for bacterial growth, indicative of an important role in innate immune defense against microbial infection [9].
  • Here we have used the psoriasin cDNA to express recombinant human (rh) psoriasin in Escherichia coli as a fusion protein containing a hexa His tag and a factor Xa cleavage site in the NH2-terminus [10].
  • Topical all-trans retinoic acid (RA) induces an early, coordinated increase in RA-inducible skin-specific gene/psoriasin and cellular RA-binding protein II mRNA levels which precedes skin erythema [11].

Biological context of S100A7


Anatomical context of S100A7


Associations of S100A7 with chemical compounds


Physical interactions of S100A7


Regulatory relationships of S100A7

  • Furthermore, we demonstrate that overexpression of a dominant negative IKKbeta also inhibits the induction of psoriasin suggesting that the NFkappaB pathway is involved in the induction of this protein [26].
  • Correlating with this, high psoriasin expression in human IBC is associated with increased angiogenesis and worse clinical outcome, and psoriasin mRNA levels are coordinately regulated with VEGF and other genes related to hypoxia and mitochondrial reactive oxygen species (ROS) [27].
  • RanBPM mRNA is also frequently expressed in invasive breast carcinomas (n = 64) and a higher psoriasin/RanBPM ratio is associated with both ER negative (p < 0.0001) and PR negative status (p < 0.001), and inflammatory cell infiltrates (p < 0.0001) within the tumor [24].

Other interactions of S100A7

  • S100A7 and S100A11 are present in the basal and spinous layers in normal epidermis [28].
  • We used PCR to amplify an indel within intron 1 of the S100A7a and S100A7c genes that gave the same two expected product sizes using 40 human DNA samples and 1 chimpanzee sample, therefore confirming the presence of the region 1 and 3 duplication in these species [12].
  • Using S100A10 as new bait, a specific interaction with S100A7 was detectable [29].
  • We conclude that the S100A7-Jab1 pathway acts to enhance survival under conditions of cellular stress, such as anoikis, which may promote progression of breast cancer [8].
  • These data indicate that formation of the E-FABP-S100A7 complex and its FA-binding function might be regulated at least by bivalent cations [18].

