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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

H  -  type II transmembrane glycoprotein;...

Measles virus

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Biological context of H


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  • Faint reactivity was obtained against MV-matrix (M) or hemagglutinin protein (H) in the minority of samples (40 and 20%, respectively) [24].
  • Cell fusion induced by cotransfection of cells with MV F and H (hemagglutinin) genes was significantly reduced after replacement of Cys 506 or Cys 519 with serine in the MV F gene [25].
  • The hemadsorption activity of the cells could be enhanced (30 to 70%) by treatment with actinomycin D or enucleation with cytochalasin B; these treatments, however, were unsuccessful in inducing detectable levels of measles hemagglutinin [26].
  • The resulting two distinct RFLP patterns identified the hemagglutinin types with regard to the presence or absence of the potential new glycosylation site [27].
  • Three monoclonal antibodies (MAbs) against the fusion (F) and one MAb against the hemagglutinin (H) protein of MV were labelled with biotin and used in biotin-streptavidin EIA system [28].

Regulatory relationships of H


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Analytical, diagnostic and therapeutic context of H


  1. A chimeric human-bovine parainfluenza virus type 3 expressing measles virus hemagglutinin is attenuated for replication but is still immunogenic in rhesus monkeys. Skiadopoulos, M.H., Surman, S.R., Riggs, J.M., Collins, P.L., Murphy, B.R. J. Virol. (2001) [Pubmed]
  2. Rinderpest virus phosphoprotein gene is a major determinant of species-specific pathogenicity. Yoneda, M., Miura, R., Barrett, T., Tsukiyama-Kohara, K., Kai, C. J. Virol. (2004) [Pubmed]
  3. Susceptibility to measles virus-induced encephalitis in mice correlates with impaired antigen presentation to cytotoxic T lymphocytes. Niewiesk, S., Brinckmann, U., Bankamp, B., Sirak, S., Liebert, U.G., ter Meulen, V. J. Virol. (1993) [Pubmed]
  4. Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis. Finke, D., Brinckmann, U.G., ter Meulen, V., Liebert, U.G. J. Virol. (1995) [Pubmed]
  5. Antigen mimicry involving measles virus hemagglutinin and human respiratory syncytial virus nucleoprotein. Norrby, E., Sheshberadaran, H., Rafner, B. J. Virol. (1986) [Pubmed]
  6. Polar appearance and nonligand induced spreading of measles virus hemagglutinin at the surface of chronically infected cells. Ehrnst, A., Sundqvist, K.G. Cell (1975) [Pubmed]
  7. Disruption of Akt kinase activation is important for immunosuppression induced by measles virus. Avota, E., Avots, A., Niewiesk, S., Kane, L.P., Bommhardt, U., ter Meulen, V., Schneider-Schaulies, S. Nat. Med. (2001) [Pubmed]
  8. Successful DNA immunization against measles: neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles. Polack, F.P., Lee, S.H., Permar, S., Manyara, E., Nousari, H.G., Jeng, Y., Mustafa, F., Valsamakis, A., Adams, R.J., Robinson, H.L., Griffin, D.E. Nat. Med. (2000) [Pubmed]
  9. T-cell independent IgM and enduring protective IgG antibodies induced by chimeric measles viruses. Fehr, T., Naim, H.Y., Bachmann, M.F., Ochsenbein, A.F., Spielhofer, P., Bucher, E., Hengartner, H., Billeter, M.A., Zinkernagel, R.M. Nat. Med. (1998) [Pubmed]
  10. Monoclonal antibodies against five structural components of measles virus. II. Characterization of five cell lines persistently infected with measles virus. Sheshberadaran, H., Norrby, E., Rammohan, K.W. Arch. Virol. (1985) [Pubmed]
  11. Characterization of a region of the measles virus hemagglutinin sufficient for its dimerization. Plemper, R.K., Hammond, A.L., Cattaneo, R. J. Virol. (2000) [Pubmed]
  12. Effects of protease inhibitors on replication of various myxoviruses. Hosoya, M., Matsuyama, S., Baba, M., Suzuki, H., Shigeta, S. Antimicrob. Agents Chemother. (1992) [Pubmed]
  13. Visualization of defective measles virus particles in cerebrospinal fluid in subacute sclerosing panencephalitis. Andersson, J., Ehrnst, A., Larsson, P.H., Hedlund, K.O., Norrby, E., Nybom, R., Forsgren, M., Olding-Stenquist, E., Persson, B. J. Infect. Dis. (1987) [Pubmed]
  14. Measles virus hemagglutinin. Removal of the initiator methionine in the mature protein, and evidence for further processing to produce a 'ragged' end. Varsanyi, T.M., Lundquist, G., Norrby, E., Jörnvall, H. FEBS Lett. (1986) [Pubmed]
