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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Morbillivirus


High impact information on Morbillivirus

  • In an in vivo replication/transcription system using a synthetic minigenome of RPV, we show that multimerization is essential for P protein function(s), and the multimerization domain is highly conserved between two morbilliviruses namely RPV and peste de petits ruminants virus [6].
  • Rational attenuation of a morbillivirus by modulating the activity of the RNA-dependent RNA polymerase [7].
  • To identify residues on the attachment protein hemagglutinin (H) essential for fusion support through either receptor, we devised a strategy based on analysis of morbillivirus H-protein sequences, iterative cycles of mutant protein production followed by receptor-based functional assays, and a novel MV H three-dimensional model [8].
  • Based on the crystal structure of the NDV F protein, we then predicted the locations of the Morbillivirus glycans: the glycan at position 36 is located in the F protein head, and those at positions 68 and 75 are located near the neck-stalk interface [4].
  • Immune responses to both the hemagglutinin (H) and the fusion (F) antigens of morbilliviruses play an important role in the prevention of infection, and only attenuated live vaccines have been shown to provide protective immunity against the group [9].

Chemical compound and disease context of Morbillivirus

  • Viral glycoprotein (H) and nucleoprotein (N) expression in adherent blood monocytes and monocyte-derived macrophages was compared with the infection in Vero cells, in which a productive infection typical of morbilliviruses is obtained [10].
  • Overall, the NP and in particular the F proteins of the morbilliviruses showed a high degree of epitopic homology; the P and M proteins showed a partial epitopic homology, with the greatest variation between the M proteins of CDV and MV; the H proteins showed a low degree of epitopic homology and then only between MV and RPV [11].
  • As to their origin, it appears that the most likely source of the European seal morbillivirus (PDV-1) is the North Atlantic and Artic seal populations [12].
  • As marine mammals are highly exposed to organochlorines, concentrations of PCBs, PCB MSFs, DDT, and DDE MSF were analyzed in blubber, lung, and uterus samples from harbor seal (Phoca vitulina) and striped dolphin (Stenella coeruleoalba) morbillivirus epizootic victims to investigate uterine and lung MSF accumulation [13].
  • A monoclonal antibody with genus-specific reactivity for morbilliviruses was applied in an indirect immunoperoxidase method performed on formalin-fixed, paraffin-embedded tissue sections [14].

Biological context of Morbillivirus


Anatomical context of Morbillivirus


Gene context of Morbillivirus

  • In these three morbilliviruses, all strains examined were shown to use SLAMs of their respective host species, and laboratory strains passaged on SLAM-negative cells were found to use, besides SLAM, alternative receptors, such as human CD46 for the Edmonston strain of MV [21].
  • As with other morbilliviruses, the phosphoprotein (P) gene of PDV was found to be located after the 5' end of the N gene and before the 3' end of the matrix protein gene [22].
  • When the DMV N gene coding region was compared with the corresponding sequences of other morbilliviruses a distant evolutionary relationship between these viruses and DMV was apparent [23].
  • This sequence, which is conserved in the N proteins of morbilliviruses, conforms well to the predicted algorithm for some of the most common BoLA CTL antigenic peptides [24].
  • The morbillivirus receptor SLAM (CD150) [21].

Analytical, diagnostic and therapeutic context of Morbillivirus

  • Recently an epizootic, reported to be due to a morbillivirus infection, affected the lion population of the Tanzanian Serengeti National Park. A morbillivirus phosphoprotein (P) gene fragment was amplified by PCR from tissue samples of several affected lions [25].


