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MeSH Review


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Disease relevance of Pain


High impact information on Pain

  • Twenty-nine complications were burning pain at the IV site, and 36 were related to excessive total dose of phenytoin and resultant drug intoxication [5].
  • Topical application of capsaicin initiates a flare response and burning pain [6].
  • The TRPV1 agonists capsaicin, olvanil and arvanil all induced concentration-dependent increases in skin blood flow and burning pain when administered dermally [7].
  • Rheumatoid arthritis exacts a tremendous cost, not only in physical suffering but also in economic terms [8].
  • 5. Analysis of the interspike interval distribution and of the autocorrelation function derived from the chemically induced discharges of single units provided no evidence for an encoding of itch and burning pain in different discharge patterns of units responding to histamine and to mustard oil.(ABSTRACT TRUNCATED AT 250 WORDS)[9]

Chemical compound and disease context of Pain


Biological context of Pain


Anatomical context of Pain


Gene context of Pain

  • Six out of eight patients with thoracolumbar (T12 and L1) and lumbar (L3) fractures experienced intractable burning pain and/or rhizopathy [20].
  • CONCLUSION: The Quebec Task Force Classification demonstrated good predictive ability by discriminating between subjects with and those without distal radiating pain [21].


  1. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. LaMotte, R.H., Shain, C.N., Simone, D.A., Tsai, E.F. J. Neurophysiol. (1991) [Pubmed]
  2. Verapamil-induced secondary erythermalgia. Drenth, J.P., Michiels, J.J., Van Joost, T., Vuzevski, V.D. Br. J. Dermatol. (1992) [Pubmed]
  3. Third cervical nerve root and ganglion compression: clinical syndrome, surgical anatomy, and pathological findings. Poletti, C.E. Neurosurgery (1996) [Pubmed]
  4. Esophageal ulceration complicating doxycycline therapy. Al-Mofarreh, M.A., Al Mofleh, I.A. World J. Gastroenterol. (2003) [Pubmed]
  5. Complications of intravenous phenytoin for acute treatment of seizures. Recommendations for usage. Earnest, M.P., Marx, J.A., Drury, L.R. JAMA (1983) [Pubmed]
  6. Neurogenic flare responses following topical application of capsaicin in humans. Helme, R.D., McKernan, S. Ann. Neurol. (1985) [Pubmed]
  7. Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation. Movahed, P., Evilevitch, V., Andersson, T.L., Jönsson, B.A., Wollmer, P., Zygmunt, P.M., Högestätt, E.D. Br. J. Pharmacol. (2005) [Pubmed]
  8. The impact of pharmaco-economic considerations on the utilization of novel anti-rheumatic therapies. Lipsky, P.E., Kavanaugh, A. Rheumatology (Oxford, England) (1999) [Pubmed]
  9. Discharge patterns of human C-fibers induced by itching and burning stimuli. Handwerker, H.O., Forster, C., Kirchhoff, C. J. Neurophysiol. (1991) [Pubmed]
  10. A human oral capsaicin pain model to assess topical anesthetic-analgesic drugs. Ngom, P.I., Dubray, C., Woda, A., Dallel, R. Neurosci. Lett. (2001) [Pubmed]
  11. Spontaneous movements associated with rocuronium: is pain on injection the cause? Borgeat, A., Kwiatkowski, D. British journal of anaesthesia. (1997) [Pubmed]
  12. Treatment of primary erythromelalgia with cyproheptadine. Sakakibara, R., Fukutake, T., Kita, K., Hattori, T. J. Auton. Nerv. Syst. (1996) [Pubmed]
  13. Transient neurological symptoms after spinal anaesthesia with 4% mepivacaine and 0.5% bupivacaine. Hiller, A., Rosenberg, P.H. British journal of anaesthesia. (1997) [Pubmed]
  14. Effect of L-tryptophan and phenylalanine on burning pain threshold. Mitchell, M.J., Daines, G.E., Thomas, B.L. Physical therapy. (1987) [Pubmed]
  15. Differential effect on vasodilatation and pain after intradermal capsaicin in humans during decay of intravenous regional anesthesia with mepivacaine. Kalman, S., Linderfalk, C., Wårdell, K., Eintrei, C., Lisander, B. Regional anesthesia and pain medicine. (1998) [Pubmed]
  16. Primary erythromelalgia: the role of skin sympathetic nerve activity. Sugiyama, Y., Hakusui, S., Takahashi, A., Iwase, S., Mano, T. Jpn. J. Med. (1991) [Pubmed]
  17. Painful trigeminal neuropathy: clinical and pharmacological observations. Khurana, R.K., Mayer, R.F. Headache. (1997) [Pubmed]
  18. Substance P theory: a unique focus on the painful and painless phenomena of cluster headache. Sicuteri, F., Fanciullacci, M., Nicolodi, M., Geppetti, P., Fusco, B.M., Marabini, S., Alessandri, M., Campagnolo, V. Headache. (1990) [Pubmed]
  19. Brain-derived neurotrophic factor and vanilloid receptor subtype 1 immunoreactive sensory DRG neurons innervating the lumbar facet joints in rats. Ohtori, S., Takahashi, K., Chiba, T., Yamagata, M., Sameda, H., Moriya, H. Autonomic neuroscience : basic & clinical. (2001) [Pubmed]
  20. Burst fractures in the thoracic and lumbar spine. A clinico-neuropathologic analysis. Willen, J.A., Gaekwad, U.H., Kakulas, B.A. Spine. (1989) [Pubmed]
  21. Discriminative and predictive validity assessment of the quebec task force classification. Loisel, P., Vachon, B., Lemaire, J., Durand, M.J., Poitras, S., Stock, S., Tremblay, C. Spine. (2002) [Pubmed]
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