Analytical, diagnostic and therapeutic context of S100A7


  1. Psoriasin interacts with Jab1 and influences breast cancer progression. Emberley, E.D., Niu, Y., Leygue, E., Tomes, L., Gietz, R.D., Murphy, L.C., Watson, P.H. Cancer Res. (2003) [Pubmed]
  2. Comparative expression of the psoriasin (S100A7) and S100C genes in breast carcinoma and co-localization to human chromosome 1q21-q22. Moog-Lutz, C., Bouillet, P., Régnier, C.H., Tomasetto, C., Mattei, M.G., Chenard, M.P., Anglard, P., Rio, M.C., Basset, P. Int. J. Cancer (1995) [Pubmed]
  3. Expression patterns of S100A7 (psoriasin) and S100A9 (calgranulin-B) in keratinocyte differentiation. Martinsson, H., Yhr, M., Enerbäck, C. Exp. Dermatol. (2005) [Pubmed]
  4. Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin. Madsen, P., Rasmussen, H.H., Leffers, H., Honoré, B., Dejgaard, K., Olsen, E., Kiil, J., Walbum, E., Andersen, A.H., Basse, B. J. Invest. Dermatol. (1991) [Pubmed]
  5. Amino acid sequence analysis of human S100A7 (psoriasin) by tandem mass spectrometry. Bürgisser, D.M., Siegenthaler, G., Kuster, T., Hellman, U., Hunziker, P., Birchler, N., Heizmann, C.W. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  6. Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Gläser, R., Harder, J., Lange, H., Bartels, J., Christophers, E., Schröder, J.M. Nat. Immunol. (2005) [Pubmed]
  7. BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene. Kennedy, R.D., Gorski, J.J., Quinn, J.E., Stewart, G.E., James, C.R., Moore, S., Mulligan, K., Emberley, E.D., Lioe, T.F., Morrison, P.J., Mullan, P.B., Reid, G., Johnston, P.G., Watson, P.H., Harkin, D.P. Cancer Res. (2005) [Pubmed]
  8. The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer. Emberley, E.D., Niu, Y., Curtis, L., Troup, S., Mandal, S.K., Myers, J.N., Gibson, S.B., Murphy, L.C., Watson, P.H. Cancer Res. (2005) [Pubmed]
  9. Total chemical synthesis of human psoriasin by native chemical ligation. Li, X., de Leeuw, E., Lu, W. Biochemistry (2005) [Pubmed]
  10. Expression and divalent cation binding properties of the novel chemotactic inflammatory protein psoriasin. Vorum, H., Madsen, P., Rasmussen, H.H., Etzerodt, M., Svendsen, I., Celis, J.E., Honoré, B. Electrophoresis (1996) [Pubmed]
  11. Topical all-trans retinoic acid (RA) induces an early, coordinated increase in RA-inducible skin-specific gene/psoriasin and cellular RA-binding protein II mRNA levels which precedes skin erythema. Zouboulis, C.C., Voorhees, J.J., Orfanos, C.E., Tavakkol, A. Arch. Dermatol. Res. (1996) [Pubmed]
  12. Genomic and phylogenetic analysis of the S100A7 (Psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21. Kulski, J.K., Lim, C.P., Dunn, D.S., Bellgard, M. J. Mol. Evol. (2003) [Pubmed]
  13. Cluster analysis of S100 gene expression and genes correlating to psoriasin (S100A7) expression at different stages of breast cancer development. Carlsson, H., Petersson, S., Enerbäck, C. Int. J. Oncol. (2005) [Pubmed]
  14. Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family. Wolf, R., Mirmohammadsadegh, A., Walz, M., Lysa, B., Tartler, U., Remus, R., Hengge, U., Michel, G., Ruzicka, T. FASEB J. (2003) [Pubmed]
  15. S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes. Ruse, M., Broome, A.M., Eckert, R.L. J. Invest. Dermatol. (2003) [Pubmed]
  16. Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales. Hagens, G., Roulin, K., Hotz, R., Saurat, J.H., Hellman, U., Siegenthaler, G. Mol. Cell. Biochem. (1999) [Pubmed]
  17. Refined mapping of the psoriasin gene S100A7 to chromosome 1cen-q21. Børglum, A.D., Flint, T., Madsen, P., Celis, J.E., Kruse, T.A. Hum. Genet. (1995) [Pubmed]
  18. Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes. Hagens, G., Masouyé, I., Augsburger, E., Hotz, R., Saurat, J.H., Siegenthaler, G. Biochem. J. (1999) [Pubmed]
  19. EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing. Brodersen, D.E., Etzerodt, M., Madsen, P., Celis, J.E., Thøgersen, H.C., Nyborg, J., Kjeldgaard, M. Structure (1998) [Pubmed]
  20. cDNA cloning and protein analysis of a bovine dermal allergen with homology to psoriasin. Rautiainen, J., Rytkönen, M., Parkkinen, S., Pentikäinen, J., Linnala-Kankkunen, A., Virtanen, T., Pelkonen, J., Mäntyjärvi, R. J. Invest. Dermatol. (1995) [Pubmed]
  21. Towards a comprehensive database of proteins from the urine of patients with bladder cancer. Rasmussen, H.H., Orntoft, T.F., Wolf, H., Celis, J.E. J. Urol. (1996) [Pubmed]
  22. Immunohistochemical and molecular characterization of cultured keratinocytes after dispase-mediated detachment from the growth substratum. Schaefer, B.M., Wallich, R., Schmolke, K., Fink, W., Bechtel, M., Reinartz, J., Kramer, M.D. Exp. Dermatol. (2000) [Pubmed]
  23. Urinary excretion of epidermal-type fatty acid-binding protein and S100A7 protein in patients with cutaneous melanoma. Brouard, M.C., Saurat, J.H., Ghanem, G., Siegenthaler, G. Melanoma Res. (2002) [Pubmed]
  24. RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer. Emberley, E.D., Gietz, R.D., Campbell, J.D., HayGlass, K.T., Murphy, L.C., Watson, P.H. BMC Cancer (2002) [Pubmed]
  25. A retinoic acid-inducible skin-specific gene (RIS-1/psoriasin): molecular cloning and analysis of gene expression in human skin in vivo and cultured skin cells in vitro. Tavakkol, A., Zouboulis, C.C., Duell, E.A., Voorhees, J.J. Mol. Biol. Rep. (1994) [Pubmed]
  26. Psoriasin (S100A7) and calgranulin-B (S100A9) induction is dependent on reactive oxygen species and is downregulated by Bcl-2 and antioxidants. Carlsson, H., Yhr, M., Petersson, S., Collins, N., Polyak, K., Enerbäck, C. Cancer Biol. Ther. (2005) [Pubmed]
  27. A putative role for psoriasin in breast tumor progression. Krop, I., März, A., Carlsson, H., Li, X., Bloushtain-Qimron, N., Hu, M., Gelman, R., Sabel, M.S., Schnitt, S., Ramaswamy, S., Kleer, C.G., Enerbäck, C., Polyak, K. Cancer Res. (2005) [Pubmed]
  28. S100 protein subcellular localization during epidermal differentiation and psoriasis. Broome, A.M., Ryan, D., Eckert, R.L. J. Histochem. Cytochem. (2003) [Pubmed]
  29. Detection and identification of protein interactions of S100 proteins by ProteinChip technology. Lehmann, R., Melle, C., Escher, N., von Eggeling, F. J. Proteome Res. (2005) [Pubmed]
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