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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Neurology

  • By employing the classical methods of neurology, brain regions associated with symptomatic (pathological) laughter have been determined and catalogued under other diagnostic signs and symptoms of such conditions as epilepsy, strokes and circumspect brain lesions [1].
  • The long-term and within-patient consistency of the efficacy and tolerability of subcutaneous and oral sumatriptan in migraine was studied by retrospective survey of 2 years with mailed self-administered questionnaires in our neurology outpatient clinic [2].
  • He dreamed of constructing a great physiologic institute to study fundamental problems in neurology, including epilepsy, paralysis, muscular atrophy, nerve injuries, and a wide variety of other problems [3].
  • Practice parameter: the care of the patient with amyotrophic lateral sclerosis (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology: ALS Practice Parameters Task Force [4].
  • The diagnostic sensitivities of 5 published CIDP criteria were as follows: the Ad Hoc Subcommittee of the American Academy of Neurology AIDS Task Force (40%), Saperstein et al (47%), Nicolas et al (53%), Hughes et al for the Inflammatory Neuropathy Cause and Treatment Group (60%), and Thaisetthawatkul et al (70%) [5].

Psychiatry related information on Neurology

  • SETTING: Dept. of Neurology, Sleep Disorders Center PATIENTS: Nine patients with moderate to severe RLS (age 38.1 to 64.3 years, mean 54.1 years) who had experienced insufficient benefit under levodopa therapy and/or in part developed daytime augmentation participated [6].
  • DESIGN: National survey of all specialists certified in Neurology or Geriatric Medicine. RESULTS: Of responding physicians (78%) prescribed antithrombotic therapy for patients with vascular dementia [7].
  • Seventy-five families of children with intractable epilepsy but without a severe learning disability (mean age 7 years 1 month, SD 2 years 6 months; range 2 to 12 years) who attended a regional paediatric neurology service, were surveyed [8].
  • All patients were treated at the Clinic of Neurology, Faculty Hospital, Olomouc, Czech Republic. GGT plasma level values and anamnestic data concerning alcohol consumption were also analyzed. chi(2) tests were applied when assessing statistical significance [9].
  • This finding is in contrast to the Nosology of Disorders of Higher Cerebral Function proposed by the Child Neurology Society which views hyperlexia as a variant of the language disorder subtype of dyslexia [10].

High impact information on Neurology


Chemical compound and disease context of Neurology

  • Chronic exposure to manganese causes Parkinson's disease (PD)-like clinical symptoms (Neurotoxicology 5 (1984) 13; Arch. Neurol. 46 (1989) 1104; Neurology 56 (2001) 4) [16].
  • Sixty-five children with seizure disorders, who had been treated with multiple anticonvulsants but were poorly controlled, were selected from the Montreal Children's Hospital Convulsive Disorder Clinic and Neurology Service and were treated with sodium valproate (valproate) [17].
  • Evidence was defined as class I, II, or III, and practice parameter recommendations were made using the framework devised by the American Academy of Neurology. Class I and III evidence support a standard of practice recommendation for the use of vigabatrin in the treatment of infantile spasms in children with tuberous sclerosis [18].
  • Individuals suffering from multiple sclerosis or polyneuropathies were selected from a pool of patients who were under treatment at the Department of Neurology, The Central Hospital of Kuopio, Finland. 27 individuals were identified who had received more than 1.5 g prednisone over a 1-4 year period [19].
  • A factory survey on dose-response relationship in toluene toxicity was conducted in 1985-1989 in four cities in China. The examination items consisted of personal diffusive sampling for TWA exposure measurement, questionnaires on subjective symptoms, hematology and serum biochemistry, and clinical examination including simple neurology tests [20].

Biological context of Neurology

  • A computer search for adult patients with a diagnosis of PM/DM (ICD codes 710.3, 710.4, 517.8) who attended the main rheumatology and neurology centre during this period was also carried out [21].
  • Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology [22].
  • Interferon (IFN) beta-1b has been shown to alter the course of multiple sclerosis and to inhibit MHC class II expression, but its effect on antigen presentation has not been examined in a functional assay (Neurology 43 (1993) 655-661) [23].
  • Admissions by major service were: Medicine, 64 per cent; Surgery, 14 per cent; Neurology, 10 per cent; Orthopedics, 7 per cent; and other, 5 per cent [24].
  • Faculty members from the Departments of Pharmacology, Pathology, Internal Medicine, Psychiatry, and Neurology were major participants in the CNS block, and faculty with primary expertise in radiology, epidemiology, and immunology also participated [25].