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  2. Morbillivirus downregulation of CD46. Galbraith, S.E., Tiwari, A., Baron, M.D., Lund, B.T., Barrett, T., Cosby, S.L. J. Virol. (1998) [Pubmed]
  3. Modulating the function of the measles virus RNA-dependent RNA polymerase by insertion of green fluorescent protein into the open reading frame. Duprex, W.P., Collins, F.M., Rima, B.K. J. Virol. (2002) [Pubmed]
  4. N-linked glycans with similar location in the fusion protein head modulate paramyxovirus fusion. von Messling, V., Cattaneo, R. J. Virol. (2003) [Pubmed]
  5. In vitro canine distemper virus infection of canine lymphoid cells: a prelude to oncolytic therapy for lymphoma. Suter, S.E., Chein, M.B., von Messling, V., Yip, B., Cattaneo, R., Vernau, W., Madewell, B.R., London, C.A. Clin. Cancer Res. (2005) [Pubmed]
  6. Phosphoprotein of the rinderpest virus forms a tetramer through a coiled coil region important for biological function. A structural insight. Rahaman, A., Srinivasan, N., Shamala, N., Shaila, M.S. J. Biol. Chem. (2004) [Pubmed]
  7. Rational attenuation of a morbillivirus by modulating the activity of the RNA-dependent RNA polymerase. Brown, D.D., Rima, B.K., Allen, I.V., Baron, M.D., Banyard, A.C., Barrett, T., Duprex, W.P. J. Virol. (2005) [Pubmed]
  8. Selectively receptor-blind measles viruses: Identification of residues necessary for SLAM- or CD46-induced fusion and their localization on a new hemagglutinin structural model. Vongpunsawad, S., Oezgun, N., Braun, W., Cattaneo, R. J. Virol. (2004) [Pubmed]
  9. Immunological responses of mice and cattle to baculovirus-expressed F and H proteins of rinderpest virus: lack of protection in the presence of neutralizing antibody. Bassiri, M., Ahmad, S., Giavedoni, L., Jones, L., Saliki, J.T., Mebus, C., Yilma, T. J. Virol. (1993) [Pubmed]
  10. Rinderpest virus infection of bovine peripheral blood monocytes. Rey Nores, J.E., Anderson, J., Butcher, R.N., Libeau, G., McCullough, K.C. J. Gen. Virol. (1995) [Pubmed]
  11. The antigenic relationship between measles, canine distemper and rinderpest viruses studied with monoclonal antibodies. Sheshberadaran, H., Norrby, E., McCullough, K.C., Carpenter, W.C., Orvell, C. J. Gen. Virol. (1986) [Pubmed]
  12. Morbilliviruses in aquatic mammals: report on round table discussion. Barrett, T., Blixenkrone-Møller, M., Di Guardo, G., Domingo, M., Duignan, P., Hall, A., Mamaev, L., Osterhaus, A.D. Vet. Microbiol. (1995) [Pubmed]
  13. Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims. Troisi, G.M., Haraguchi, K., Kaydoo, D.S., Nyman, M., Aguilar, A., Borrell, A., Siebert, U., Mason, C.F. J. Toxicol. Environ. Health Part A (2001) [Pubmed]
  14. Viral antigen distribution in organs of cattle experimentally infected with rinderpest virus. Wohlsein, P., Trautwein, G., Harder, T.C., Liess, B., Barrett, T. Vet. Pathol. (1993) [Pubmed]
  15. Identification of immunodominant neutralizing epitopes on the hemagglutinin protein of rinderpest virus. Sugiyama, M., Ito, N., Minamoto, N., Tanaka, S. J. Virol. (2002) [Pubmed]
  16. Sequence analysis of the Hendra virus nucleoprotein gene: comparison with other members of the subfamily Paramyxovirinae. Yu, M., Hansson, E., Shiell, B., Michalski, W., Eaton, B.T., Wang, L.F. J. Gen. Virol. (1998) [Pubmed]
  17. The phosphoprotein gene of a dolphin morbillivirus isolate exhibits genomic variation at the editing site. Bolt, G., Alexandersen, S., Blixenkrone-Møller, M. J. Gen. Virol. (1995) [Pubmed]
  18. Comparison of messenger RNAs induced in cells infected with each member of the morbillivirus group. Barrett, T., Underwood, B. Virology (1985) [Pubmed]
  19. Dolphin and porpoise morbilliviruses are genetically distinct from phocine distemper virus. Barrett, T., Visser, I.K., Mamaev, L., Goatley, L., van Bressem, M.F., Osterhaust, A.D. Virology (1993) [Pubmed]
  20. Activated mouse T-cells synthesize MHC class II, process, and present morbillivirus nucleocapsid protein to primed T-cells. Lal, G., Shaila, M.S., Nayak, R. Cell. Immunol. (2005) [Pubmed]
  21. The morbillivirus receptor SLAM (CD150). Tatsuo, H., Yanagi, Y. Microbiol. Immunol. (2002) [Pubmed]
  22. Sequence analysis of the genes encoding the nucleocapsid protein and phosphoprotein (P) of phocid distemper virus, and editing of the P gene transcript. Blixenkrone-Möller, M., Sharma, B., Varsanyi, T.M., Hu, A., Norrby, E., Kövamees, J. J. Gen. Virol. (1992) [Pubmed]
  23. Comparative analysis of the gene encoding the nucleocapsid protein of dolphin morbillivirus reveals its distant evolutionary relationship to measles virus and ruminant morbilliviruses. Blixenkrone-Møller, M., Bolt, G., Gottschalck, E., Kenter, M. J. Gen. Virol. (1994) [Pubmed]
  24. Identification of a cytotoxic T-cell epitope on the recombinant nucleocapsid proteins of Rinderpest and Peste des petits ruminants viruses presented as assembled nucleocapsids. Mitra-Kaushik, S., Nayak, R., Shaila, M.S. Virology (2001) [Pubmed]
  25. Phylogenetic evidence of canine distemper virus in Serengeti's lions. Harder, T.C., Kenter, M., Appel, M.J., Roelke-Parker, M.E., Barrett, T., Osterhaus, A.D. Vaccine (1995) [Pubmed]
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