  15. Amino acid substitutions at position 481 differently affect the ability of the measles virus hemagglutinin to induce cell fusion in monkey and marmoset cells co-expressing the fusion protein. Xie, M., Tanaka, K., Ono, N., Minagawa, H., Yanagi, Y. Arch. Virol. (1999) [Pubmed]
  16. Antigenic modulation induced by monoclonal antibodies: antibodies to measles virus hemagglutinin alters expression of other viral polypeptides in infected cells. Fujinami, R.S., Norrby, E., Oldstone, M.B. J. Immunol. (1984) [Pubmed]
  17. Development of antibody to measles virus polypeptides during complicated and uncomplicated measles virus infections. Graves, M., Griffin, D.E., Johnson, R.T., Hirsch, R.L., de Soriano, I.L., Roedenbeck, S., Vaisberg, A. J. Virol. (1984) [Pubmed]
  18. Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases. Cattaneo, R., Schmid, A., Spielhofer, P., Kaelin, K., Baczko, K., ter Meulen, V., Pardowitz, J., Flanagan, S., Rima, B.K., Udem, S.A. Virology (1989) [Pubmed]
  19. Genetic analysis of Asian measles virus strains--new endemic genotype in Nepal. Truong, A.T., Mulders, M.N., Gautam, D.C., Ammerlaan, W., de Swart, R.L., King, C.C., Osterhaus, A.D., Muller, C.P. Virus Res. (2001) [Pubmed]
  20. Efficient major histocompatibility complex class II-restricted presentation of measles virus relies on hemagglutinin-mediated targeting to its cellular receptor human CD46 expressed by murine B cells. Gerlier, D., Trescol-Biémont, M.C., Varior-Krishnan, G., Naniche, D., Fugier-Vivier, I., Rabourdin-Combe, C. J. Exp. Med. (1994) [Pubmed]
  21. Transmembrane communication in cells chronically infected with measles virus. Tyrrell, D.L., Ehrnst, A. J. Cell Biol. (1979) [Pubmed]
  22. Neutralizing human Fab fragments against measles virus recovered by phage display. de Carvalho Nicacio, C., Williamson, R.A., Parren, P.W., Lundkvist, A., Burton, D.R., Björling, E. J. Virol. (2002) [Pubmed]
  23. Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion. Ehrengruber, M.U., Ehler, E., Billeter, M.A., Naim, H.Y. J. Virol. (2002) [Pubmed]
  24. Antibody reactivity to individual structural proteins of measles virus in the CSF of SSPE and MS patients. Pohl-Koppe, A., Kaiser, R., Meulen, V.T., Liebert, U.G. Clinical and diagnostic virology. (1995) [Pubmed]
  25. Measles virus fusion protein is palmitoylated on transmembrane-intracytoplasmic cysteine residues which participate in cell fusion. Caballero, M., Carabaña, J., Ortego, J., Fernández-Muñoz, R., Celma, M.L. J. Virol. (1998) [Pubmed]
  26. Characterization of an in vitro persistent-state measles virus infection: establishment and virological characterization of the BGM/MV cell line. Menna, J.H., Collins, A.R., Flanagan, T.D. Infect. Immun. (1975) [Pubmed]
  27. Molecular identification of two distinct hemagglutinin types of measles virus by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Saito, H., Nakagomi, O., Morita, M. Mol. Cell. Probes (1995) [Pubmed]
  28. Measurement of polypeptide- and antigenic site-specific antibodies to measles virus using a competitive enzyme immunoassay. Mäkelä, M.J., Norrby, E., Salmi, A. J. Virol. Methods (1987) [Pubmed]
  29. Induction of measles virus-specific human cytotoxic T cells by purified measles virus nucleocapsid and hemagglutinin polypeptides. Jacobson, S., Rose, J.W., Flerlage, M.L., McFarlin, D.E., McFarland, H.F. Viral Immunol. (1987) [Pubmed]
  30. Characteristics of fresh isolates of wild measles virus. Sakaguchi, M., Yoshikawa, Y., Yamanouchi, K., Takeda, K., Sato, T. Jpn. J. Exp. Med. (1986) [Pubmed]
  31. Evaluation of monoclonal antibody-based capture enzyme immunoassays for detection of specific antibodies to measles virus. Erdman, D.D., Anderson, L.J., Adams, D.R., Stewart, J.A., Markowitz, L.E., Bellini, W.J. J. Clin. Microbiol. (1991) [Pubmed]
  32. Monoclonal antibodies against five structural components of measles virus. I. Characterization of antigenic determinants on nine strains of measles virus. Sheshberadaran, H., Chen, S.N., Norrby, E. Virology (1983) [Pubmed]
  33. Measles virus persistence in an immortalized murine macrophage cell line. Goldman, M.B., Buckthal, D.J., Picciotto, S., O'Bryan, T.A., Goldman, J.N. Virology (1995) [Pubmed]
  34. Detection of measles virus genome directly from clinical samples by reverse transcriptase-polymerase chain reaction and genetic variability. Nakayama, T., Mori, T., Yamaguchi, S., Sonoda, S., Asamura, S., Yamashita, R., Takeuchi, Y., Urano, T. Virus Res. (1995) [Pubmed]
  35. Structural polypeptides of canine distemper virus. Orvell, C. Arch. Virol. (1980) [Pubmed]
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