Anatomical context of Neurology


Associations of Neurology with chemical compounds

  • Using a two-dimensional gel analysis, we have recently identified Hsc70 as an ethanol-responsive gene (Miles, M.F. (1989) Neurology 39, (Suppl. 1), 425) [31].
  • Whereas sensitivities to heat and to the irritant substance capsaicin have recently been linked via the properties of the vanilloid receptor type 1 receptor ion channel, sensitivity to noxious mechanical stimuli such as the pinpricks used in clinical neurology seems to be unrelated [32].
  • To define the acute course of patients treated with heparin for progressive stroke, we examined the charts of 69 such patients identified through the Cornell Neurology Database from October 1979 to June 1985 [33].
  • We present a region template and a protocol for transforming that template to define anatomical volumes of interest (VOIs) in the human brain without operator intervention, based on software contained in the SPM99 package (Statistical Parametric Mapping, Wellcome Department of Cognitive Neurology, London, UK) [34].
  • BACKGROUND: A 1987 study documented that neurologists and neurology house officers were using excessive amounts of heparin and warfarin [35].

Gene context of Neurology

  • The present results support our previous hypothesis proposed for normal rats that a heterophilic molecular interaction between L1 and neurocan is involved in determining the thalamocortical pathway within the neocortical anlage [T. Fukuda et al. (1997) Journal of Comparative Neurology, 382, 141-152] [36].
  • However, recent guidelines from the American Academy of Neurology suggest that a COMT inhibitor be added to levodopa-dopamine agonist therapy in patients with advanced disease [37].
  • Apolipoprotein E in neurology [38].
  • Our data thus highlight specific and divergent roles of exogenous MT-III vs. the MT-I&II isoforms that are consistent with those attributed to the endogenous proteins, and confirm the suitability of recombinant synthesis for future therapeutic use that may become relevant to clinical neurology [39].
  • While the majority of non-ADHD youth visits were conducted by primary care physicians, one third of ADHD youth visits were managed by psychiatry and neurology specialists [40].

