Disease relevance of Food, Fortified

• BACKGROUND: Recommendations by the UK Department of Health suggest that protection from neural tube defects (NTD) can be achieved through intakes of an extra 400 microgram daily of folate/folic acid as natural food, foods fortified with folic acid, or supplements [1].
• CONCLUSIONS: Significant associations were found for those with large adenomas or cancer (but not small adenomas), with age, and with foods enriched for vitamin A, vitamin E, and beta-carotene [2].

High impact information on Food, Fortified

• The amounts of retinol in fortified foods and vitamin supplements may need to be reassessed [3].
• Based on projections from the positive folate balance in the group that received 100 micrograms daily, this dose taken continually, as it will be in fortified food, will also produce an important decrease in NTD [4].
• Neither basal nor CCK-stimulated amylase release from isolated pancreatic lobules was altered after tryptophan enriched food [5].
• CONCLUSIONS: Iron bioavailability from a high-phytate, cereal-based complementary food fortified with either NaFeEDTA or ferrous sulfate plus ascorbic acid was not significantly different [6].
• BACKGROUND: Phytic acid is a strong inhibitor of iron absorption from fortified foods [6].

Biological context of Food, Fortified

• Bioavailability of folic acid in fortified food [7].
• The time related changes in serum folate and tHcy were affected only by intake of folate fortified foods (p < 0.0005) and not by any other measured variables including age, sex, or MTHFR genotype [8].
• DHA enriched foods increased HDL-C by 6.0% (95% CI 2.5%, 9.6%) but had no effect on total or low-density cholesterol or blood pressure [9].
• The current public health message encouraging women to select folic acid fortified foods and take folic acid supplements, needs to continue [10].

Associations of Food, Fortified with chemical compounds

• Red-cell folate concentrations increased significantly over the 3 months in the groups taking folic acid supplements (group I) or food fortified with folic acid (group II) only (p<0.01 for both groups) [1].
• We compared iron intake and iron nutritional status of two groups of healthy term infants who received meat-containing baby foods fortified with ferrous sulphate (2 mg Fe/100 g) [11].
• Fortified foods contribute one half of recommended vitamin A intake in poor urban Guatemalan toddlers [12].
• It has been demonstrated that functional foods enriched with plant sterols and stanols are effective in various population groups, and in combination with cholesterol-lowering diets or drugs [13].
• The breakfast cereal category was responsible for nearly all the intake of nutrients from fortified foods, except vitamin C for which juice-type beverages made as great or a greater contribution [14].

Gene context of Food, Fortified

• Because the prevalence of combined B12 insufficiency and supraphysiological concentrations of serum folate may have increased with folic acid food fortification, consideration should be given to confirming this finding, and possibly, to the addition of B12 to folate fortified foods [15].
• They developed an LC-mass spectrometry (LC/MS) method for the determination of vitamin B5 in a wide range of fortified food products [16].
• The implementation of these findings will require among other things, a range of n-3 fat enriched foods, as well as physician awareness of the possibilities for dietary n-3 fat increases to be used as adjunctive therapy in RA [17].
• The targeted population is the general population (not simply high-risk subjects) and the antioxidant agents tested are being administered at a level which is not pharmacologic and which may be attained by dietary intake of natural sources of these micronutrients and/or enriched foods [18].
• It is now important to determine whether Lfcin is generated in the intestinal tract of formula-fed and breast-fed infants, and geriatric patients consuming foods enriched with lactoferrin [19].

Analytical, diagnostic and therapeutic context of Food, Fortified

• Determination of vitamin A derivatives in fortified foods and commercial vitamin supplements by high-performance liquid chromatography [20].
• To investigate the influence of food enriched with acetic acid on the clinical, biochemical, electrolyte, blood gas, haematological and urinary variables in the dog, a cross-over study was carried out with periods of approximately 2 weeks involving six healthy, adult dogs [21].

References