Analytical, diagnostic and therapeutic context of Neurology


  1. Neural correlates of laughter and humour. Wild, B., Rodden, F.A., Grodd, W., Ruch, W. Brain (2003) [Pubmed]
  2. Sumatriptan in clinical practice: a 2-year review of 453 migraine patients. Visser, W.H., de Vriend, R.H., Jaspers, M.W., Ferrari, M.D. Neurology (1996) [Pubmed]
  3. Charles Edouard Brown-Séquard: professor of physiology and pathology of the nervous system at Harvard Medical School. Tyler, H.R., Tyler, K.L. Neurology (1984) [Pubmed]
  4. Practice parameter: the care of the patient with amyotrophic lateral sclerosis (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology: ALS Practice Parameters Task Force. Miller, R.G., Rosenberg, J.A., Gelinas, D.F., Mitsumoto, H., Newman, D., Sufit, R., Borasio, G.D., Bradley, W.G., Bromberg, M.B., Brooks, B.R., Kasarskis, E.J., Munsat, T.L., Oppenheimer, E.A. Neurology (1999) [Pubmed]
  5. Comparison of electrodiagnostic abnormalities and criteria in a cohort of patients with chronic inflammatory demyelinating polyneuropathy. Magda, P., Latov, N., Brannagan, T.H., Weimer, L.H., Chin, R.L., Sander, H.W. Arch. Neurol. (2003) [Pubmed]
  6. Treatment of idiopathic restless legs syndrome (RLS) with the D2-agonist cabergoline--an open clinical trial. Stiasny, K., Röbbecke, J., Schüler, P., Oertel, W.H. Sleep. (2000) [Pubmed]
  7. Subcortical vascular dementia: survey of treatment patterns and research considerations. Molnar, F.J., Man-Son-Hing, M., St John, P., Brymer, C., Rockwood, K., Hachinski, V. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1998) [Pubmed]
  8. Adjustment in children with intractable epilepsy: importance of seizure duration and family factors. McCusker, C.G., Kennedy, P.J., Anderson, J., Hicks, E.M., Hanrahan, D. Developmental medicine and child neurology. (2002) [Pubmed]
  9. The role of chronic alcohol intake in patients with spontaneous intracranial hemorrhage: a carbohydrate-deficient transferrin study. Herzig, R., Urbánek, K., Vlachová, I., Krupka, B., Gabrys, M., Mares, J., Schneiderka, P. Cerebrovasc. Dis. (2003) [Pubmed]
  10. Hyperlexia: a variant of aphasia or dyslexia. Cohen, M., Campbell, R., Gelardo, M. Pediatric neurology. (1987) [Pubmed]
  11. Current concepts in neurology. Partial epilepsy. Schomer, D.L. N. Engl. J. Med. (1983) [Pubmed]
  12. Overutilization of cultures of CSF for mycobacteria. Crowson, T.W., Rich, E.C., Woolfrey, B.F., Connelly, D.P. JAMA (1984) [Pubmed]
  13. TREK-1, a K+ channel involved in neuroprotection and general anesthesia. Heurteaux, C., Guy, N., Laigle, C., Blondeau, N., Duprat, F., Mazzuca, M., Lang-Lazdunski, L., Widmann, C., Zanzouri, M., Romey, G., Lazdunski, M. EMBO J. (2004) [Pubmed]
  14. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Stone, T.W. Trends Pharmacol. Sci. (2000) [Pubmed]
  15. Guidelines for carotid endarterectomy. A multidisciplinary consensus statement from the Ad Hoc Committee, American Heart Association. Moore, W.S., Barnett, H.J., Beebe, H.G., Bernstein, E.F., Brener, B.J., Brott, T., Caplan, L.R., Day, A., Goldstone, J., Hobson, R.W. Circulation (1995) [Pubmed]
  16. Manganese induces endoplasmic reticulum (ER) stress and activates multiple caspases in nigral dopaminergic neuronal cells, SN4741. Chun, H.S., Lee, H., Son, J.H. Neurosci. Lett. (2001) [Pubmed]
  17. Sodium valproate in the treatment of the intractable childhood epileptic. Keene, D.L., Metrakos, K., Watters, G.V., Sherwin, A. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1982) [Pubmed]
  18. Treatment of infantile spasms: an evidence-based approach. Mackay, M., Weiss, S., Snead, O.C. Int. Rev. Neurobiol. (2002) [Pubmed]
  19. Corticosteroid therapy and periodontal disease. Safkan, B., Knuuttila, M. Journal of clinical periodontology. (1984) [Pubmed]
  20. Dose-dependent increase in subjective symptoms among toluene-exposed workers. Ukai, H., Watanabe, T., Nakatsuka, H., Satoh, T., Liu, S.J., Qiao, X., Yin, H., Jin, C., Li, G.L., Ikeda, M. Environmental research. (1993) [Pubmed]
  21. Adult onset polymyositis/dermatomyositis: clinical and laboratory features and treatment response in 75 patients. Koh, E.T., Seow, A., Ong, B., Ratnagopal, P., Tjia, H., Chng, H.H. Ann. Rheum. Dis. (1993) [Pubmed]
  22. Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology. Cubells, J.F., Zabetian, C.P. Psychopharmacology (Berl.) (2004) [Pubmed]
  23. Interferon beta-1b reduces interferon gamma-induced antigen-presenting capacity of human glial and B cells. Jiang, H., Milo, R., Swoveland, P., Johnson, K.P., Panitch, H., Dhib-Jalbut, S. J. Neuroimmunol. (1995) [Pubmed]
  24. A geriatric special-care unit: experience in a university hospital. Saunders, R.H., Hickler, R.B., Hall, S.A., Hitzhusen, J.C., Ingraham, M.R., Li, L. Journal of the American Geriatrics Society. (1983) [Pubmed]
  25. Teaching pharmacology within a multidisciplinary organ system-based medical curriculum. Faingold, C.L., Dunaway, G.A. Naunyn Schmiedebergs Arch. Pharmacol. (2002) [Pubmed]
  26. Cardiac abnormalities and skeletal muscle weakness in carriers of Duchenne and Becker muscular dystrophies and controls. Grain, L., Cortina-Borja, M., Forfar, C., Hilton-Jones, D., Hopkin, J., Burch, M. Neuromuscul. Disord. (2001) [Pubmed]
  27. Cerebrospinal fluid enzymes in neurological diseases. Stensland, E., Sandberg, S., Berge, R., Aarli, J.A., Romslo, I. Acta neurologica Scandinavica. (1981) [Pubmed]
  28. The heterogeneity of temporal lobe epilepsy. Neurology, neuropsychology, and psychiatry. Paradiso, S., Hermann, B.P., Robinson, R.G. J. Nerv. Ment. Dis. (1995) [Pubmed]
  29. In vivo neurochemistry with emission tomography and magnetic resonance spectroscopy: clinical applications. Del Sole, A., Gambini, A., Falini, A., Lecchi, M., Lucignani, G. European radiology. (2002) [Pubmed]
  30. Royal Scoiety of Medicine, Section of Neurology; Meeting 31 October 1974. Presiden's Address. The nervous system's blood vessels from Galen to Röntgen and after. Bull, J.W. Proc. R. Soc. Med. (1975) [Pubmed]
  31. Mechanisms of neuronal adaptation to ethanol. Ethanol induces Hsc70 gene transcription in NG108-15 neuroblastoma x glioma cells. Miles, M.F., Diaz, J.E., DeGuzman, V.S. J. Biol. Chem. (1991) [Pubmed]
  32. Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia. Magerl, W., Fuchs, P.N., Meyer, R.A., Treede, R.D. Brain (2001) [Pubmed]
  33. Natural history of progressive ischemic stroke in a population treated with heparin. Slivka, A., Levy, D. Stroke (1990) [Pubmed]
  34. Implementation and application of a brain template for multiple volumes of interest. Hammers, A., Koepp, M.J., Free, S.L., Brett, M., Richardson, M.P., Labbé, C., Cunningham, V.J., Brooks, D.J., Duncan, J. Human brain mapping. (2002) [Pubmed]
  35. A follow-up survey of clinical practices for the use of heparin, warfarin, and aspirin. Alberts, M.J., Dawson, D.V., Massey, E.W. Neurology (1994) [Pubmed]
  36. Aberrant trajectory of thalamocortical axons associated with abnormal localization of neurocan immunoreactivity in the cerebral neocortex of reeler mutant mice. Li, H.P., Oohira, A., Ogawa, M., Kawamura, K., Kawano, H. Eur. J. Neurosci. (2005) [Pubmed]
  37. Tolcapone, a selective catechol-O-methyltransferase inhibitor for treatment of Parkinson's disease. Guay, D.R. Pharmacotherapy (1999) [Pubmed]
  38. Apolipoprotein E in neurology. Roses, A.D. Curr. Opin. Neurol. (1996) [Pubmed]
  39. Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury. Penkowa, M., Tio, L., Giralt, M., Quintana, A., Molinero, A., Atrian, S., Vasák, M., Hidalgo, J. J. Neurosci. Res. (2006) [Pubmed]
  40. Psychotherapeutic medication patterns for youths with attention-deficit/hyperactivity disorder. Zito, J.M., Safer, D.J., dosReis, S., Magder, L.S., Gardner, J.F., Zarin, D.A. Archives of pediatrics & adolescent medicine. (1999) [Pubmed]
  41. Reliability of the Part II board certification examination in psychiatry: examination stability. McDermott, J.F., Tanguay, P.E., Scheiber, S.C., Juul, D., Shore, J.H., Tucker, G.J., McCurdy, L., Terr, L.C. The American journal of psychiatry. (1993) [Pubmed]
  42. Nutritional status is a prognostic factor for survival in ALS patients. Desport, J.C., Preux, P.M., Truong, T.C., Vallat, J.M., Sautereau, D., Couratier, P. Neurology (1999) [Pubmed]
  43. A multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative Group. Richens, A., Davidson, D.L., Cartlidge, N.E., Easter, D.J. J. Neurol. Neurosurg. Psychiatr. (1994) [Pubmed]
  44. Gallbladder motility in children with Down syndrome. Taşdemir, H.A., Cetinkaya, M.C., Polat, C., Belet, U., Kalayci, A.G., Akbaş, S. J. Pediatr. Gastroenterol. Nutr. (2004) [Pubmed]
  45. Evaluation of Ames Seralyzer for the therapeutic drug monitoring of phenobarbital and phenytoin. Brettfeld, C., Gobrogge, R., Massoud, N., Munzenberger, P., Nigro, M., Sarnaik, A. Therapeutic drug monitoring. (1989) [Pubmed]
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